1 to 10 of 67 literature results

• SUMOylation of Krüppel-like transcription factor 5 acts as a molecular switch in transcriptional programs of lipid metabolism involving PPAR-delta.

  Obesity and metabolic syndrome are increasingly recognized as major risk factors for cardiovascular disease. Herein we show that Krüppel-like transcri…

  Authors: Yumiko Oishi, Ichiro Manabe, Kazuyuki Tobe, Mitsuru Ohsugi, Tetsuya Kubota, Katsuhito Fujiu, Koji Maemura, Naoto Kubota, Takashi Kadowaki, Ryozo Nagai

  Source: Nature medicine. 2008 Jun

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• Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions.

  Adiponectin plays a central role as an antidiabetic and antiatherogenic adipokine. AdipoR1 and AdipoR2 serve as receptors for adiponectin in vitro, an…

  Authors: Toshimasa Yamauchi, Yasunori Nio, Toshiyuki Maki, Masaki Kobayashi, Takeshi Takazawa, Masato Iwabu, Miki Okada-Iwabu, Sachiko Kawamoto, Naoto Kubota, Tetsuya Kubota,…

  Source: Nature medicine. 2007 Mar

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• Regulatory mechanisms for adipose tissue M1 and M2 macrophages in diet-induced obese mice.

  OBJECTIVE: To characterize the phenotypic changes of adipose tissue macrophages (ATMs) under different conditions of insulin sensitivity. RESEARCH DES…

  Authors: Shiho Fujisaka, Isao Usui, Agussalim Bukhari, Masashi Ikutani, Takeshi Oya, Yukiko Kanatani, Koichi Tsuneyama, Yoshinori Nagai, Kiyoshi Takatsu, Masaharu Urakaze,…

  Source: Diabetes. 2009 Nov

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• Nuclear factor-kappaB decoy oligodeoxynucleotides ameliorate impaired glucose tolerance and insulin resistance in mice with cecal ligation and puncture-induced sepsis.

  OBJECTIVE: Insulin-resistant hyperglycemia is commonly observed in septic patients and may actually lead to some of adverse outcomes. We examined the …

  Authors: Naoyuki Matsuda, Seiji Yamamoto, Hiroki Yokoo, Kazuyuki Tobe, Yuichi Hattori

  Source: Critical care medicine. 2009 Oct

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• Cloning of adiponectin receptors that mediate antidiabetic metabolic effects.

  Adiponectin (also known as 30-kDa adipocyte complement-related protein; Acrp30) is a hormone secreted by adipocytes that acts as an antidiabetic and a…

  Authors: Toshimasa Yamauchi, Junji Kamon, Yusuke Ito, Atsushi Tsuchida, Takehiko Yokomizo, Shunbun Kita, Takuya Sugiyama, Makoto Miyagishi, Kazuo Hara, Masaki Tsunoda,…

  Source: Nature. 2003 Jun 12

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• Adipogenesis in obesity requires close interplay between differentiating adipocytes, stromal cells, and blood vessels.

  OBJECTIVE: The expansion of adipose tissue mass seen in obesity involves both hyperplasia and hypertrophy of adipocytes. However, little is known abou…

  Authors: Satoshi Nishimura, Ichiro Manabe, Mika Nagasaki, Yumiko Hosoya, Hiroshi Yamashita, Hideo Fujita, Mitsuru Ohsugi, Kazuyuki Tobe, Takashi Kadowaki, Ryozo Nagai,…

  Source: Diabetes. 2007 Jun

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• Krüppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling.

  We recently isolated a Krüppel-like zinc-finger transcription factor 5 (KLF5; also known as BTEB2 and IKLF), which is markedly induced in activated va…

  Authors: Takayuki Shindo, Ichiro Manabe, Yasushi Fukushima, Kazuyuki Tobe, Kenichi Aizawa, Saku Miyamoto, Keiko Kawai-Kowase, Nobuo Moriyama, Yasushi Imai, Hayato Kawakami,…

  Source: Nature medicine. 2002 Aug

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• Hepatocyte nuclear factor-4alpha P2 promoter haplotypes are associated with type 2 diabetes in the Japanese population.

  Hepatocyte nuclear factor (HNF)-4alpha is a transcription factor known as a key molecule in the development and functions of the beta-cells. In a prev…

  Authors: Kazuo Hara, Momoko Horikoshi, Hiroji Kitazato, Chikako Ito, Mitsuhiko Noda, Jun Ohashi, Philippe Froguel, Katsushi Tokunaga, Kazuyuki Tobe, Ryozo Nagai,…

  Source: Diabetes. 2006 May

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• IRS-2 branch of IGF-1 receptor signaling is essential for appropriate timing of myelination.

  Insulin-like growth factor (IGF)-1 increases proliferation, inhibits apoptosis and promotes differentiation of oligodendrocytes and their precursor ce…

  Authors: Susanna Freude, Uschi Leeser, Marita Müller, Moritz M Hettich, Michael Udelhoven, Katharina Schilbach, Kazuyuki Tobe, Takashi Kadowaki, Christoph Köhler, Hannsjörg Schröder,…

  Source: Journal of neurochemistry. 2008 Nov

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• Lack of insulin receptor substrate-2 causes progressive neointima formation in response to vessel injury.

  BACKGROUND: Insulin resistance is associated with atherosclerosis, but its mechanism is unknown. It has been reported that insulin receptor substrate …

  Authors: Tetsuya Kubota, Naoto Kubota, Masao Moroi, Yasuo Terauchi, Tsuneo Kobayashi, Katsuo Kamata, Ryo Suzuki, Kazuyuki Tobe, Atsushi Namiki, Shinichi Aizawa,…

  Source: Circulation. 2003 Jun 24

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