1 to 7 of 7 literature results

• Loss of small heterodimer partner expression in the liver protects against dyslipidemia.

  Multiple studies suggest increased conversion of cholesterol to bile acids by cholesterol 7alpha-hydroxylase (CYP7A1) protects against dyslipidemia an…

  Authors: Helen B Hartman, Kehdih Lai, Mark J Evans

  Source: Journal of lipid research. 2009 Feb

  View Full Text

• Improvement of physiochemical properties of the tetrahydroazepinoindole series of farnesoid X receptor (FXR) agonists: beneficial modulation of lipids in primates.

  In an effort to develop orally active farnesoid X receptor (FXR) agonists, a series of tetrahydroazepinoindoles with appended solubilizing amine funct…

  Authors: Joseph T Lundquist, Douglas C Harnish, Callain Y Kim, John F Mehlmann, Rayomand J Unwalla, Kristin M Phipps, Matthew L Crawley, Thomas Commons, Daniel M Green, Weixin Xu,…

  Source: Journal of medicinal chemistry. 2010 Feb 25

  View Full Text

• The nuclear hormone receptor farnesoid X receptor (FXR) is activated by androsterone.

  Farnesoid X receptor (FXR) uses bile acids as endogenous ligands. Here, we demonstrate that androsterone, a metabolic product of testosterone, is also…

  Authors: Shuguang Wang, KehDih Lai, Franklin J Moy, Anitha Bhat, Helen B Hartman, Mark J Evans

  Source: Endocrinology. 2006 Sep

  View Full Text

• Estrogen receptor alpha inhibits IL-1beta induction of gene expression in the mouse liver.

  Estrogens have been suggested to modulate several inflammatory processes. Here, we show that IL-1beta treatment induced the expression of approximatel…

  Authors: Mark J Evans, Kehdih Lai, Lucinda J Shaw, Douglas C Harnish, Christopher C Chadwick

  Source: Endocrinology. 2002 Jul

  View Full Text

• Global transcription profiling of estrogen activity: estrogen receptor alpha regulates gene expression in the kidney.

  Estrogen receptors (ERs) are expressed in numerous organs, although only a few organs are considered classical targets for estrogens. We have complete…

  Authors: Scott A Jelinsky, Heather A Harris, Eugene L Brown, Kathryn Flanagan, Xiaochun Zhang, Christopher Tunkey, KehDih Lai, Malcolm V Lane, Donna K Simcoe, Mark J Evans

  Source: Endocrinology. 2003 Feb

  View Full Text

• A synthetic farnesoid X receptor (FXR) agonist promotes cholesterol lowering in models of dyslipidemia.

  The nuclear hormone receptor farnesoid X receptor (FXR) plays a critical role in the regulation of bile acid, triglyceride (TG), and cholesterol homeo…

  Authors: Mark J Evans, Paige E Mahaney, Lisa Borges-Marcucci, KehDih Lai, Shuguang Wang, Julie A Krueger, Stephen J Gardell, Christine Huard, Robert Martinez, George P Vlasuk,…

  Source: American journal of physiology. Gastrointestinal and liver physiology. 2009 Mar

  View Full Text

• Estrogen receptor alpha regulates expression of the orphan receptor small heterodimer partner.

  Hormonal status can influence diverse metabolic pathways. Small heterodimer partner (SHP) is an orphan nuclear receptor that can modulate the activity…

  Authors: KehDih Lai, Douglas C Harnish, Mark J Evans

  Source: The Journal of biological chemistry. 2003 Sep 19

  View Full Text