1 to 4 of 4 literature results

• Inhibition of AMP-activated protein kinase protects pancreatic beta-cells from cytokine-mediated apoptosis and CD8+ T-cell-induced cytotoxicity.

  OBJECTIVE: Apoptotic destruction of insulin-producing pancreatic beta-cells is involved in the etiology of both type 1 and type 2 diabetes. AMP-activa…

  Authors: Audrey Riboulet-Chavey, Frédérique Diraison, L Khai Siew, F Susan Wong, Guy A Rutter

  Source: Diabetes. 2008 Feb

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• CD8+ T-cells and their interaction with other cells in damage to islet beta-cells.

  The autoimmune attack on pancreatic beta-cells is orchestrated by a variety of cells that produce cytokines and other toxic mediators. CD8(+) T-cells …

  Authors: F Susan Wong, L Khai Siew, Li Wen

  Source: Biochemical Society transactions. 2008 Jun

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• Premorbid effects of APOE on synaptic proteins in human temporal neocortex.

  APOE affects the risk of Alzheimer's disease (AD) and course of several other neurologic diseases. Experimental studies suggest that APOE influences s…

  Authors: Seth Love, L Khai Siew, David Dawbarn, Gordon K Wilcock, Yoav Ben-Shlomo, Shelley J Allen

  Source: Neurobiology of aging. 2006 Jun

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• Developing a novel model system to target insulin-reactive CD8 T cells.

  CD8 T cells play an important role in autoimmune diabetes development, and therefore removing these cells may protect against disease. To test this, w…

  Authors: Gwen S Scott, Sigal Fishman, Alon Margalit, L Khai Siew, Stephen Chapman, Li Wen, Gideon Gross, F Susan Wong

  Source: Annals of the New York Academy of Sciences. 2008 Dec

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