1 to 10 of 17 literature results

• Nuclear receptor-enhanced transcription requires motor- and LSD1-dependent gene networking in interchromatin granules.

  While the transcriptional machinery has been extensively dissected at the molecular level, little is known about regulation of chromosomal organizatio…

  Authors: Esperanza Nunez, Young-Soo Kwon, Kasey R Hutt, Qidong Hu, Maria Dafne Cardamone, Kenneth A Ohgi, Ivan Garcia-Bassets, David W Rose, Christopher K Glass, Michael G Rosenfeld,…

  Source: Cell. 2008 Mar 21

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• Histone methylation-dependent mechanisms impose ligand dependency for gene activation by nuclear receptors.

  Nuclear receptors undergo ligand-dependent conformational changes that are required for corepressor-coactivator exchange, but whether there is an actu…

  Authors: Ivan Garcia-Bassets, Young-Soo Kwon, Francesca Telese, Gratien G Prefontaine, Kasey R Hutt, Christine S Cheng, Bong-Gun Ju, Kenneth A Ohgi, Jianxun Wang, Laure Escoubet-Lozach,…

  Source: Cell. 2007 Feb 9

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• Homeodomain-mediated beta-catenin-dependent switching events dictate cell-lineage determination.

  While the biological roles of canonical Wnt/beta-catenin signaling in development and disease are well documented, understanding the molecular logic u…

  Authors: Lorin E Olson, Jessica Tollkuhn, Claudio Scafoglio, Anna Krones, Jie Zhang, Kenneth A Ohgi, Wei Wu, Makoto M Taketo, Rolf Kemler, Rudolf Grosschedl,…

  Source: Cell. 2006 May 5

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• Opposing LSD1 complexes function in developmental gene activation and repression programmes.

  Precise control of transcriptional programmes underlying metazoan development is modulated by enzymatically active co-regulatory complexes, coupled wi…

  Authors: Jianxun Wang, Kathleen Scully, Xiaoyan Zhu, Ling Cai, Jie Zhang, Gratien G Prefontaine, Anna Krones, Kenneth A Ohgi, Ping Zhu, Ivan Garcia-Bassets,…

  Source: Nature. 2007 Apr 19

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• TBL1 and TBLR1 phosphorylation on regulated gene promoters overcomes dual CtBP and NCoR/SMRT transcriptional repression checkpoints.

  A key strategy to achieve regulated gene expression in higher eukaryotes is to prevent illegitimate signal-independent activation by imposing robust c…

  Authors: Valentina Perissi, Claudio Scafoglio, Jie Zhang, Kenneth A Ohgi, David W Rose, Christopher K Glass, Michael G Rosenfeld

  Source: Molecular cell. 2008 Mar 28

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• Histone H2A monoubiquitination represses transcription by inhibiting RNA polymerase II transcriptional elongation.

  Solving the biological roles of covalent histone modifications, including monoubiquitination of histone H2A, and the molecular mechanisms by which the…

  Authors: Wenlai Zhou, Ping Zhu, Jianxun Wang, Gabriel Pascual, Kenneth A Ohgi, Jean Lozach, Christopher K Glass, Michael G Rosenfeld

  Source: Molecular cell. 2008 Jan 18

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• Macrophage/cancer cell interactions mediate hormone resistance by a nuclear receptor derepression pathway.

  Defining the precise molecular strategies that coordinate patterns of transcriptional responses to specific signals is central for understanding norma…

  Authors: Ping Zhu, Sung Hee Baek, Eliot M Bourk, Kenneth A Ohgi, Ivan Garcia-Bassets, Hideki Sanjo, Shizuo Akira, Paul F Kotol, Christopher K Glass, Michael G Rosenfeld,…

  Source: Cell. 2006 Feb 10

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• Transcriptional regulation of a metastasis suppressor gene by Tip60 and beta-catenin complexes.

  Defining the molecular strategies that integrate diverse signalling pathways in the expression of specific gene programmes that are critical in homeos…

  Authors: Jung Hwa Kim, Bogyou Kim, Ling Cai, Hee June Choi, Kenneth A Ohgi, Chris Tran, Charlie Chen, Chin Ha Chung, Otmar Huber, David W Rose,…

  Source: Nature. 2005 Apr 14

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• A histone H2A deubiquitinase complex coordinating histone acetylation and H1 dissociation in transcriptional regulation.

  Deciphering the epigenetic "code" remains a central issue in transcriptional regulation. Here, we report the identification of a JAMM/MPN(+) domain-co…

  Authors: Ping Zhu, Wenlai Zhou, Jianxun Wang, Janusz Puc, Kenneth A Ohgi, Hediye Erdjument-Bromage, Paul Tempst, Christopher K Glass, Michael G Rosenfeld

  Source: Molecular cell. 2007 Aug 17

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• Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein.

  Defining the molecular mechanisms that integrate diverse signaling pathways at the level of gene transcription remains a central issue in biology. Her…

  Authors: Sung Hee Baek, Kenneth A Ohgi, David W Rose, Edward H Koo, Christopher K Glass, Michael G Rosenfeld

  Source: Cell. 2002 Jul 12

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