1 to 10 of 27 literature results

• Can cells and biomaterials in therapeutic medicine be shielded from innate immune recognition?

  Biomaterials (e.g. polymers, metals, or ceramics), cell and cell cluster (e.g. pancreatic islets) transplantation are beginning to offer novel treatme…

  Authors: Bo Nilsson, Olle Korsgren, John D Lambris, Kristina Nilsson Ekdahl

  Source: Trends in immunology. 2010 Jan

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• Complement and coagulation: strangers or partners in crime?

  The convergence between complement and the clotting system extends far beyond the chemical nature of the complement and coagulation components, both o…

  Authors: Maciej M Markiewski, Bo Nilsson, Kristina Nilsson Ekdahl, Tom Eirik Mollnes, John D Lambris

  Source: Trends in immunology. 2007 Apr

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• Structures of complement component C3 provide insights into the function and evolution of immunity.

  The mammalian complement system is a phylogenetically ancient cascade system that has a major role in innate and adaptive immunity. Activation of comp…

  Authors: Bert J C Janssen, Eric G Huizinga, Hans C A Raaijmakers, Anja Roos, Mohamed R Daha, Kristina Nilsson-Ekdahl, Bo Nilsson, Piet Gros

  Source: Nature. 2005 Sep 22

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• Activated human platelets induce factor XIIa-mediated contact activation.

  Earlier studies have shown that isolated platelets in buffer systems can promote activation of FXII or amplify contact activation, in the presence of …

  Authors: Jennie Bäck, Javier Sanchez, Graciela Elgue, Kristina Nilsson Ekdahl, Bo Nilsson

  Source: Biochemical and biophysical research communications. 2010 Jan 1

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• Distinctive regulation of contact activation by antithrombin and C1-inhibitor on activated platelets and material surfaces.

  Activated human plate lets trigger FXII-mediated contact activation, which leads to the generation of FXIIa-antithrombin (AT) and FXIa-AT complexes. T…

  Authors: Jennie Bäck, Markus Huber Lang, Graciela Elgue, Miriam Kalbitz, Javier Sanchez, Kristina Nilsson Ekdahl, Bo Nilsson

  Source: Biomaterials. 2009 Dec

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• The role of complement in biomaterial-induced inflammation.

  Biomaterials are regularly used in various types of artificial tissues and organs, such as oxygenators, plasmapheresis equipment, hemodialysers, cathe…

  Authors: Bo Nilsson, Kristina Nilsson Ekdahl, Tom Eirik Mollnes, John D Lambris

  Source: Molecular immunology. 2007 Jan

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• Tissue factor produced by the endocrine cells of the islets of Langerhans is associated with a negative outcome of clinical islet transplantation.

  There are strong indications that only a small fraction of grafts successfully engraft in clinical islet transplantation. One explanation may be the i…

  Authors: Helena Johansson, Agneta Lukinius, Lisa Moberg, Torbjörn Lundgren, Christian Berne, Aksel Foss, Marie Felldin, Ragnar Källen, Kaija Salmela, Annika Tibell,…

  Source: Diabetes. 2005 Jun

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• Identification of complement C3 as an autoantigen in inflammatory bowel disease.

  OBJECTIVE: Autoantibodies against goblet cells in the gastrointestinal mucosa have been described in patients with inflammatory bowel disease (IBD) bu…

  Authors: Brita Ardesjö Lundgren, Fredrik Rorsman, Guida M Portela-Gomes, Lars Grimelius, Kristina Nilsson Ekdahl, Bo Nilsson, Olov Ekwall

  Source: European journal of gastroenterology & hepatology. 2010 Apr

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• Prothrombotic effects of prostasomes isolated from prostatic cancer cell lines and seminal plasma.

  Thromboembolism is well recognized as a major complication of cancer. Many tumor cells overexpress tissue factor (TF), which activates blood coagulati…

  Authors: Adil A Babiker, Kristina Nilsson Ekdahl, Bo Nilsson, Gunnar Ronquist

  Source: Seminars in thrombosis and hemostasis. 2007 Feb

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• Inhibition of thrombin abrogates the instant blood-mediated inflammatory reaction triggered by isolated human islets: possible application of the thrombin inhibitor melagatran in clinical islet transplantation.

  A thrombotic/inflammatory reaction is elicited when isolated islets of Langerhans come in contact with ABO-compatible blood. The detrimental effects o…

  Authors: Lisa Ozmen, Kristina Nilsson Ekdahl, Graciela Elgue, Rolf Larsson, Olle Korsgren, Bo Nilsson

  Source: Diabetes. 2002 Jun

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