1 to 10 of 57 literature results

• The roles of eotaxin and the STAT6 signalling pathway in eosinophil recruitment and host resistance to the nematodes Nippostrongylus brasiliensis and Heligmosomoides bakeri.

  Expulsion of adult Nippostrongylus brasiliensis worms from the small intestine is profoundly impaired in signal transducer and activator of transcript…

  Authors: M L Knott, K I Matthaei, P S Foster, L A Dent

  Source: Molecular immunology. 2009 Aug

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• FVB/N mice are highly resistant to primary infection with Nippostrongylus brasiliensis.

  Nippostrongylus brasiliensis larvae are particularly susceptible to immunological attack during the pre-lung stage of primary and secondary infections…

  Authors: M L Knott, S P Hogan, H Wang, K I Matthaei, L A Dent

  Source: Parasitology. 2009 Jan

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• Enhanced effect of dopaminergic stimulation on prepulse inhibition in mice deficient in the alpha subunit of G(z).

  RATIONALE: G(z) is a member of the G(i) G protein family associated with dopamine D2-like receptors; however, its functions remain relatively unknown.…

  Authors: M van den Buuse, S Martin, J Brosda, K J Leck, K I Matthaei, I Hendry

  Source: Psychopharmacology. 2005 Dec

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• Deletion of guanine nucleotide binding protein alpha z subunit in mice induces a gene dose dependent tolerance to morphine.

  The mechanism underlying the development of tolerance to morphine is still incompletely understood. Morphine binds to opioid receptors, which in turn …

  Authors: K J Leck, S E Bartlett, M T Smith, D Megirian, J Holgate, K L Powell, K I Matthaei, I A Hendry

  Source: Neuropharmacology. 2004 May

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• Targeted disruption of the mouse Gz-alpha gene: a role for Gz in platelet function?

  Gz is one of nine G proteins identified in platelets and its role in these cells is unknown. Our laboratory has generated a mouse deficient in the Gz-…

  Authors: K L Kelleher, K I Matthaei, I A Hendry

  Source: Thrombosis and haemostasis. 2001 Mar

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• Interleukin-5-producing CD4+ T cells play a pivotal role in aeroallergen-induced eosinophilia, bronchial hyperreactivity, and lung damage in mice.

  Although activated CD4+ T cells have been implicated in the pathogenesis of asthma, the direct contribution of this leukocyte to the induction of aero…

  Authors: S P Hogan, A Koskinen, K I Matthaei, I G Young, P S Foster

  Source: American journal of respiratory and critical care medicine. 1998 Jan

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• Elemental signals regulating eosinophil accumulation in the lung.

  In this review we identify the elemental signals that regulate eosinophil accumulation in the allergic lung. We show that there are two interwoven mec…

  Authors: P S Foster, A W Mould, M Yang, J Mackenzie, J Mattes, S P Hogan, S Mahalingam, A N Mckenzie, M E Rothenberg, I G Young,…

  Source: Immunological reviews. 2001 Feb

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• Allergic sensitization is enhanced in early life through toll-like receptor 7 activation.

  BACKGROUND: Prospective cohort studies suggest that children hospitalized in early life with severe infections are significantly more likely to develo…

  Authors: S Phipps, N Hansbro, C E Lam, S Y Foo, K I Matthaei, P S Foster

  Source: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 2009 Dec

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• Interleukin-13 mediates airways hyperreactivity through the IL-4 receptor-alpha chain and STAT-6 independently of IL-5 and eotaxin.

  Interleukin (IL)-13 is a central mediator of the processes underlying the induction of airways hyperreactivity (AHR) in the allergic lung. However, th…

  Authors: M Yang, S P Hogan, P J Henry, K I Matthaei, A N McKenzie, I G Young, M E Rothenberg, P S Foster

  Source: American journal of respiratory cell and molecular biology. 2001 Oct

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• A role for IL-5 in the induction of cytotoxic T lymphocytes in vivo.

  IL-5 is generally regarded as a Th2 cytokine involved in eosinophil maturation and function and in B cell growth and antibody production, but without …

  Authors: V Apostolopoulos, I F McKenzie, C Lees, K I Matthaei, I G Young

  Source: European journal of immunology. 2000 Jun

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