1 to 10 of 17 literature results

• B-cell-derived lymphotoxin promotes castration-resistant prostate cancer.

  Prostate cancer (CaP) progresses from prostatic intraepithelial neoplasia through locally invasive adenocarcinoma to castration-resistant metastatic c…

  Authors: Massimo Ammirante, Jun-Li Luo, Sergei Grivennikov, Sergei Nedospasov, Michael Karin

  Source: Nature. 2010 Mar 11

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• Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis.

  Metastatic progression depends on genetic alterations intrinsic to cancer cells as well as the inflammatory microenvironment of advanced tumours. To u…

  Authors: Sunhwa Kim, Hiroyuki Takahashi, Wan-Wan Lin, Pascal Descargues, Sergei Grivennikov, Youngjun Kim, Jun-Li Luo, Michael Karin

  Source: Nature. 2009 Jan 1

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• Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger.

  Histone H3 lysine 4 methylation (H3K4me) has been proposed as a critical component in regulating gene expression, epigenetic states, and cellular iden…

  Authors: Gang G Wang, Jikui Song, Zhanxin Wang, Holger L Dormann, Fabio Casadio, Haitao Li, Jun-Li Luo, Dinshaw J Patel, C David Allis

  Source: Nature. 2009 Jun 11

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• Nuclear cytokine-activated IKKalpha controls prostate cancer metastasis by repressing Maspin.

  Inflammation enhances tumour promotion through NF-kappaB-dependent mechanisms. NF-kappaB was also proposed to promote metastatogenesis through epithel…

  Authors: Jun-Li Luo, Wei Tan, Jill M Ricono, Olexandr Korchynskyi, Ming Zhang, Steven L Gonias, David A Cheresh, Michael Karin

  Source: Nature. 2007 Apr 5

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• The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover.

  The proinflammatory cytokine tumor necrosis factor (TNF) alpha signals both cell survival and death. The biological outcome of TNFalpha treatment is d…

  Authors: Lufen Chang, Hideaki Kamata, Giovanni Solinas, Jun-Li Luo, Shin Maeda, K Venuprasad, Yun-Cai Liu, Michael Karin

  Source: Cell. 2006 Feb 10

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• IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis.

  IkappaB kinase beta (IKKbeta), required for NF-kappaB activation, links chronic inflammation with carcinogenesis. We investigated whether IKKbeta is i…

  Authors: Shin Maeda, Hideaki Kamata, Jun-Li Luo, Hyam Leffert, Michael Karin

  Source: Cell. 2005 Jul 1

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• The protein kinase PKR is required for macrophage apoptosis after activation of Toll-like receptor 4.

  Macrophages are pivotal constituents of the innate immune system, vital for recognition and elimination of microbial pathogens. Macrophages use Toll-l…

  Authors: Li-Chung Hsu, Jin Mo Park, Kezhong Zhang, Jun-Li Luo, Shin Maeda, Randal J Kaufman, Lars Eckmann, Donald G Guiney, Michael Karin

  Source: Nature. 2004 Mar 18

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• Inhibition of NF-kappaB in cancer cells converts inflammation- induced tumor growth mediated by TNFalpha to TRAIL-mediated tumor regression.

  We used an experimental murine cancer metastasis model in which a colon adenocarcinoma cell line generates lung metastases, whose growth is stimulated…

  Authors: Jun-Li Luo, Shin Maeda, Li-Chung Hsu, Hideo Yagita, Michael Karin

  Source: Cancer cell. 2004 Sep

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• IKKbeta is required for prevention of apoptosis mediated by cell-bound but not by circulating TNFalpha.

  IkappaB kinase beta (IKKbeta) is required for NF-kappaB activation and suppression of TNFalpha-mediated liver apoptosis. To investigate how IKKbeta su…

  Authors: Shin Maeda, Lufen Chang, Zhi-Wei Li, Jun-Li Luo, Hyam Leffert, Michael Karin

  Source: Immunity. 2003 Nov

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• The anti-death machinery in IKK/NF-kappaB signaling.

  The most extensively studied function of NF-kappaB is its ability to promote cell survival through induction of target genes, whose products inhibit v…

  Authors: Jun-Li Luo, Hideaki Kamata, Michael Karin

  Source: Journal of clinical immunology. 2005 Nov

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