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SOSS complexes participate in the maintenance of genomic stability.
Proteins that bind to single-stranded DNA (ssDNA) are essential for DNA replication, recombinational repair, and maintenance of genomic stability. Her…
Authors: Jun Huang, Zihua Gong, Gargi Ghosal, Junjie Chen
Source: Molecular cell. 2009 Aug 14
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MERIT40 facilitates BRCA1 localization and DNA damage repair.
The product of breast cancer susceptibility gene 1, BRCA1, plays pivotal roles in the maintenance of genomic integrity. Mounting evidence indicates th…
Authors: Lin Feng, Jun Huang, Junjie Chen
Source: Genes & development. 2009 Mar 15
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RAD18 transmits DNA damage signalling to elicit homologous recombination repair.
To maintain genome stability, cells respond to DNA damage by activating signalling pathways that govern cell-cycle checkpoints and initiate DNA repair…
Authors: Jun Huang, Michael S Y Huen, Hongtae Kim, Charles Chung Yun Leung, J N Mark Glover, Xiaochun Yu, Junjie Chen
Source: Nature cell biology. 2009 May
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Plk1-dependent phosphorylation of FoxM1 regulates a transcriptional programme required for mitotic progression.
Proper control of entry into and progression through mitosis is essential for normal cell proliferation and the maintenance of genome stability. The m…
Authors: Zheng Fu, Liviu Malureanu, Jun Huang, Wei Wang, Hao Li, Jan M van Deursen, Donald J Tindall, Junjie Chen
Source: Nature cell biology. 2008 Sep
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Continuous particle separation in a microfluidic channel via standing surface acoustic waves (SSAW).
This work introduces a method of continuous particle separation through standing surface acoustic wave (SSAW)-induced acoustophoresis in a microfluidi…
Authors: Jinjie Shi, Hua Huang, Zak Stratton, Yiping Huang, Tony Jun Huang
Source: Lab on a chip. 2009 Dec 7
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MicroRNA-101, down-regulated in hepatocellular carcinoma, promotes apoptosis and suppresses tumorigenicity.
Although aberrant microRNA (miRNA) expressions have been observed in different types of cancer, their pathophysiologic role and their relevance to tum…
Authors: Hang Su, Jian-Rong Yang, Teng Xu, Jun Huang, Li Xu, Yunfei Yuan, Shi-Mei Zhuang
Source: Cancer research. 2009 Feb 1
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Glycine exists mainly as monomers, not dimers, in supersaturated aqueous solutions: implications for understanding its crystallization and polymorphism.
Glycine, the simplest amino acid, is described as existing as hydrogen-bonded cyclic dimers in supersaturated aqueous solutions and, as a result, crys…
Authors: Jun Huang, Thomas C Stringfellow, Lian Yu
Source: Journal of the American Chemical Society. 2008 Oct 22
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Effect of molecular chirality on racemate stability: alpha-amino acids with nonpolar R groups.
A racemate of two opposite and resolvable enantiomers is generally assumed to be more stable than the corresponding conglomerate. Demonstrating this s…
Source: Journal of the American Chemical Society. 2006 Feb 15
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Adsorption-desorption induced structural changes of Cu-MOF evidenced by solid state NMR and EPR spectroscopy.
Adsorption-desorption induced structural changes of Cu(bpy)(H(2)O)(2)(BF(4)),(bpy) (bpy = 4,4'-bipyridine) [Cu-MOF] have been evidenced by combined NM…
Authors: Yijiao Jiang, Jun Huang, Besnik Kasumaj, Gunnar Jeschke, Michael Hunger, Tamas Mallat, Alfons Baiker
Source: Journal of the American Chemical Society. 2009 Feb 18
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Insight into the mechanisms of the ethylbenzene disproportionation: transition state shape selectivity on zeolites.
The direct experimental evidence shows that ethylbenzene disproportionation is a transition state shape selective reaction on zeolites: a bimolecular …
Authors: Jun Huang, Yijiao Jiang, V R Reddy Marthala, Michael Hunger
Source: Journal of the American Chemical Society. 2008 Sep 24
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