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1 to 10 of 17 literature results
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HVCN1 modulates BCR signal strength via regulation of BCR-dependent generation of reactive oxygen species.
Voltage-gated proton currents regulate generation of reactive oxygen species (ROS) in phagocytic cells. In B cells, stimulation of the B cell antigen …
Authors: Melania Capasso, Mandeep K Bhamrah, Tom Henley, Robert S Boyd, Claudia Langlais, Kelvin Cain, David Dinsdale, Karen Pulford, Mahmood Khan, Boris Musset,…
Source: Nature immunology. 2010 Mar
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Reconstitution of the death-inducing signaling complex reveals a substrate switch that determines CD95-mediated death or survival.
The death-inducing signaling complex (DISC) is critical for initiation of death-receptor-mediated apoptosis; however, paradoxically, CD95 also signals…
Authors: Michelle A Hughes, Nicholas Harper, Michael Butterworth, Kelvin Cain, Gerald M Cohen, Marion MacFarlane
Source: Molecular cell. 2009 Aug 14
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Loss of thymidine kinase 2 alters neuronal bioenergetics and leads to neurodegeneration.
Mutations of thymidine kinase 2 (TK2), an essential component of the mitochondrial nucleotide salvage pathway, can give rise to mitochondrial DNA (mtD…
Authors: Stefano Bartesaghi, Joanne Betts-Henderson, Kelvin Cain, David Dinsdale, Xiaoshan Zhou, Anna Karlsson, Paolo Salomoni, Pierluigi Nicotera
Source: Human molecular genetics. 2010 Feb 1
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Chemical-induced apoptosis: formation of the Apaf-1 apoptosome.
Many environmental and therapeutic agents initiate apoptotic cell death by inducing the release of cytochrome c from the mitochondria, which activates…
Authors: Kelvin Cain
Source: Drug metabolism reviews. 2003 Nov
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Five members of the CEBP transcription factor family are targeted by recurrent IGH translocations in B-cell precursor acute lymphoblastic leukemia (BCP-ALL).
CCAAT enhancer-binding protein (CEBP) transcription factors play pivotal roles in proliferation and differentiation, including suppression of myeloid …
Authors: Takashi Akasaka, Theodore Balasas, Lisa J Russell, Kei-ji Sugimoto, Aneela Majid, Renata Walewska, E Loraine Karran, David G Brown, Kelvin Cain, Lana Harder,…
Source: Blood. 2007 Apr 15
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Diarylurea compounds inhibit caspase activation by preventing the formation of the active 700-kilodalton apoptosome complex.
The release of mitochondrial proapoptotic proteins into the cytosol is the key event in apoptosis signaling, leading to the activation of caspases. On…
Authors: Ulrik Lademann, Kelvin Cain, Mads Gyrd-Hansen, David Brown, Dan Peters, Marja Jäättelä
Source: Molecular and cellular biology. 2003 Nov
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Early drug safety evaluation: biomarkers, signatures, and fingerprints.
When target organ toxicity arises in animal models during routine drug safety evaluation, it raises several key questions: Is this target organ toxici…
Authors: Ruth Roberts, Kelvin Cain, Beth Coyle, Caroline Freathy, Jean-Francois Leonard, Jean-Charles Gautier
Source: Drug metabolism reviews. 2003 Nov
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The Apaf-1 apoptosome: a large caspase-activating complex.
It is increasingly recognized that many key biological processes, including apoptosis, are carried out within very large multi-protein complexes. Apop…
Authors: Kelvin Cain, Shawn B Bratton, Gerald M Cohen
Source: Biochimie. 2002 Feb-Mar
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Caspase-9 cleavage, do you need it?
Caspase-9, which is activated by association with the Apaf-1 (apoptotic protease-activating factor-1) apoptosome complex, cleaves and activates the do…
Authors: Davina Twiddy, Kelvin Cain
Source: The Biochemical journal. 2007 Jul 1
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Regulation of apoptosis by peroxisome proliferators.
Peroxisome proliferators (PPs) constitute a large and chemically diverse family of non-genotoxic rodent hepatocarcinogens that activate the PP-activat…
Authors: Ruth A Roberts, Cecile Michel, Beth Coyle, Caroline Freathy, Kelvin Cain, Eric Boitier
Source: Toxicology letters. 2004 Apr 1
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