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Lenalidomide and pomalidomide have both been evaluated clinically for their properties as anticancer agents, with lenalidomide being available commerc…
Authors: Laure Escoubet-Lozach, I-Lin Lin, Kristen Jensen-Pergakes, Helen A Brady, Anita K Gandhi, Peter H Schafer, George W Muller, Peter J Worland, Kyle W H Chan, Dominique Verhelle
Source: Cancer research. 2009 Sep 15
View Full TextClinical studies involving patients with myelodysplastic syndromes or multiple myeloma have shown the efficacy of lenalidomide by reducing and often e…
Authors: Dominique Verhelle, Laura G Corral, Kevin Wong, Jessica H Mueller, Laure Moutouh-de Parseval, Kristen Jensen-Pergakes, Peter H Schafer, Roger Chen, Emilia Glezer, Gregory D Ferguson,…
Source: Cancer research. 2007 Jan 15
View Full TextEngineered phage-based vectors are an attractive alternative strategy for gene delivery because they possess no natural mammalian cell tropism and can…
Authors: Michael A Burg, Kristen Jensen-Pergakes, Ana Maria Gonzalez, Prenn Ravey, Andrew Baird, David Larocca
Source: Cancer research. 2002 Feb 15
View Full TextCOX2 (prostaglandin G/H synthase, PTGS2) is a well-validated target in the fields of both oncology and inflammation. Despite their significant toxicit…
Authors: Gregory D Ferguson, Kristen Jensen-Pergakes, Candice Wilkey, Urvi Jhaveri, Normand Richard, Dominique Verhelle, Laure Moutouh De Parseval, Laura G Corral, Weilin Xie, Christopher L Morris,…
Source: Journal of clinical immunology. 2007 Mar
View Full TextSickle-cell disease (SCD) and beta thalassemia constitute worldwide public health problems. New therapies, including hydroxyurea, have attempted to au…
Authors: Laure A Moutouh-de Parseval, Dominique Verhelle, Emilia Glezer, Kristen Jensen-Pergakes, Gregory D Ferguson, Laura G Corral, Christopher L Morris, George Muller, Helen Brady, Kyle Chan
Source: The Journal of clinical investigation. 2008 Jan
View Free Full Textp27, an important cell cycle regulator, blocks the G(1)/S transition in cells by binding and inhibiting Cdk2/cyclin A and Cdk2/cyclin E complexes (Cdk…
Authors: Shuichan Xu, Mahan Abbasian, Palka Patel, Kristen Jensen-Pergakes, Christian R Lombardo, Brian E Cathers, Weilin Xie, Frank Mercurio, Michele Pagano, David Giegel,…
Source: The Journal of biological chemistry. 2007 May 25
View Full TextWe adapted filamentous phage vectors for targeted gene delivery to mammalian cells by inserting a mammalian reporter gene expression cassette (GFP) in…
Authors: David Larocca, Michael A Burg, Kristen Jensen-Pergakes, Edward Prenn Ravey, Ana Maria Gonzalez, Andrew Baird
Source: Current pharmaceutical biotechnology. 2002 Mar
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