10 literature results

• Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2.

  Adipocyte fatty-acid-binding protein, aP2 (FABP4) is expressed in adipocytes and macrophages, and integrates inflammatory and metabolic responses. Stu…

  Authors: Masato Furuhashi, Gürol Tuncman, Cem Z Görgün, Liza Makowski, Genichi Atsumi, Eric Vaillancourt, Keita Kono, Vladimir R Babaev, Sergio Fazio, MacRae F Linton,…

  Source: Nature. 2007 Jun 21

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• Novel and potent inhibitors of stearoyl-CoA desaturase-1. Part II: Identification of 4-ethylamino-3-(2-hydroxyethoxy)-N-[5-(3-trifluoromethylbenzyl)thiazol-2-yl]benzamide and its biological evaluation.

  The continuing investigation of SAR studies of 3-(2-hydroxyethoxy)-N-(5-benzylthiazol-2-yl)-benzamides as stearoyl-CoA desaturase-1 (SCD-1) inhibitors…

  Authors: Yoshikazu Uto, Tsuneaki Ogata, Yohei Kiyotsuka, Yuriko Miyazawa, Yuko Ueno, Hitoshi Kurata, Tsuneo Deguchi, Makiko Yamada, Nobuaki Watanabe, Toshiyuki Takagi,…

  Source: Bioorganic & medicinal chemistry letters. 2009 Aug 1

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• Novel non-systemic inhibitor of ileal apical Na+-dependent bile acid transporter reduces serum cholesterol levels in hamsters and monkeys.

  1-{7-[(1-(3,5-Diethoxyphenyl)-3-{[(3,5-difluorophenyl)(ethyl)amino]carbonyl}-4-oxo-1,4-dihydroquinolin-7-yl)oxy]heptyl}-1-methylpiperidinium bromide, …

  Authors: Ken Kitayama, Daisuke Nakai, Keita Kono, Arthur Gerritsen van der Hoop, Hitoshi Kurata, Elly C de Wit, Louis H Cohen, Toshimori Inaba, Takafumi Kohama

  Source: European journal of pharmacology. 2006 Jun 6

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• A novel class of apical sodium-dependent bile acid transporter inhibitors: the amphiphilic 4-oxo-1-phenyl-1,4-dihydroquinoline derivatives.

  A series of 4-oxo-1-phenyl-1,4-dihydroquinolines possessing a linker and an ammonio moiety were synthesized and found to inhibit the apical sodium-dep…

  Authors: Hitoshi Kurata, Sayaka Suzuki, Yasuo Ohhata, Takuya Ikeda, Toru Hasegawa, Ken Kitayama, Toshimori Inaba, Keita Kono, Takafumi Kohama

  Source: Bioorganic & medicinal chemistry letters. 2004 Mar 8

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• Ethanol-induced pseudohyphal transition in the cells of Candida tropicalis: participation of phosphoinositide signal transduction.

  Ethanol-induced pseudohyphal development in the cells of Candida tropicalis Pk233 was accompanied by the transient accumulation of inositol 1,4,5-tris…

  Authors: Takahito Suzuki, Kazuo Omi, Takuya Ito, Toshiya Takata, Hideo Kikutsugi, Takaji Fujimura, Keita Kono, Teijiro Kamihara

  Source: FEMS yeast research. 2006 Mar

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• Angiopoietin-like protein3 regulates plasma HDL cholesterol through suppression of endothelial lipase.

  OBJECTIVE: A low level of high-density lipoprotein (HDL) in plasma has been recognized as an aspect of metabolic syndrome and as a crucial risk factor…

  Authors: Mitsuru Shimamura, Morihiro Matsuda, Hiroaki Yasumo, Mitsuyo Okazaki, Kazunori Fujimoto, Keita Kono, Tetsuya Shimizugawa, Yosuke Ando, Ryuta Koishi, Takafumi Kohama,…

  Source: Arteriosclerosis, thrombosis, and vascular biology. 2007 Feb

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• Adipocyte/macrophage fatty acid binding proteins control integrated metabolic responses in obesity and diabetes.

  Fatty acid binding proteins (FABPs) are cytosolic fatty acid chaperones whose biological role and mechanisms of action are not well understood. Here, …

  Authors: Kazuhisa Maeda, Haiming Cao, Keita Kono, Cem Z Gorgun, Masato Furuhashi, Kadir T Uysal, Qiong Cao, Genichi Atsumi, Harry Malone, Bala Krishnan,…

  Source: Cell metabolism. 2005 Feb

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• Ca2+-releasing effect of cerivastatin on the sarcoplasmic reticulum of mouse and rat skeletal muscle fibers.

  We analyzed the effect of HMG-CoA reductase inhibitors on Ca(2+) release from the sarcoplasmic reticulum (SR) using chemically skinned skeletal muscle…

  Authors: Ryotaku Inoue, Mitsuo Tanabe, Keita Kono, Kei Maruyama, Takaaki Ikemoto, Makoto Endo

  Source: Journal of pharmacological sciences. 2003 Nov

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• Ceramide kinase, a novel lipid kinase. Molecular cloning and functional characterization.

  Ceramide-1-phosphate is a sphingolipid metabolite that has been implicated in membrane fusion of brain synaptic vesicles and neutrophil phagolysosome …

  Authors: Masako Sugiura, Keita Kono, Hong Liu, Tetsuya Shimizugawa, Hiroyuki Minekura, Sarah Spiegel, Takafumi Kohama

  Source: The Journal of biological chemistry. 2002 Jun 28

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• Inhibition of recombinant sphingosine kinases by novel inhibitors of microbial origin, F-12509A and B-5354c.

  Authors: Keita Kono, Masako Sugiura, Takafumi Kohama

  Source: The Journal of antibiotics. 2002 Jan

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