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Viral vectors for production of recombinant proteins in plants.
Global demand for recombinant proteins has steadily accelerated for the last 20 years. These recombinant proteins have a wide range of important appli…
Authors: Chiara Lico, Qiang Chen, Luca Santi
Source: Journal of cellular physiology. 2008 Aug
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Administration of chondroitinase ABC rostral or caudal to a spinal cord injury site promotes anatomical but not functional plasticity.
Growth-inhibitory chondroitin sulfate proteoglycans (CSPG) are a primary target for therapeutic strategies after spinal cord injury because of their c…
Authors: Veronica J Tom, Rachel Kadakia, Lauren Santi, John D Houlé
Source: Journal of neurotrauma. 2009 Dec
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Plant derived veterinary vaccines.
Infectious diseases remain one of the main causes of death and economic losses in animals despite the fact that prophylactic vaccination has been extr…
Authors: L Santi
Source: Veterinary research communications. 2009 Sep
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Plant-derived recombinant F1, V, and F1-V fusion antigens of Yersinia pestis activate human cells of the innate and adaptive immune system.
Plague is still endemic in different regions of the world. Current vaccines raise concern for their side effects and limited protection, highlighting …
Authors: G Del Prete, L Santi, V Andrianaivoarimanana, A Amedei, O Domarle, M M D' Elios, C J Arntzen, L Rahalison, H S Mason
Source: International journal of immunopathology and pharmacology. 2009 Jan-Mar
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Differential immunoproteomics enables identification of Metarhizium anisopliae proteins related to Rhipicephalus microplus infection.
Differential immunoproteomics was applied to identify proteins secreted by Metarhizium anisopliae induced by the Rhipicephalus microplus cuticle. In a…
Authors: Lucélia Santi, Walter Orlando Beys da Silva, Antônio Frederico Michel Pinto, Augusto Schrank, Marilene Henning Vainstein
Source: Research in microbiology. 2009 Dec
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An efficient plant viral expression system generating orally immunogenic Norwalk virus-like particles.
Virus-like particles (VLPs) derived from enteric pathogens like Norwalk virus (NV) are well suited to study oral immunization. We previously described…
Authors: Luca Santi, Lance Batchelor, Zhong Huang, Brooke Hjelm, Jacquelyn Kilbourne, Charles J Arntzen, Qiang Chen, Hugh S Mason
Source: Vaccine. 2008 Mar 28
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The aspartate aminotransferase family in conifers: biochemical analysis of a prokaryotic-type enzyme from maritime pine.
Plant aspartate aminotransferase (AAT, EC 2.6.1.1) plays a key role in primary nitrogen assimilation, the transfer of reducing equivalents and the int…
Authors: Fernando de la Torre, María Fernanda Suárez, Laura de Santis, Francisco M Cánovas
Source: Tree physiology. 2007 Sep
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Rapid, high-level production of hepatitis B core antigen in plant leaf and its immunogenicity in mice.
Hepatitis B core antigen (HBc or HBcAg) self-assembles into capsid particles and is extremely immunogenic. HBc has been extensively studied for its pr…
Authors: Zhong Huang, Luca Santi, Kate LePore, Jacquelyn Kilbourne, Charles J Arntzen, Hugh S Mason
Source: Vaccine. 2006 Mar 24
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A study of 4- and 7-day triple therapy with rabeprazole, high-dose levofloxacin and tinidazole rescue treatment for Helicobacter pylori eradication.
BACKGROUND: Helicobacter pylori treatment failure is becoming an emergent problem in clinical practice. Shorter treatment duration should improve comp…
Authors: E G Giannini, C Bilardi, P Dulbecco, M Mamone, M L Santi, R Testa, C Mansi, V Savarino
Source: Alimentary pharmacology & therapeutics. 2006 Jan 15
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Genetics of barley hooded suppression.
The molecular basis of the barley dominant Hooded (K) mutant is a duplication of 305 bp in intron IV of the homeobox gene Bkn3. A chemical mutagenesis…
Authors: Cristina Roig, Carlo Pozzi, Luca Santi, Judith Müller, Yamei Wang, Maria Rosaria Stile, Laura Rossini, Michele Stanca, Francesco Salamini
Source: Genetics. 2004 May
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