1 to 10 of 11 literature results

• Myosin II and mechanotransduction: a balancing act.

  Adherent cells respond to mechanical properties of the surrounding extracellular matrix. Mechanical forces, sensed at specialized cell-matrix adhesion…

  Authors: Kristopher Clark, Michiel Langeslag, Carl G Figdor, Frank N van Leeuwen

  Source: Trends in cell biology. 2007 Apr

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• Mice deficient in the Rac activator Tiam1 are resistant to Ras-induced skin tumours.

  Proteins of the Rho family control signalling pathways that regulate the actin cytoskeleton and gene transcription. In vitro studies have implicated R…

  Authors: Angeliki Malliri, Rob A van der Kammen, Kristopher Clark, Maarten van der Valk, Frits Michiels, John G Collard

  Source: Nature. 2002 Jun 20

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• TRPM7 regulates myosin IIA filament stability and protein localization by heavy chain phosphorylation.

  Deregulation of myosin II-based contractility contributes to the pathogenesis of human diseases, such as cancer, which underscores the necessity for t…

  Authors: Kristopher Clark, Jeroen Middelbeek, Edwin Lasonder, Natalya G Dulyaninova, Nick A Morrice, Alexey G Ryazanov, Anne R Bresnick, Carl G Figdor, Frank N van Leeuwen

  Source: Journal of molecular biology. 2008 May 9

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• Interplay between TRP channels and the cytoskeleton in health and disease.

  Transient receptor potential (TRP) channels are a family of cation channels that play a key role in ion homeostasis and cell volume regulation. In add…

  Authors: Kristopher Clark, Jeroen Middelbeek, Frank N van Leeuwen

  Source: European journal of cell biology. 2008 Sep

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• The alpha-kinases TRPM6 and TRPM7, but not eEF-2 kinase, phosphorylate the assembly domain of myosin IIA, IIB and IIC.

  TRPM6 and TRPM7 encode channel-kinases. While these channels share electrophysiological properties and cellular functions, TRPM6 and TRPM7 are non-red…

  Authors: Kristopher Clark, Jeroen Middelbeek, Maxim V Dorovkov, Carl G Figdor, Alexey G Ryazanov, Edwin Lasonder, Frank N van Leeuwen

  Source: FEBS letters. 2008 Sep 3

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• Eosinophil degranulation in the allergic lung of mice primarily occurs in the airway lumen.

  Eosinophil degranulation is thought to play a pivotal role in the pathogenesis of allergic disorders. Although mouse models of allergic disorders have…

  Authors: Kristopher Clark, Ljubov Simson, Nicole Newcombe, Aulikki M L Koskinen, Joerg Mattes, Nancy A Lee, James J Lee, Lindsay A Dent, Klaus I Matthaei, Paul S Foster

  Source: Journal of leukocyte biology. 2004 Jun

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• The alpha-kinase family: an exceptional branch on the protein kinase tree.

  The alpha-kinase family represents a class of atypical protein kinases that display little sequence similarity to conventional protein kinases. Early …

  Authors: Jeroen Middelbeek, Kristopher Clark, Hanka Venselaar, Martijn A Huynen, Frank N van Leeuwen

  Source: Cellular and molecular life sciences : CMLS. 2010 Mar

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• Use of the pharmacological inhibitor BX795 to study the regulation and physiological roles of TBK1 and IkappaB kinase epsilon: a distinct upstream kinase mediates Ser-172 phosphorylation and activation.

  TANK-binding kinase 1 (TBK1) and IkappaB kinase epsilon (IKKepsilon) regulate the production of Type 1 interferons during bacterial and viral infectio…

  Authors: Kristopher Clark, Lorna Plater, Mark Peggie, Philip Cohen

  Source: The Journal of biological chemistry. 2009 May 22

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• Massive autophosphorylation of the Ser/Thr-rich domain controls protein kinase activity of TRPM6 and TRPM7.

  TRPM6 and TRPM7 are bifunctional proteins expressing a TRP channel fused to an atypical alpha-kinase domain. While the gating properties of TRPM6 and …

  Authors: Kristopher Clark, Jeroen Middelbeek, Nick A Morrice, Carl G Figdor, Edwin Lasonder, Frank N van Leeuwen

  Source: PloS one. 2008

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• Activation of TRPM7 channels by phospholipase C-coupled receptor agonists.

  TRPM7 is a ubiquitously expressed nonspecific cation channel that has been implicated in cellular Mg(2+) homeostasis. We have recently shown that mode…

  Authors: Michiel Langeslag, Kristopher Clark, Wouter H Moolenaar, Frank N van Leeuwen, Kees Jalink

  Source: The Journal of biological chemistry. 2007 Jan 5

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