1 to 10 of 11 literature results

• Nuclear receptor ERR alpha and coactivator PGC-1 beta are effectors of IFN-gamma-induced host defense.

  Macrophage activation by the proinflammatory cytokine interferon-gamma (IFN-gamma) is a critical component of the host innate response to bacterial pa…

  Authors: Junichiro Sonoda, Josée Laganière, Isaac R Mehl, Grant D Barish, Ling-Wa Chong, Xiangli Li, Immo E Scheffler, Dennis C Mock, Alain R Bataille, Francois Robert,…

  Source: Genes & development. 2007 Aug 1

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• Nuclear receptors: decoding metabolic disease.

  Nuclear receptors (NR) are a superfamily of ligand-activated transcription factors that regulate development, reproduction, and metabolism of lipids, …

  Authors: Junichiro Sonoda, Liming Pei, Ronald M Evans

  Source: FEBS letters. 2008 Jan 9

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• Effects of naturally occurring coumarins on hepatic drug-metabolizing enzymes in mice.

  Cytochromes P450 (P450s) and glutathione S-transferases (GSTs) constitute two important enzyme families involved in carcinogen metabolism. Generally, …

  Authors: Heather E Kleiner, Xiaojun Xia, Junichiro Sonoda, Jun Zhang, Elizabeth Pontius, Jane Abey, Ronald M Evans, David D Moore, John DiGiovanni

  Source: Toxicology and applied pharmacology. 2008 Oct 15

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• A novel constitutive androstane receptor-mediated and CYP3A-independent pathway of bile acid detoxification.

  Cytosolic sulfotransferase (SULT)-mediated sulfation plays an essential role in the detoxification of bile acids and is necessary to avoid pathologica…

  Authors: Simrat P S Saini, Junichiro Sonoda, Li Xu, David Toma, Hirdesh Uppal, Ying Mu, Songrong Ren, David D Moore, Ronald M Evans, Wen Xie

  Source: Molecular pharmacology. 2004 Feb

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• PGC-1beta controls mitochondrial metabolism to modulate circadian activity, adaptive thermogenesis, and hepatic steatosis.

  The transcriptional coactivator peroxisome proliferator-activated receptor-gamma coactivator 1beta (PGC-1beta) is believed to control mitochondrial ox…

  Authors: Junichiro Sonoda, Isaac R Mehl, Ling-Wa Chong, Russell R Nofsinger, Ronald M Evans

  Source: Proceedings of the National Academy of Sciences of the United States of America. 2007 Mar 20

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• Benefit of farnesoid X receptor inhibition in obstructive cholestasis.

  The nuclear hormone receptors farnesoid X receptor (FXR) and pregnane X receptor have been implicated in regulating bile acid, lipid, carbohydrate, an…

  Authors: Catherine Stedman, Christopher Liddle, Sally Coulter, Junichiro Sonoda, Jacqueline G Alvarez, Ronald M Evans, Michael Downes

  Source: Proceedings of the National Academy of Sciences of the United States of America. 2006 Jul 25

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• HTLV-1 provirus load in peripheral blood lymphocytes of HTLV-1 carriers is diminished by green tea drinking.

  Human T-cell lymphotropic virus type 1 (HTLV-1) is causatively associated with adult T-cell leukemia (ATL) and HTLV-1-associated myelopathy/tropical s…

  Authors: Junichiro Sonoda, Chihaya Koriyama, Shinako Yamamoto, Tomohiro Kozako, Hong Chuan Li, Carolina Lema, Shinji Yashiki, Toshinobu Fujiyoshi, Mitsuhiro Yoshinaga, Yukihiro Nagata,…

  Source: Cancer science. 2004 Jul

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• Pregnane X receptor prevents hepatorenal toxicity from cholesterol metabolites.

  Efficient detoxification and clearance of cholesterol metabolites such as oxysterols, bile alcohols, and bile acids are critical for survival because …

  Authors: Junichiro Sonoda, Ling Wa Chong, Michael Downes, Grant D Barish, Sally Coulter, Christopher Liddle, Chih-Hao Lee, Ronald M Evans

  Source: Proceedings of the National Academy of Sciences of the United States of America. 2005 Feb 8

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• Nuclear receptors constitutive androstane receptor and pregnane X receptor ameliorate cholestatic liver injury.

  Cholestasis is associated with accumulation of bile acids and lipids, and liver injury. The constitutive androstane receptor (CAR) and pregnane X rece…

  Authors: Catherine A M Stedman, Christopher Liddle, Sally A Coulter, Junichiro Sonoda, Jacqueline G A Alvarez, David D Moore, Ronald M Evans, Michael Downes

  Source: Proceedings of the National Academy of Sciences of the United States of America. 2005 Feb 8

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• Liquid chromatographic determination of dicarboxylic acids based on intramolecular excimer-forming fluorescence derivatization.

  A highly sensitive and selective fluorimetric determination method for dicarboxylic acids (C5-C12) has been developed. This method is based on an intr…

  Authors: Hitoshi Nohta, Junichiro Sonoda, Hideyuki Yoshida, Hiroshi Satozono, Junichi Ishida, Masatoshi Yamaguchi

  Source: Journal of chromatography. A. 2003 Aug 22

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