1 to 4 of 4 literature results

• The aryl propionic acid R-flurbiprofen selectively induces p75NTR-dependent decreased survival of prostate tumor cells.

  Epidemiologic studies show that patients chronically consuming nonsteroidal anti-inflammatory drugs (NSAID) for arthritis exhibit a reduced incidence …

  Authors: Emily J Quann, Fatima Khwaja, Kenton H Zavitz, Daniel Djakiew

  Source: Cancer research. 2007 Apr 1

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• Efficacy and safety of tarenflurbil in mild to moderate Alzheimer's disease: a randomised phase II trial.

  BACKGROUND: The amyloid-beta peptide Abeta(42) has been implicated in the pathogenesis of Alzheimer's disease (AD). We aimed to test the effects of ta…

  Authors: Gordon K Wilcock, Sandra E Black, Suzanne B Hendrix, Kenton H Zavitz, Edward A Swabb, Mark A Laughlin, Tarenflurbil Phase II Study investigators

  Source: Lancet neurology. 2008 Jun

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• Safety, tolerability, pharmacokinetics, and Abeta levels after short-term administration of R-flurbiprofen in healthy elderly individuals.

  To evaluate the safety and tolerability and pharmacokinetic properties of R-flurbiprofen (Tarenflurbil) in normal elderly individuals and to determine…

  Authors: Douglas R Galasko, Neil Graff-Radford, Susanne May, Suzanne Hendrix, Barbara A Cottrell, Sarah A Sagi, Gary Mather, Mark Laughlin, Kenton H Zavitz, Edward Swabb,…

  Source: Alzheimer disease and associated disorders. 2007 Oct-Dec

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• NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo.

  Epidemiologic studies demonstrate that long-term use of NSAIDs is associated with a reduced risk for the development of Alzheimer disease (AD). In thi…

  Authors: Jason L Eriksen, Sarah A Sagi, Tawnya E Smith, Sascha Weggen, Pritam Das, D C McLendon, Victor V Ozols, Kevin W Jessing, Kenton H Zavitz, Edward H Koo,…

  Source: The Journal of clinical investigation. 2003 Aug

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