1 to 10 of 22 literature results

• Bmi1 regulates mitochondrial function and the DNA damage response pathway.

  Mice deficient in the Polycomb repressor Bmi1 develop numerous abnormalities including a severe defect in stem cell self-renewal, alterations in thymo…

  Authors: Jie Liu, Liu Cao, Jichun Chen, Shiwei Song, In Hye Lee, Celia Quijano, Hongjun Liu, Keyvan Keyvanfar, Haoqian Chen, Long-Yue Cao,…

  Source: Nature. 2009 May 21

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• T-bet, a Th1 transcription factor, is up-regulated in T cells from patients with aplastic anemia.

  In aplastic anemia, immune destruction of hematopoietic cells results in bone marrow failure. Type 1 cytokines, especially IFN-gamma, have been implic…

  Authors: Elena E Solomou, Keyvan Keyvanfar, Neal S Young

  Source: Blood. 2006 May 15

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• Rabbit ATG but not horse ATG promotes expansion of functional CD4+CD25highFOXP3+ regulatory T cells in vitro.

  Regulatory T cells (Treg) play important roles in suppressing immune responses and maintaining tolerance. Rabbit antithymocyte globulin (rATG) and hor…

  Authors: Xingmin Feng, Sachiko Kajigaya, Elena E Solomou, Keyvan Keyvanfar, Xiuli Xu, Nalini Raghavachari, Peter J Munson, Thomas M Herndon, Jichun Chen, Neal S Young

  Source: Blood. 2008 Apr 1

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• Primitive quiescent CD34+ cells in chronic myeloid leukemia are targeted by in vitro expanded natural killer cells, which are functionally enhanced by bortezomib.

  Primitive quiescent CD34(+) chronic myeloid leukemia (CML) cells are more biologically resistant to tyrosine kinase inhibitors than their cycling coun…

  Authors: Agnes S M Yong, Keyvan Keyvanfar, Nancy Hensel, Rhoda Eniafe, Bipin N Savani, Maria Berg, Andreas Lundqvist, Sharon Adams, Elaine M Sloand, John M Goldman,…

  Source: Blood. 2009 Jan 22

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• Ex vivo characterization of polyclonal memory CD8+ T-cell responses to PRAME-specific peptides in patients with acute lymphoblastic leukemia and acute and chronic myeloid leukemia.

  Preferentially expressed antigen of melanoma (PRAME) is aberrantly expressed in hematologic malignancies and may be a useful target for immunotherapy …

  Authors: Katayoun Rezvani, Agnes S M Yong, Abdul Tawab, Behnam Jafarpour, Rhoda Eniafe, Stephan Mielke, Bipin N Savani, Keyvan Keyvanfar, Yixin Li, Roger Kurlander,…

  Source: Blood. 2009 Mar 5

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• Graft-versus-leukemia effects associated with detectable Wilms tumor-1 specific T lymphocytes after allogeneic stem-cell transplantation for acute lymphoblastic leukemia.

  To determine whether the leukemia-associated Wilms tumor antigen (WT1) contributes to a graft-versus-leukemia (GVL) effect after allogeneic stem-cell …

  Authors: Katayoun Rezvani, Agnes S M Yong, Bipin N Savani, Stephan Mielke, Keyvan Keyvanfar, Emma Gostick, David A Price, Daniel C Douek, A John Barrett

  Source: Blood. 2007 Sep 15

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• Deficient CD4+ CD25+ FOXP3+ T regulatory cells in acquired aplastic anemia.

  Regulatory T cells are believed to control the development and progression of autoimmunity by suppressing autoreactive T cells. Decreased numbers of C…

  Authors: Elena E Solomou, Katayoun Rezvani, Stephan Mielke, Daniela Malide, Keyvan Keyvanfar, Valeria Visconte, Sachiko Kajigaya, A John Barrett, Neal S Young

  Source: Blood. 2007 Sep 1

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• Ex vivo-generated CD36+ erythroid progenitors are highly permissive to human parvovirus B19 replication.

  The pathogenic parvovirus B19 (B19V) has an extreme tropism for human erythroid progenitor cells. In vitro, only a few erythroid leukemic cell lines (…

  Authors: Susan Wong, Ning Zhi, Claudia Filippone, Keyvan Keyvanfar, Sachiko Kajigaya, Kevin E Brown, Neal S Young

  Source: Journal of virology. 2008 Mar

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• High donor FOXP3-positive regulatory T-cell (Treg) content is associated with a low risk of GVHD following HLA-matched allogeneic SCT.

  Regulatory T cells (T(reg)s) that constitutively express FOXP3 are instrumental to the maintenance of tolerance and may suppress graft-versus-host dis…

  Authors: Katayoun Rezvani, Stephan Mielke, Mojgan Ahmadzadeh, Yasemin Kilical, Bipin N Savani, Josette Zeilah, Keyvan Keyvanfar, Aldemar Montero, Nancy Hensel, Roger Kurlander,…

  Source: Blood. 2006 Aug 15

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• Transfer of glycosylphosphatidylinositol-anchored proteins to deficient cells after erythrocyte transfusion in paroxysmal nocturnal hemoglobinuria.

  In paroxysmal nocturnal hemoglobinuria (PNH), an acquired mutation of the PIGA gene results in the absence of glycosylphosphatidylinositol (GPI)-ancho…

  Authors: Elaine M Sloand, Lori Mainwaring, Keyvan Keyvanfar, Jichun Chen, Jaroslaw Maciejewski, Harvey G Klein, Neal S Young

  Source: Blood. 2004 Dec 1

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