1 to 10 of 14 literature results

• IL-15 constrains mast cell-dependent antibacterial defenses by suppressing chymase activities.

  Sepsis remains a global clinical problem. By using the mouse cecal ligation and puncture model of sepsis, here we identify an important aspect of mast…

  Authors: Zane Orinska, Marcus Maurer, Farhad Mirghomizadeh, Elena Bulanova, Martin Metz, Natalia Nashkevich, Florian Schiemann, Jan Schulmistrat, Vadim Budagian, Julien Giron-Michel,…

  Source: Nature medicine. 2007 Aug

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• EBV-associated mononucleosis does not induce long-term global deficit in T-cell responsiveness to IL-15.

  It has been reported that infectious mononucleosis (IM)-symptomatic primary Epstein-Barr virus infection produces a global down-regulation of interleu…

  Authors: Julien Giron-Michel, Fanny Menard, Simone Negrini, Aurore Devocelle, Bruno Azzarone, Caroline Besson

  Source: Blood. 2009 May 7

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• Human renal cancer cells express a novel membrane-bound interleukin-15 that induces, in response to the soluble interleukin-15 receptor alpha chain, epithelial-to-mesenchymal transition.

  Although interleukin-15 (IL-15) is a powerful immunomodulatory factor that has been proposed for cancer immunotherapy, its intratumoral expression may…

  Authors: Krystel Khawam, Julien Giron-Michel, Yanhong Gu, Aurélie Perier, Massimo Giuliani, Anne Caignard, Aurore Devocelle, Silvano Ferrini, Marina Fabbi, Bernard Charpentier,…

  Source: Cancer research. 2009 Feb 15

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• Membrane-bound interleukin (IL)-15 on renal tumor cells rescues natural killer cells from IL-2 starvation-induced apoptosis.

  Renal cell carcinoma primary tumors and lung metastases are infiltrated by activated natural killer (NK) cells. Interleukin (IL)-15, a major cytokine …

  Authors: Sebastian Wittnebel, Sylvie Da Rocha, Julien Giron-Michel, Abdelali Jalil, Paule Opolon, Bernard Escudier, Pierre Validire, Krystel Khawam, Salem Chouaib, Bruno Azzarone,…

  Source: Cancer research. 2007 Jun 15

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• Membrane-bound and soluble IL-15/IL-15Ralpha complexes display differential signaling and functions on human hematopoietic progenitors.

  Membrane-bound and soluble interleukin-15 (IL-15)/IL-15 receptor alpha (Ralpha) complexes trigger differential transcription factor activation and fun…

  Authors: Julien Giron-Michel, Massimo Giuliani, Manuela Fogli, Danièle Brouty-Boyé, Silvano Ferrini, Florence Baychelier, Pierre Eid, Caroline Lebousse-Kerdilès, Deniz Durali, Roberto Biassoni,…

  Source: Blood. 2005 Oct 1

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• In human B cells, IL-12 triggers a cascade of molecular events similar to Th1 commitment.

  Two functionally distinct subsets of B cells that produce Th1- and Th2-like patterns of cytokines have recently been identified. Interleukin-12 (IL-12…

  Authors: Deniz Durali, Marie-Ghislaine de Goër de Herve, Julien Giron-Michel, Bruno Azzarone, Jean-François Delfraissy, Yassine Taoufik

  Source: Blood. 2003 Dec 1

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• Differential STAT3, STAT5, and NF-kappaB activation in human hematopoietic progenitors by endogenous interleukin-15: implications in the expression of functional molecules.

  Different forms of interleukin-15 (IL-15) have been identified and shown to elicit different transduction pathways whose impact on hematopoiesis is po…

  Authors: Julien Giron-Michel, Anne Caignard, Manuela Fogli, Daniele Brouty-Boyé, Diane Briard, Marc van Dijk, Raffaella Meazza, Silvano Ferrini, Caroline Lebousse-Kerdilès, Denis Clay,…

  Source: Blood. 2003 Jul 1

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• Leukemic target susceptibility to natural killer cytotoxicity: relationship with BCR-ABL expression.

  Chronic myeloid leukemia is a clonal myeloproliferative expansion of transformed primitive hematopoietic progenitor cells characterized by high-level …

  Authors: Frédéric Baron, Ali G Turhan, Julien Giron-Michel, Bruno Azzarone, Mohamed Bentires-Alj, Vincent Bours, Jean Henri Bourhis, Salem Chouaib, Anne Caignard

  Source: Blood. 2002 Mar 15

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• Lung myofibroblasts as targets of salmeterol and fluticasone propionate: inhibition of alpha-SMA and NF-kappaB.

  Lung myofibroblasts play a major role in the pathophysiology of asthma, contributing not only to tissue remodelling but also to airway inflammation. N…

  Authors: Soria Baouz, Julien Giron-Michel, Bruno Azzarone, Massimo Giuliani, Francesca Cagnoni, Susanna Olsson, Renato Testi, Giulio Gabbiani, G Walter Canonica

  Source: International immunology. 2005 Nov

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• Different levels of control prevent interferon-gamma-inducible HLA-class II expression in human neuroblastoma cells.

  The HLA class II expression is controlled by the transcriptional activator CIITA. The transcription of CIITA is controlled by different promoters, amo…

  Authors: Michela Croce, Alessandro De Ambrosis, Maria V Corrias, Vito Pistoia, Marzia Occhino, Raffaella Meazza, Julien Giron-Michel, Bruno Azzarone, Roberto S Accolla, Silvano Ferrini

  Source: Oncogene. 2003 Oct 30

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