1 to 10 of 275 literature results

• Joint analysis is more efficient than replication-based analysis for two-stage genome-wide association studies.

  Genome-wide association is a promising approach to identify common genetic variants that predispose to human disease. Because of the high cost of geno…

  Authors: Andrew D Skol, Laura J Scott, Gonçalo R Abecasis, Michael Boehnke

  Source: Nature genetics. 2006 Feb

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• Prothrombin complex concentrate (Beriplex P/N).

  Beriplex P/N, a prothrombin complex concentrate derived from pooled human plasma, contains the vitamin K-dependent coagulation factors II, VII, IX and…

  Authors: Lesley J Scott

  Source: Drugs. 2009 Oct 1

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• Iloperidone: in schizophrenia.

  Iloperidone is an atypical antipsychotic that is approved for the treatment of adult patients with schizophrenia. In several large (n > 570 per trial)…

  Authors: Lesley J Scott

  Source: CNS drugs. 2009 Oct 1

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• Allelic expression imbalance at high-density lipoprotein cholesterol locus MMAB-MVK.

  Genome-wide association studies (GWAS) have identified numerous loci associated with various complex traits for which the underlying susceptibility ge…

  Authors: Marie P Fogarty, Rui Xiao, Ludmila Prokunina-Olsson, Laura J Scott, Karen L Mohlke

  Source: Human molecular genetics. 2010 May 15

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• Besifloxacin ophthalmic suspension 0.6%.

  Besifloxacin is a novel fluoroquinolone that, like other fluoroquinolones, acts by inhibiting the essential bacterial enzymes DNA gyrase and topoisome…

  Authors: Natalie J Carter, Lesley J Scott

  Source: Drugs. 2010

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• Raltegravir: in treatment-naive patients with HIV-1 infection.

  Raltegravir, a first-in-class, oral HIV type-1 (HIV-1) integrase inhibitor, blocks the covalent integration of HIV-1 complementary DNA into the host g…

  Authors: Jamie D Croxtall, Lesley J Scott

  Source: Drugs. 2010 Mar 26

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• Dapoxetine: in premature ejaculation.

  Dapoxetine, a selective serotonin reuptake inhibitor, is the first oral pharmacological agent indicated for the treatment of men aged 18-64 years with…

  Authors: Sheridan M Hoy, Lesley J Scott

  Source: Drugs. 2010 Jul 30

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• Estradiol valerate/dienogest: in oral contraception.

  Estradiol valerate/dienogest is an oral contraceptive for women that combines the natural estrogen estradiol with the 19-nortestosterone derivative di…

  Authors: Sheridan M Hoy, Lesley J Scott

  Source: Drugs. 2009 Aug 20

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• Palonosetron: in the prevention of nausea and vomiting.

  Palonosetron is a second-generation serotonin 5-HT3 receptor antagonist, with a distinct pharmacological profile that differs from first-generation 5-…

  Authors: Lily P H Yang, Lesley J Scott

  Source: Drugs. 2009 Nov 12

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• Gefitinib: a review of its use in the treatment of locally advanced/metastatic non-small cell lung cancer.

  Gefitinib (Iressa) is an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor that offers treatment for patients with locally advanced or…

  Authors: Mark Sanford, Lesley J Scott

  Source: Drugs. 2009 Nov 12

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