1 to 10 of 25 literature results

• Multiple organ pathology, metabolic abnormalities and impaired homeostasis of reactive oxygen species in Epas1-/- mice.

  Hypoxia-inducible factor (HIF) transcription factors respond to multiple environmental stressors, including hypoxia and hypoglycemia. We report that m…

  Authors: Marzia Scortegagna, Kan Ding, Yavuz Oktay, Arti Gaur, Frederick Thurmond, Liang-Jun Yan, Brett T Marck, Alvin M Matsumoto, John M Shelton, James A Richardson,…

  Source: Nature genetics. 2003 Dec

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• A polysaccharide, MDG-1, induces S1P1 and bFGF expression and augments survival and angiogenesis in the ischemic heart.

  Ophiopogon japonicus is a traditional Chinese medicine used to treat cardiovascular disease. Recent studies have confirmed its beneficial properties, …

  Authors: Shuo Wang, Zhang Zhang, Xiao Lin, De-Sheng Xu, Yi Feng, Kan Ding

  Source: Glycobiology. 2010 Jan

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• Characterization of A pectic polysaccharide from the leaves of diospyros kaki and its modulating activity on lymphocyte proliferation.

  Pectin is a group of carbohydrate polymers constructing the primary cell walls and the middle lamella of terrestrial plants. Herein we demonstrated th…

  Authors: Jinyou Duan, Qun Dong, Kan Ding, Jinian Fang

  Source: Biopolymers. 2010 Mar 16

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• HIF-2alpha regulates murine hematopoietic development in an erythropoietin-dependent manner.

  Erythropoiesis in the adult mammal depends critically on erythropoietin, an inducible cytokine with pluripotent effects. Erythropoietin gene expressio…

  Authors: Marzia Scortegagna, Kan Ding, Quiyang Zhang, Yavuz Oktay, Michael J Bennett, Michael Bennett, John M Shelton, James A Richardson, Orson Moe, Joseph A Garcia

  Source: Blood. 2005 Apr 15

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• HIF-2alpha-haploinsufficient mice have blunted retinal neovascularization due to impaired expression of a proangiogenic gene battery.

  PURPOSE: To characterize the effect of HIF-2alpha haploinsufficiency on retinal neovascularization and angiogenic signaling in neonatal mice. METHODS:…

  Authors: Elhadji M Dioum, Stephen L Clarke, Kan Ding, Joyce J Repa, Joseph A Garcia

  Source: Investigative ophthalmology & visual science. 2008 Jun

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• Waltonitone induces human hepatocellular carcinoma cells apoptosis in vitro and in vivo.

  Waltonitone, a new ursane-type pentacyclic triterpene isolated from Gentian waltonii Burkill significantly inhibited human hepatocellular carcinoma BE…

  Authors: Zhang Zhang, Shuo Wang, Hong Qiu, Chaohui Duan, Kan Ding, Zhengtao Wang

  Source: Cancer letters. 2009 Dec 28

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• New oligosaccharides prepared by acid hydrolysis of the polysaccharides from Nerium indicum Mill and their anti-angiogenesis activities.

  To discover drug candidates with anti-angiogenesis activity for cancer therapeutics, three galactooligosaccharides (OJ1-OJ3) were prepared by acid hyd…

  Authors: Ke Hu, Qin Liu, Shunchun Wang, Kan Ding

  Source: Carbohydrate research. 2009 Jan 26

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• Distribution of sphingosine kinase activity and mRNA in rodent brain.

  Sphingosine-1-phosphate (S1P) is a lipid mediator that exerts multiple cellular functions through activation of a subfamily of G-protein-coupled recep…

  Authors: Nicolas Blondeau, Yushuan Lai, Sarah Tyndall, Margherita Popolo, Kamil Topalkara, James K Pru, Ling Zhang, Hyunghwan Kim, James K Liao, Kan Ding,…

  Source: Journal of neurochemistry. 2007 Oct

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• Retinal disease in mice lacking hypoxia-inducible transcription factor-2alpha.

  PURPOSE: To characterize ocular disease in HIF-2alpha-null mice. METHODS: Histologic, electroretinographic (ERG), and molecular studies were performed…

  Authors: Kan Ding, Marzia Scortegagna, Robyn Seaman, David G Birch, Joseph A Garcia

  Source: Investigative ophthalmology & visual science. 2005 Mar

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• Diffusion tensor tractography of traumatic diffuse axonal injury.

  BACKGROUND: Diffuse axonal injury is a common consequence of traumatic brain injury that frequently involves the parasagittal white matter, corpus cal…

  Authors: Jun Yi Wang, Khamid Bakhadirov, Michael D Devous, Hervé Abdi, Roddy McColl, Carol Moore, Carlos D Marquez de la Plata, Kan Ding, Anthony Whittemore, Evelyn Babcock,…

  Source: Archives of neurology. 2008 May

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