Click on one of these terms to refine your search
1 to 10 of 17 literature results
Prostate cancer (CaP) progresses from prostatic intraepithelial neoplasia through locally invasive adenocarcinoma to castration-resistant metastatic c…
Authors: Massimo Ammirante, Jun-Li Luo, Sergei Grivennikov, Sergei Nedospasov, Michael Karin
Source: Nature. 2010 Mar 11
View Full TextMetastatic progression depends on genetic alterations intrinsic to cancer cells as well as the inflammatory microenvironment of advanced tumours. To u…
Authors: Sunhwa Kim, Hiroyuki Takahashi, Wan-Wan Lin, Pascal Descargues, Sergei Grivennikov, Youngjun Kim, Jun-Li Luo, Michael Karin
Source: Nature. 2009 Jan 1
View Free Full TextHistone H3 lysine 4 methylation (H3K4me) has been proposed as a critical component in regulating gene expression, epigenetic states, and cellular iden…
Authors: Gang G Wang, Jikui Song, Zhanxin Wang, Holger L Dormann, Fabio Casadio, Haitao Li, Jun-Li Luo, Dinshaw J Patel, C David Allis
Source: Nature. 2009 Jun 11
View Free Full TextInflammation enhances tumour promotion through NF-kappaB-dependent mechanisms. NF-kappaB was also proposed to promote metastatogenesis through epithel…
Authors: Jun-Li Luo, Wei Tan, Jill M Ricono, Olexandr Korchynskyi, Ming Zhang, Steven L Gonias, David A Cheresh, Michael Karin
Source: Nature. 2007 Apr 5
View Full TextThe proinflammatory cytokine tumor necrosis factor (TNF) alpha signals both cell survival and death. The biological outcome of TNFalpha treatment is d…
Authors: Lufen Chang, Hideaki Kamata, Giovanni Solinas, Jun-Li Luo, Shin Maeda, K Venuprasad, Yun-Cai Liu, Michael Karin
Source: Cell. 2006 Feb 10
View Full TextIkappaB kinase beta (IKKbeta), required for NF-kappaB activation, links chronic inflammation with carcinogenesis. We investigated whether IKKbeta is i…
Authors: Shin Maeda, Hideaki Kamata, Jun-Li Luo, Hyam Leffert, Michael Karin
Source: Cell. 2005 Jul 1
View Full TextMacrophages are pivotal constituents of the innate immune system, vital for recognition and elimination of microbial pathogens. Macrophages use Toll-l…
Authors: Li-Chung Hsu, Jin Mo Park, Kezhong Zhang, Jun-Li Luo, Shin Maeda, Randal J Kaufman, Lars Eckmann, Donald G Guiney, Michael Karin
Source: Nature. 2004 Mar 18
View Full TextWe used an experimental murine cancer metastasis model in which a colon adenocarcinoma cell line generates lung metastases, whose growth is stimulated…
Authors: Jun-Li Luo, Shin Maeda, Li-Chung Hsu, Hideo Yagita, Michael Karin
Source: Cancer cell. 2004 Sep
View Full TextIkappaB kinase beta (IKKbeta) is required for NF-kappaB activation and suppression of TNFalpha-mediated liver apoptosis. To investigate how IKKbeta su…
Authors: Shin Maeda, Lufen Chang, Zhi-Wei Li, Jun-Li Luo, Hyam Leffert, Michael Karin
Source: Immunity. 2003 Nov
View Full TextThe most extensively studied function of NF-kappaB is its ability to promote cell survival through induction of target genes, whose products inhibit v…
Authors: Jun-Li Luo, Hideaki Kamata, Michael Karin
Source: Journal of clinical immunology. 2005 Nov
View Full Text