1 to 6 of 6 literature results

• PPAR-delta senses and orchestrates clearance of apoptotic cells to promote tolerance.

  Macrophages rapidly engulf apoptotic cells to limit the release of noxious cellular contents and to restrict autoimmune responses against self antigen…

  Authors: Lata Mukundan, Justin I Odegaard, Christine R Morel, Jose E Heredia, Julia W Mwangi, Roberto R Ricardo-Gonzalez, Y P Sharon Goh, Alex Red Eagle, Shannon E Dunn, Jennifer U H Awakuni,…

  Source: Nature medicine. 2009 Nov

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• Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance.

  Obesity and insulin resistance, the cardinal features of metabolic syndrome, are closely associated with a state of low-grade inflammation. In adipose…

  Authors: Justin I Odegaard, Roberto R Ricardo-Gonzalez, Matthew H Goforth, Christine R Morel, Vidya Subramanian, Lata Mukundan, Alex Red Eagle, Divya Vats, Frank Brombacher, Anthony W Ferrante,…

  Source: Nature. 2007 Jun 28

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• Quantitative expansion of ES cell-derived myeloid progenitors capable of differentiating into macrophages.

  Macrophages participate in physiologic and pathologic processes through elaboration of distinct activation programs. Studies with macrophage cell syst…

  Authors: Justin I Odegaard, Divya Vats, Lina Zhang, Roberto Ricardo-Gonzalez, Kristi L Smith, David B Sykes, Mark P Kamps, Ajay Chawla

  Source: Journal of leukocyte biology. 2007 Mar

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• Mechanisms of macrophage activation in obesity-induced insulin resistance.

  Chronic inflammation is now recognized as a key step in the pathogenesis of obesity-induced insulin resistance and type 2 diabetes mellitus. This low-…

  Authors: Justin I Odegaard, Ajay Chawla

  Source: Nature clinical practice. Endocrinology & metabolism. 2008 Nov

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• Alternative M2 activation of Kupffer cells by PPARdelta ameliorates obesity-induced insulin resistance.

  Macrophage infiltration and activation in metabolic tissues underlie obesity-induced insulin resistance and type 2 diabetes. While inflammatory activa…

  Authors: Justin I Odegaard, Roberto R Ricardo-Gonzalez, Alex Red Eagle, Divya Vats, Christine R Morel, Matthew H Goforth, Vidya Subramanian, Lata Mukundan, Anthony W Ferrante, Ajay Chawla

  Source: Cell metabolism. 2008 Jun

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• Oxidative metabolism and PGC-1beta attenuate macrophage-mediated inflammation.

  Complex interplay between T helper (Th) cells and macrophages contributes to the formation and progression of atherosclerotic plaques. While Th1 cytok…

  Authors: Divya Vats, Lata Mukundan, Justin I Odegaard, Lina Zhang, Kristi L Smith, Christine R Morel, Roger A Wagner, David R Greaves, Peter J Murray, Ajay Chawla

  Source: Cell metabolism. 2006 Jul

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