1 to 7 of 7 literature results

• PPAR-delta senses and orchestrates clearance of apoptotic cells to promote tolerance.

  Macrophages rapidly engulf apoptotic cells to limit the release of noxious cellular contents and to restrict autoimmune responses against self antigen…

  Authors: Lata Mukundan, Justin I Odegaard, Christine R Morel, Jose E Heredia, Julia W Mwangi, Roberto R Ricardo-Gonzalez, Y P Sharon Goh, Alex Red Eagle, Shannon E Dunn, Jennifer U H Awakuni,…

  Source: Nature medicine. 2009 Nov

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• Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance.

  Obesity and insulin resistance, the cardinal features of metabolic syndrome, are closely associated with a state of low-grade inflammation. In adipose…

  Authors: Justin I Odegaard, Roberto R Ricardo-Gonzalez, Matthew H Goforth, Christine R Morel, Vidya Subramanian, Lata Mukundan, Alex Red Eagle, Divya Vats, Frank Brombacher, Anthony W Ferrante,…

  Source: Nature. 2007 Jun 28

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• CD40-mediated activation of vascular smooth muscle cell chemokine production through a Src-initiated, MAPK-dependent pathway.

  The interaction between CD40 ligand (CD154) expressed on activated T cells and its receptor, CD40, has been shown to play a role in the onset and main…

  Authors: Lata Mukundan, Denise M Milhorn, Bharati Matta, Jill Suttles

  Source: Cellular signalling. 2004 Mar

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• Generation of a multimeric form of CD40L with potent immunostimulatory activity using streptavidin as a chaperon.

  Effective aggregation of cell surface immune receptors with their ligands is critical in promoting humoral and cellular immune responses. Simulation o…

  Authors: Mehmet O Kilinc, Lata Mukundan, Esma S Yolcu, Narendra P Singh, Jill Suttles, Haval Shirwan

  Source: Experimental and molecular pathology. 2006 Jun

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• Alternative M2 activation of Kupffer cells by PPARdelta ameliorates obesity-induced insulin resistance.

  Macrophage infiltration and activation in metabolic tissues underlie obesity-induced insulin resistance and type 2 diabetes. While inflammatory activa…

  Authors: Justin I Odegaard, Roberto R Ricardo-Gonzalez, Alex Red Eagle, Divya Vats, Christine R Morel, Matthew H Goforth, Vidya Subramanian, Lata Mukundan, Anthony W Ferrante, Ajay Chawla

  Source: Cell metabolism. 2008 Jun

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• TNF receptor-associated factor 6 is an essential mediator of CD40-activated proinflammatory pathways in monocytes and macrophages.

  The interaction between CD40 and its ligand, CD154, has been shown to play a role in the onset and maintenance of inflammatory disease. Contributing t…

  Authors: Lata Mukundan, Gail A Bishop, Kimberly Z Head, Lihua Zhang, Larry M Wahl, Jill Suttles

  Source: Journal of immunology (Baltimore, Md. : 1950). 2005 Jan 15

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• Oxidative metabolism and PGC-1beta attenuate macrophage-mediated inflammation.

  Complex interplay between T helper (Th) cells and macrophages contributes to the formation and progression of atherosclerotic plaques. While Th1 cytok…

  Authors: Divya Vats, Lata Mukundan, Justin I Odegaard, Lina Zhang, Kristi L Smith, Christine R Morel, Roger A Wagner, David R Greaves, Peter J Murray, Ajay Chawla

  Source: Cell metabolism. 2006 Jul

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