1 to 10 of 26 literature results

• Pharmacological properties of YM-254890, a specific G(alpha)q/11 inhibitor, on thrombosis and neointima formation in mice.

  The pharmacological properties of YM-254890, a specific G(alpha)q/11 inhibitor, on acute thrombosis and chronic neointima formation after vascular inj…

  Authors: Tomihisa Kawasaki, Masatoshi Taniguchi, Yumiko Moritani, Toshio Uemura, Takeshi Shigenaga, Hajime Takamatsu, Kazumi Hayashi, Jun Takasaki, Tetsu Saito, Koji Nagai

  Source: Thrombosis and haemostasis. 2005 Jul

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• YM753, a novel histone deacetylase inhibitor, exhibits antitumor activity with selective, sustained accumulation of acetylated histones in tumors in the WiDr xenograft model.

  Histone deacetylase (HDAC) inhibitors have been shown to have antitumor activity in vitro and in vivo. Various studies related to their antitumor acti…

  Authors: Nobuaki Shindoh, Masamichi Mori, Yoh Terada, Kazuo Oda, Nobuaki Amino, Aya Kita, Masatoshi Taniguchi, Kin-Ya Sohda, Koji Nagai, Yoshihiro Sowa,…

  Source: International journal of oncology. 2008 Mar

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• Antithrombotic and thrombolytic efficacy of YM-254890, a G q/11 inhibitor, in a rat model of arterial thrombosis.

  We examined the antithrombotic and thrombolytic effects of the G(q/11) inhibitor YM-254890 in an electrically-induced carotid artery thrombosis model …

  Authors: Tomihisa Kawasaki, Masatoshi Taniguchi, Yumiko Moritani, Kazumi Hayashi, Tetsu Saito, Jun Takasaki, Koji Nagai, Osamu Inagaki, Hisataka Shikama

  Source: Thrombosis and haemostasis. 2003 Sep

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• A refractory case of MPO-ANCA-associated vasculitis presented with gastrointestinal ulcer, rapidly progressive glomerular nephritis and pulmonary multiple nodules

  The patient was a 57-year-old male, who developed bloody stool around May 2006. He was examined by another physician in the department of gastroentero…

  Authors: Daisuke Wakaura, Masako Yoneda, Takuya Kotani, Yutarou Egashira, Koji Nagai, Takeshi Shoda, Maki Kagitani, Tohru Takeuchi, Shigeki Makino, Toshiaki Hanafusa

  Source: Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology. 2010

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• Three new cyclostellettamines, which inhibit histone deacetylase, from a marine sponge of the genus Xestospongia.

  Three new cyclostellettamines, cyclostellettamine G (1), dehydrocyclostellettamines D (2), and E (3), were isolated together with the known cyclostell…

  Authors: Naoya Oku, Koji Nagai, Nobuaki Shindoh, Yoh Terada, Rob W M van Soest, Shigeki Matsunaga, Nobuhiro Fusetani

  Source: Bioorganic & medicinal chemistry letters. 2004 May 17

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• Naphthalecin, a novel antibiotic produced by the anaerobic bacterium, Sporotalea colonica sp. nov.

  A novel antibiotic naphthalecin was purified and isolated from the cells of an anaerobic bacterium isolated from a soil sample. This antibiotic contai…

  Authors: Masami Ezaki, Hideyuki Muramatsu, Shigehiro Takase, Michizane Hashimoto, Koji Nagai

  Source: The Journal of antibiotics. 2008 Apr

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• YM-254890 analogues, novel cyclic depsipeptides with Galpha(q/11) inhibitory activity from Chromobacterium sp. QS3666.

  The structure elucidation and biological activity of novel YM-254890 (1) analogues and semi-synthetic derivatives are described. Three natural analogu…

  Authors: Masatoshi Taniguchi, Ken-Ichi Suzumura, Koji Nagai, Tomihisa Kawasaki, Jun Takasaki, Mitsuhiro Sekiguchi, Yumiko Moritani, Tetsu Saito, Kazumi Hayashi, Shigeo Fujita,…

  Source: Bioorganic & medicinal chemistry. 2004 Jun 15

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• Structure of thioviridamide, a novel apoptosis inducer from Streptomyces olivoviridis.

  A novel apoptosis inducer, thioviridamide, was isolated from an actinomycete identified as Streptomyces olivoviridis. The molecular formula of thiovir…

  Authors: Yoichi Hayakawa, Kahori Sasaki, Koji Nagai, Kazuo Shin-ya, Kazuo Furihata

  Source: The Journal of antibiotics. 2006 Jan

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• Successful treatment of thrombotic thrombocytopenic purpura with repeated plasma exchange in a patient with microscopic polyangitis.

  Thrombotic thrombocytopenic purpura (TTP) is in rare cases associated with antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis, and o…

  Authors: Koji Nagai, Takuya Kotani, Tohru Takeuchi, Takeshi Shoda, Ayu Hata-Kobayashi, Daisuke Wakura, Maki Kagitani, Shigeki Makino, Toshiaki Hanafusa

  Source: Modern rheumatology / the Japan Rheumatism Association. 2008

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• Burkholone, a new cytotoxic antibiotic against IGF-I dependent cells from Burkholderia sp.

  In the course of our screening program for new inhibitors of IGF-I signaling, we isolated a new cytotoxic antibiotic, burkholone, from the culture bro…

  Authors: Toshiya Mori, Tomoki Yamashita, Kazuo Furihata, Koji Nagai, Ken-Ichi Suzuki, Yoichi Hayakawa, Kazuo Shin-Ya

  Source: The Journal of antibiotics. 2007 Nov

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