1 to 8 of 8 literature results

• STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane.

  As the sole Ca2+ entry mechanism in a variety of non-excitable cells, store-operated calcium (SOC) influx is important in Ca2+ signalling and many oth…

  Authors: Shenyuan L Zhang, Ying Yu, Jack Roos, J Ashot Kozak, Thomas J Deerinck, Mark H Ellisman, Kenneth A Stauderman, Michael D Cahalan

  Source: Nature. 2005 Oct 6

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• Molecular basis of the CRAC channel.

  Ca(2+) release-activated Ca(2+) (CRAC) channels, located in the plasma membrane, are opened upon release of Ca(2+) from intracellular stores, permitti…

  Authors: Michael D Cahalan, Shenyuan L Zhang, Andriy V Yeromin, Kari Ohlsen, Jack Roos, Kenneth A Stauderman

  Source: Cell calcium. 2007 Aug

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• Orai1 and STIM1 move to the immunological synapse and are up-regulated during T cell activation.

  For efficient development of an immune response, T lymphocytes require long-lasting calcium influx through calcium release-activated calcium (CRAC) ch…

  Authors: Maria I Lioudyno, J Ashot Kozak, Aubin Penna, Olga Safrina, Shenyuan L Zhang, Debasish Sen, Jack Roos, Kenneth A Stauderman, Michael D Cahalan

  Source: Proceedings of the National Academy of Sciences of the United States of America. 2008 Feb 12

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• Genome-wide RNAi screen of Ca(2+) influx identifies genes that regulate Ca(2+) release-activated Ca(2+) channel activity.

  Recent studies by our group and others demonstrated a required and conserved role of Stim in store-operated Ca(2+) influx and Ca(2+) release-activated…

  Authors: Shenyuan L Zhang, Andriy V Yeromin, Xiang H-F Zhang, Ying Yu, Olga Safrina, Aubin Penna, Jack Roos, Kenneth A Stauderman, Michael D Cahalan

  Source: Proceedings of the National Academy of Sciences of the United States of America. 2006 Jun 13

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• A store-operated calcium channel in Drosophila S2 cells.

  Using whole-cell recording in Drosophila S2 cells, we characterized a Ca(2+)-selective current that is activated by depletion of intracellular Ca2+ st…

  Authors: Andriy V Yeromin, Jack Roos, Kenneth A Stauderman, Michael D Cahalan

  Source: The Journal of general physiology. 2004 Feb

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• STIM1, an essential and conserved component of store-operated Ca2+ channel function.

  Store-operated Ca2+ (SOC) channels regulate many cellular processes, but the underlying molecular components are not well defined. Using an RNA interf…

  Authors: Jack Roos, Paul J DiGregorio, Andriy V Yeromin, Kari Ohlsen, Maria Lioudyno, Shenyuan Zhang, Olga Safrina, J Ashot Kozak, Steven L Wagner, Michael D Cahalan,…

  Source: The Journal of cell biology. 2005 May 9

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• Modal gating of human CaV2.1 (P/Q-type) calcium channels: I. The slow and the fast gating modes and their modulation by beta subunits.

  The single channel gating properties of human CaV2.1 (P/Q-type) calcium channels and their modulation by the auxiliary beta1b, beta2e, beta3a, and bet…

  Authors: Siro Luvisetto, Tommaso Fellin, Michele Spagnolo, Bruno Hivert, Paul F Brust, Michael M Harpold, Kenneth A Stauderman, Mark E Williams, Daniela Pietrobon

  Source: The Journal of general physiology. 2004 Nov

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• Recent advances in the modulation of voltage-gated ion channels for the treatment of epilepsy.

  Regardless of the voltage-gated ion channel that is targeted in a drug discovery effort for the treatment of epilepsy, two routes have been followed h…

  Authors: Nicholas D P Cosford, Peter T Meinke, Kenneth A Stauderman, Stephen D Hess

  Source: Current drug targets. CNS and neurological disorders. 2002 Feb

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