1 to 7 of 7 literature results

• Pomalidomide and lenalidomide induce p21 WAF-1 expression in both lymphoma and multiple myeloma through a LSD1-mediated epigenetic mechanism.

  Lenalidomide and pomalidomide have both been evaluated clinically for their properties as anticancer agents, with lenalidomide being available commerc…

  Authors: Laure Escoubet-Lozach, I-Lin Lin, Kristen Jensen-Pergakes, Helen A Brady, Anita K Gandhi, Peter H Schafer, George W Muller, Peter J Worland, Kyle W H Chan, Dominique Verhelle

  Source: Cancer research. 2009 Sep 15

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• Lenalidomide and CC-4047 inhibit the proliferation of malignant B cells while expanding normal CD34+ progenitor cells.

  Clinical studies involving patients with myelodysplastic syndromes or multiple myeloma have shown the efficacy of lenalidomide by reducing and often e…

  Authors: Dominique Verhelle, Laura G Corral, Kevin Wong, Jessica H Mueller, Laure Moutouh-de Parseval, Kristen Jensen-Pergakes, Peter H Schafer, Roger Chen, Emilia Glezer, Gregory D Ferguson,…

  Source: Cancer research. 2007 Jan 15

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• Enhanced phagemid particle gene transfer in camptothecin-treated carcinoma cells.

  Engineered phage-based vectors are an attractive alternative strategy for gene delivery because they possess no natural mammalian cell tropism and can…

  Authors: Michael A Burg, Kristen Jensen-Pergakes, Ana Maria Gonzalez, Prenn Ravey, Andrew Baird, David Larocca

  Source: Cancer research. 2002 Feb 15

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• Immunomodulatory drug CC-4047 is a cell-type and stimulus-selective transcriptional inhibitor of cyclooxygenase 2.

  COX2 (prostaglandin G/H synthase, PTGS2) is a well-validated target in the fields of both oncology and inflammation. Despite their significant toxicit…

  Authors: Gregory D Ferguson, Kristen Jensen-Pergakes, Candice Wilkey, Urvi Jhaveri, Normand Richard, Dominique Verhelle, Laure Moutouh De Parseval, Laura G Corral, Weilin Xie, Christopher L Morris,…

  Source: Journal of clinical immunology. 2007 Mar

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• Pomalidomide and lenalidomide regulate erythropoiesis and fetal hemoglobin production in human CD34+ cells.

  Sickle-cell disease (SCD) and beta thalassemia constitute worldwide public health problems. New therapies, including hydroxyurea, have attempted to au…

  Authors: Laure A Moutouh-de Parseval, Dominique Verhelle, Emilia Glezer, Kristen Jensen-Pergakes, Gregory D Ferguson, Laura G Corral, Christopher L Morris, George Muller, Helen Brady, Kyle Chan

  Source: The Journal of clinical investigation. 2008 Jan

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• Substrate recognition and ubiquitination of SCFSkp2/Cks1 ubiquitin-protein isopeptide ligase.

  p27, an important cell cycle regulator, blocks the G(1)/S transition in cells by binding and inhibiting Cdk2/cyclin A and Cdk2/cyclin E complexes (Cdk…

  Authors: Shuichan Xu, Mahan Abbasian, Palka Patel, Kristen Jensen-Pergakes, Christian R Lombardo, Brian E Cathers, Weilin Xie, Frank Mercurio, Michele Pagano, David Giegel,…

  Source: The Journal of biological chemistry. 2007 May 25

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• Evolving phage vectors for cell targeted gene delivery.

  We adapted filamentous phage vectors for targeted gene delivery to mammalian cells by inserting a mammalian reporter gene expression cassette (GFP) in…

  Authors: David Larocca, Michael A Burg, Kristen Jensen-Pergakes, Edward Prenn Ravey, Ana Maria Gonzalez, Andrew Baird

  Source: Current pharmaceutical biotechnology. 2002 Mar

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