1 to 9 of 9 literature results

• Placental and embryonic growth restriction in mice with reduced function epidermal growth factor receptor alleles.

  Embryos lacking an epidermal growth factor receptor (EGFR) exhibit strain-specific defects in placental development that can result in mid-gestational…

  Authors: Jennifer Dackor, Kathleen M Caron, David W Threadgill

  Source: Genetics. 2009 Sep

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• Haploinsufficiency for adrenomedullin reduces pinopodes and diminishes uterine receptivity in mice.

  Adrenomedullin (AM) is a multifunctional peptide vasodilator that signals through a G-protein-coupled receptor when the receptor, called calcitonin re…

  Authors: Manyu Li, Yongqin Wu, Kathleen M Caron

  Source: Biology of reproduction. 2008 Dec

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• Hydrops fetalis, cardiovascular defects, and embryonic lethality in mice lacking the calcitonin receptor-like receptor gene.

  Adrenomedullin (AM) is a multifunctional peptide vasodilator that is essential for life. To date, numerous in vitro studies have suggested that AM can…

  Authors: Ryan T Dackor, Kimberly Fritz-Six, William P Dunworth, Carrie L Gibbons, Oliver Smithies, Kathleen M Caron

  Source: Molecular and cellular biology. 2006 Apr

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• Adrenomedullin stabilizes the lymphatic endothelial barrier in vitro and in vivo.

  The lymphatic vascular system functions to maintain fluid homeostasis by removing fluid from the interstitial space and returning it to venous circula…

  Authors: William P Dunworth, Kimberly L Fritz-Six, Kathleen M Caron

  Source: Peptides. 2008 Dec

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• Multiple roles of adrenomedullin revealed by animal models.

  The newly identified adrenomedullin (AM) gene codes for a potent, highly conserved vasodilator that is expressed in many tissues. Many biological func…

  Authors: Kathleen M Caron, Oliver Smithies

  Source: Microscopy research and technique. 2002 Apr 1

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• G protein-coupled receptors as potential drug targets for lymphangiogenesis and lymphatic vascular diseases.

  G protein-coupled receptors (GPCRs) are widely expressed cell surface receptors that have been successfully exploited for the treatment of a variety o…

  Authors: William P Dunworth, Kathleen M Caron

  Source: Arteriosclerosis, thrombosis, and vascular biology. 2009 May

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• Adrenomedullin signaling is necessary for murine lymphatic vascular development.

  The lymphatic vascular system mediates fluid homeostasis, immune defense, and tumor metastasis. Only a handful of genes are known to affect the develo…

  Authors: Kimberly L Fritz-Six, William P Dunworth, Manyu Li, Kathleen M Caron

  Source: The Journal of clinical investigation. 2008 Jan

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• Receptor activity-modifying proteins: RAMPing up adrenomedullin signaling.

  Adrenomedullin (AM) is a 52-amino-acid multifunctional peptide that circulates in the plasma in the low picomolar range and can exert a multitude of b…

  Authors: Carrie Gibbons, Ryan Dackor, William Dunworth, Kimberly Fritz-Six, Kathleen M Caron

  Source: Molecular endocrinology (Baltimore, Md.). 2007 Apr

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• Reduced maternal expression of adrenomedullin disrupts fertility, placentation, and fetal growth in mice.

  Adrenomedullin (AM) is a multifunctional peptide vasodilator that is essential for life. Plasma AM expression dramatically increases during pregnancy,…

  Authors: Manyu Li, Della Yee, Terry R Magnuson, Oliver Smithies, Kathleen M Caron

  Source: The Journal of clinical investigation. 2006 Oct

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