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• Human renal cancer cells express a novel membrane-bound interleukin-15 that induces, in response to the soluble interleukin-15 receptor alpha chain, epithelial-to-mesenchymal transition.

  Although interleukin-15 (IL-15) is a powerful immunomodulatory factor that has been proposed for cancer immunotherapy, its intratumoral expression may…

  Authors: Krystel Khawam, Julien Giron-Michel, Yanhong Gu, Aurélie Perier, Massimo Giuliani, Anne Caignard, Aurore Devocelle, Silvano Ferrini, Marina Fabbi, Bernard Charpentier,…

  Source: Cancer research. 2009 Feb 15

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• Membrane-bound interleukin (IL)-15 on renal tumor cells rescues natural killer cells from IL-2 starvation-induced apoptosis.

  Renal cell carcinoma primary tumors and lung metastases are infiltrated by activated natural killer (NK) cells. Interleukin (IL)-15, a major cytokine …

  Authors: Sebastian Wittnebel, Sylvie Da Rocha, Julien Giron-Michel, Abdelali Jalil, Paule Opolon, Bernard Escudier, Pierre Validire, Krystel Khawam, Salem Chouaib, Bruno Azzarone,…

  Source: Cancer research. 2007 Jun 15

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