1 to 5 of 5 literature results

• Impaired microRNA processing enhances cellular transformation and tumorigenesis.

  MicroRNAs (miRNAs) are a new class of small noncoding RNAs that post-transcriptionally regulate the expression of target mRNA transcripts. Many of the…

  Authors: Madhu S Kumar, Jun Lu, Kim L Mercer, Todd R Golub, Tyler Jacks

  Source: Nature genetics. 2007 May

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• Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects.

  Activating mutations in the ras oncogene are not considered sufficient to induce abnormal cellular proliferation in the absence of cooperating oncogen…

  Authors: David A Tuveson, Alice T Shaw, Nicholas A Willis, Daniel P Silver, Erica L Jackson, Sandy Chang, Kim L Mercer, Rebecca Grochow, Hanno Hock, Denise Crowley,…

  Source: Cancer cell. 2004 Apr

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• Modulation of tumor induction and progression of oncogenic K-ras-positive tumors in the presence of TGF- b1 haploinsufficiency.

  Oncogenic K-ras is one of the most common genetic alterations in human lung adenocarcinomas. In addition, inactivation of clusters of tumor suppressor…

  Authors: Jyotsna Pandey, Sarah M Umphress, Yang Kang, Jerry Angdisen, Alena Naumova, Kim L Mercer, Tyler Jacks, Sonia B Jakowlew

  Source: Carcinogenesis. 2007 Dec

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• p53 controls radiation-induced gastrointestinal syndrome in mice independent of apoptosis.

  Acute exposure to ionizing radiation can cause lethal damage to the gastrointestinal (GI) tract, a condition called the GI syndrome. Whether the targe…

  Authors: David G Kirsch, Philip M Santiago, Emmanuelle di Tomaso, Julie M Sullivan, Wu-Shiun Hou, Talya Dayton, Laura B Jeffords, Pooja Sodha, Kim L Mercer, Rhianna Cohen,…

  Source: Science (New York, N.Y.). 2010 Jan 29

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• ARF mutation accelerates pituitary tumor development in Rb+/- mice.

  Mice heterozygous for the retinoblastoma (Rb) tumor suppressor gene develop pituitary and thyroid tumors with high penetrance. We demonstrate here tha…

  Authors: Kenneth Y Tsai, David MacPherson, Douglas A Rubinson, Alexander Yu Nikitin, Roderick Bronson, Kim L Mercer, Denise Crowley, Tyler Jacks

  Source: Proceedings of the National Academy of Sciences of the United States of America. 2002 Dec 24

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