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SUMOylation of Krüppel-like transcription factor 5 acts as a molecular switch in transcriptional programs of lipid metabolism involving PPAR-delta.
Obesity and metabolic syndrome are increasingly recognized as major risk factors for cardiovascular disease. Herein we show that Krüppel-like transcri…
Authors: Yumiko Oishi, Ichiro Manabe, Kazuyuki Tobe, Mitsuru Ohsugi, Tetsuya Kubota, Katsuhito Fujiu, Koji Maemura, Naoto Kubota, Takashi Kadowaki, Ryozo Nagai
Source: Nature medicine. 2008 Jun
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DeltaEF1 mediates TGF-beta signaling in vascular smooth muscle cell differentiation.
Alteration in the differentiated state of smooth muscle cells (SMCs) is known to be integral to vascular development and the pathogenesis of vascular …
Authors: Go Nishimura, Ichiro Manabe, Kensuke Tsushima, Katsuhito Fujiu, Yumiko Oishi, Yasushi Imai, Koji Maemura, Makoto Miyagishi, Yujiro Higashi, Hisato Kondoh,…
Source: Developmental cell. 2006 Jul
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Statins protect human aortic smooth muscle cells from inorganic phosphate-induced calcification by restoring Gas6-Axl survival pathway.
Vascular calcification is clinically important in the development of cardiovascular disease. It is reported that hydroxy-3-methylglutaryl coenzyme A (…
Authors: Bo-Kyung Son, Koichi Kozaki, Katsuya Iijima, Masato Eto, Taro Kojima, Hidetaka Ota, Yuka Senda, Koji Maemura, Toru Nakano, Masahiro Akishita,…
Source: Circulation research. 2006 Apr 28
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Adiponectin antagonizes stimulatory effect of tumor necrosis factor-alpha on vascular smooth muscle cell calcification: regulation of growth arrest-specific gene 6-mediated survival pathway by adenosine 5'-monophosphate-activated protein kinase.
Adiponectin exhibits diverse protective effects against atherogenesis and antagonizes many effects of TNFalpha. Here, we investigated the effect of ad…
Authors: Bo-Kyung Son, Masahiro Akishita, Katsuya Iijima, Koichi Kozaki, Koji Maemura, Masato Eto, Yasuyoshi Ouchi
Source: Endocrinology. 2008 Apr
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Images in cardiovascular medicine. Lung perfusion blood volume computed tomographic images of pulmonary embolism: before and after thrombolysis.
Authors: Eijun Sueyoshi, Shin Tsutsui, Ichiro Sakamoto, Masataka Uetani, Koji Maemura
Source: Circulation. 2009 Jun 30
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Synthetic retinoid Am80 suppresses smooth muscle phenotypic modulation and in-stent neointima formation by inhibiting KLF5.
Modulation of smooth muscle cell (SMC) phenotype plays a central role in neointima formation. We recently demonstrated that Am80, a synthetic retinoic…
Authors: Katsuhito Fujiu, Ichiro Manabe, Atsushi Ishihara, Yumiko Oishi, Hiroshi Iwata, Go Nishimura, Takayuki Shindo, Koji Maemura, Hiroyuki Kagechika, Koichi Shudo,…
Source: Circulation research. 2005 Nov 25
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Krüppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling.
We recently isolated a Krüppel-like zinc-finger transcription factor 5 (KLF5; also known as BTEB2 and IKLF), which is markedly induced in activated va…
Authors: Takayuki Shindo, Ichiro Manabe, Yasushi Fukushima, Kazuyuki Tobe, Kenichi Aizawa, Saku Miyamoto, Keiko Kawai-Kowase, Nobuo Moriyama, Yasushi Imai, Hayato Kawakami,…
Source: Nature medicine. 2002 Aug
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Endothelial PAS domain protein 1 gene promotes angiogenesis through the transactivation of both vascular endothelial growth factor and its receptor, Flt-1.
Endothelial PAS domain protein 1 (EPAS1) is a basic-helix-loop-helix/PAS domain transcription factor that is expressed preferentially in vascular endo…
Authors: Norihiko Takeda, Koji Maemura, Yasushi Imai, Tomohiro Harada, Daiji Kawanami, Takefumi Nojiri, Ichiro Manabe, Ryozo Nagai
Source: Circulation research. 2004 Jul 23
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Regulation of smooth muscle cell differentiation by AT-rich interaction domain transcription factors Mrf2alpha and Mrf2beta.
Despite the importance of vascular smooth muscle cells in the regulation of blood vessel function, the molecular mechanisms governing their developmen…
Authors: Masafumi Watanabe, Matthew D Layne, Chung-Ming Hsieh, Koji Maemura, Susan Gray, Mu-En Lee, Mukesh K Jain
Source: Circulation research. 2002 Sep 6
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Characterization of the mouse aortic carboxypeptidase-like protein promoter reveals activity in differentiated and dedifferentiated vascular smooth muscle cells.
The dedifferentiation and proliferation of vascular smooth muscle cells (VSMCs) contribute to the formation of vascular lesions. In this study, the re…
Authors: Matthew D Layne, Shaw-Fang Yet, Koji Maemura, Chung-Ming Hsieh, Xiaoli Liu, Bonna Ith, Mu-En Lee, Mark A Perrella
Source: Circulation research. 2002 Apr 5
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