1 to 10 of 12 literature results

• Identification of genes that regulate epithelial cell migration using an siRNA screening approach.

  To provide a systematic analysis of genes that regulate epithelial cell migration, we performed a high throughput wound healing screen with MCF-10A br…

  Authors: Kaylene J Simpson, Laura M Selfors, James Bui, Angela Reynolds, Devin Leake, Anastasia Khvorova, Joan S Brugge

  Source: Nature cell biology. 2008 Sep

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• Generation of a functional mammary gland from a single stem cell.

  The existence of mammary stem cells (MaSCs) has been postulated from evidence that the mammary gland can be regenerated by transplantation of epitheli…

  Authors: Mark Shackleton, François Vaillant, Kaylene J Simpson, John Stingl, Gordon K Smyth, Marie-Liesse Asselin-Labat, Li Wu, Geoffrey J Lindeman, Jane E Visvader

  Source: Nature. 2006 Jan 5

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• FOXO3a promotes tumor cell invasion through the induction of matrix metalloproteinases.

  The role of the Forkhead transcription factor FOXO3a in processes that promote tumor metastasis is poorly defined. Here, we show that depletion of FOX…

  Authors: Peter Storz, Heike Döppler, John A Copland, Kaylene J Simpson, Alex Toker

  Source: Molecular and cellular biology. 2009 Sep

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• Functional analysis of the contribution of RhoA and RhoC GTPases to invasive breast carcinoma.

  Although the RhoA and RhoC proteins comprise an important subset of the Rho GTPase family that have been implicated in invasive breast carcinomas, att…

  Authors: Kaylene J Simpson, Aisling S Dugan, Arthur M Mercurio

  Source: Cancer research. 2004 Dec 1

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• Posttranscriptional regulation of the breast cancer susceptibility gene BRCA1 by the RNA binding protein HuR.

  BRCA1 is a breast cancer susceptibility gene that is down-regulated in a significant proportion of sporadic breast cancers. BRCA1 is posttranscription…

  Authors: Jodi M Saunus, Juliet D French, Stacey L Edwards, Dianne J Beveridge, Esme C Hatchell, Sarah A Wagner, Sandra R Stein, Andrew Davidson, Kaylene J Simpson, Glenn D Francis,…

  Source: Cancer research. 2008 Nov 15

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• The alpha6beta4 integrin maintains the survival of human breast carcinoma cells in vivo.

  The alpha6beta4 integrin has been widely implicated in carcinoma function in vitro; however, in vivo data are scarce. To determine the importance of a…

  Authors: Elizabeth A Lipscomb, Kaylene J Simpson, Stephen R Lyle, Jennifer E Ring, Aisling S Dugan, Arthur M Mercurio

  Source: Cancer research. 2005 Dec 1

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• Brca1 inactivation induces p27(Kip1)-dependent cell cycle arrest and delayed development in the mouse mammary gland.

  One common characteristic of breast cancers arising in carriers of the predisposition gene BRCA1 is a loss of expression of the CDK inhibitor p27(Kip1…

  Authors: Andrew J Deans, Kaylene J Simpson, Melanie K Trivett, Melissa A Brown, Grant A McArthur

  Source: Oncogene. 2004 Aug 12

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• The comparative biology of whey proteins.

  Lactational strategies and associated development of the young have been studied in a diverse range of species, and comparative analysis allows common…

  Authors: Kaylene J Simpson, Kevin R Nicholas

  Source: Journal of mammary gland biology and neoplasia. 2002 Jul

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• Maternal regulation of milk composition, milk production, and pouch young development during lactation in the tammar wallaby (Macropus eugenii ).

  Specific changes in milk composition during lactation in the tammar wallaby (Macropus eugenii) were correlated with the ages of the developing pouch y…

  Authors: Josephine F Trott, Kaylene J Simpson, Richard L C Moyle, Cyrma M Hearn, Geoffrey Shaw, Kevin R Nicholas, Marilyn B Renfree

  Source: Biology of reproduction. 2003 Mar

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• Regulation of cell adhesion and collective cell migration by hindsight and its human homolog RREB1.

  Cell movements represent a major driving force in embryonic development, tissue repair, and tumor metastasis [1]. The migration of single cells has be…

  Authors: Mariana Melani, Kaylene J Simpson, Joan S Brugge, Denise Montell

  Source: Current biology : CB. 2008 Apr 8

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