1 to 10 of 20 literature results

• Dectin-1 is required for beta-glucan recognition and control of fungal infection.

  Beta-glucan is one of the most abundant polysaccharides in fungal pathogens, yet its importance in antifungal immunity is unclear. Here we show that d…

  Authors: Philip R Taylor, S Vicky Tsoni, Janet A Willment, Kevin M Dennehy, Marcela Rosas, Helen Findon, Ken Haynes, Chad Steele, Marina Botto, Siamon Gordon,…

  Source: Nature immunology. 2007 Jan

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• Nitrosative and oxidative stress responses in fungal pathogenicity.

  Fungal pathogenicity has arisen in polyphyletic manner during evolution, yielding fungal pathogens with diverse infection strategies and with differin…

  Authors: Alistair J P Brown, Ken Haynes, Janet Quinn

  Source: Current opinion in microbiology. 2009 Aug

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• Impact of the transcriptional regulator, Ace2, on the Candida glabrata secretome.

  Candida glabrata is a major fungal pathogen of humans, and the virulence of C. glabrata is increased by inactivation of the transcription factor, Ace2…

  Authors: David A Stead, Janet Walker, Lucy Holcombe, Samuel R S Gibbs, Zhikang Yin, Laura Selway, Geraldine Butler, Alistair J P Brown, Ken Haynes

  Source: Proteomics. 2010 Jan

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• The Aspergillus pH-responsive transcription factor PacC regulates virulence.

  The ability of a pathogen to adapt to the host environment is usually required for the initiation of disease. Here we have investigated the importance…

  Authors: Elaine Bignell, Susana Negrete-Urtasun, Ana Maria Calcagno, Ken Haynes, Herbert N Arst, Tom Rogers

  Source: Molecular microbiology. 2005 Feb

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• Different consequences of ACE2 and SWI5 gene disruptions for virulence of pathogenic and nonpathogenic yeasts.

  Mutants of Candida albicans, Candida glabrata, and Saccharomyces cerevisiae with disruptions in the ACE2 gene and C. glabrata and S. cerevisiae swi5 d…

  Authors: Donna M MacCallum, Helen Findon, Claire C Kenny, Geraldine Butler, Ken Haynes, Frank C Odds

  Source: Infection and immunity. 2006 Sep

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• Proteomic changes associated with inactivation of the Candida glabrata ACE2 virulence-moderating gene.

  Inactivation of the gene encoding the transcriptional activator Ace2 in the fungal pathogen Candida glabrata results in an almost 200-fold increase in…

  Authors: David Stead, Helen Findon, Zhikang Yin, Janet Walker, Laura Selway, Philip Cash, Bernard A Dujon, Christophe Hennequin, Alistair J P Brown, Ken Haynes

  Source: Proteomics. 2005 May

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• The Aspergillus fumigatus transcriptional activator CpcA contributes significantly to the virulence of this fungal pathogen.

  We have cloned and characterized the Aspergillus fumigatus cpcA gene encoding the transcriptional activator of the cross-pathway control system of ami…

  Authors: Sven Krappmann, Elaine M Bignell, Utz Reichard, Tom Rogers, Ken Haynes, Gerhard H Braus

  Source: Molecular microbiology. 2004 May

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• Virulence comparisons of Aspergillus nidulans mutants are confounded by the inflammatory response of p47phox-/- mice.

  While investigating the requirement for phagosomal alkalinization in the host defense against pulmonary aspergillosis, we observed high morbidity of p…

  Authors: Elaine Bignell, Susana Negrete-Urtasun, Ana Maria Calcagno, Herbert N Arst, Tom Rogers, Ken Haynes

  Source: Infection and immunity. 2005 Aug

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• Candida glabrata STE12 is required for wild-type levels of virulence and nitrogen starvation induced filamentation.

  The highly conserved fungal Ste12 transcription factor family of proteins play critical roles in the regulation of many cellular processes including m…

  Authors: Ana-Maria Calcagno, Elaine Bignell, Peter Warn, Michael D Jones, David W Denning, Fritz A Mühlschlegel, Thomas R Rogers, Ken Haynes

  Source: Molecular microbiology. 2003 Nov

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• Inactivation of transcription factor gene ACE2 in the fungal pathogen Candida glabrata results in hypervirulence.

  During an infection, the coordinated orchestration of many factors by the invading organism is required for disease to be initiated and to progress. T…

  Authors: Mohammed Kamran, Ana-Maria Calcagno, Helen Findon, Elaine Bignell, Michael D Jones, Peter Warn, Philip Hopkins, David W Denning, Geraldine Butler, Thomas Rogers,…

  Source: Eukaryotic cell. 2004 Apr

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