1 to 10 of 118 literature results

• Protein kinase DYRK2 is a scaffold that facilitates assembly of an E3 ligase.

  Protein kinases have central functions in various cellular signal transduction pathways through their substrate phosphorylation. Here we show that a p…

  Authors: Subbareddy Maddika, Junjie Chen

  Source: Nature cell biology. 2009 Apr

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• DBC1 is a negative regulator of SIRT1.

  The NAD-dependent protein deacetylase Sir2 (silent information regulator 2) regulates lifespan in several organisms. SIRT1, the mammalian orthologue o…

  Authors: Ja-Eun Kim, Junjie Chen, Zhenkun Lou

  Source: Nature. 2008 Jan 31

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• DNA-damage checkpoints: location, location, location.

  The DNA-damage response (DDR) is an evolutionarily conserved signaling cascade crucial for sensing DNA damage and activating cellular responses such a…

  Authors: Jamie L Wood, Junjie Chen

  Source: Trends in cell biology. 2008 Oct

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• The annealing helicase HARP protects stalled replication forks.

  Mutations in HepA-related protein (HARP) are the only identified causes of Schimke immunoosseous dysplasia (SIOD). HARP has a unique annealing helicas…

  Authors: Jingsong Yuan, Gargi Ghosal, Junjie Chen

  Source: Genes & development. 2009 Oct 15

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• Topoisomerase IIalpha controls the decatenation checkpoint.

  Topoisomerase II (Topo II) is required to separate intertwined sister chromatids before chromosome segregation can occur in mitosis. However, it remai…

  Authors: Kuntian Luo, Jian Yuan, Junjie Chen, Zhenkun Lou

  Source: Nature cell biology. 2009 Feb

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• Assembly of checkpoint and repair machineries at DNA damage sites.

  The remarkably coordinated nature of the DNA damage response pathway relies on numerous mechanisms that facilitate the assembly of checkpoint and repa…

  Authors: Michael S Y Huen, Junjie Chen

  Source: Trends in biochemical sciences. 2009 Oct 27

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• SOSS complexes participate in the maintenance of genomic stability.

  Proteins that bind to single-stranded DNA (ssDNA) are essential for DNA replication, recombinational repair, and maintenance of genomic stability. Her…

  Authors: Jun Huang, Zihua Gong, Gargi Ghosal, Junjie Chen

  Source: Molecular cell. 2009 Aug 14

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• MERIT40 facilitates BRCA1 localization and DNA damage repair.

  The product of breast cancer susceptibility gene 1, BRCA1, plays pivotal roles in the maintenance of genomic integrity. Mounting evidence indicates th…

  Authors: Lin Feng, Jun Huang, Junjie Chen

  Source: Genes & development. 2009 Mar 15

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• RAD18 transmits DNA damage signalling to elicit homologous recombination repair.

  To maintain genome stability, cells respond to DNA damage by activating signalling pathways that govern cell-cycle checkpoints and initiate DNA repair…

  Authors: Jun Huang, Michael S Y Huen, Hongtae Kim, Charles Chung Yun Leung, J N Mark Glover, Xiaochun Yu, Junjie Chen

  Source: Nature cell biology. 2009 May

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• RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly.

  DNA-damage signaling utilizes a multitude of posttranslational modifiers as molecular switches to regulate cell-cycle checkpoints, DNA repair, cellula…

  Authors: Michael S Y Huen, Robert Grant, Isaac Manke, Kay Minn, Xiaochun Yu, Michael B Yaffe, Junjie Chen

  Source: Cell. 2007 Nov 30

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