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The cJun N-terminal kinase 1 (JNK1) is implicated in diet-induced obesity. Indeed, germline ablation of the murine Jnk1 gene prevents diet-induced obe…
Authors: Guadalupe Sabio, Julie Cavanagh-Kyros, Tamera Barrett, Dae Young Jung, Hwi Jin Ko, Helena Ong, Caroline Morel, Alfonso Mora, Judith Reilly, Jason K Kim,…
Source: Genes & development. 2010 Feb 1
View Full TextBcl2-modifying factor (Bmf) is a member of the BH3-only group of proapoptotic proteins. To test the role of Bmf in vivo, we constructed mice with a se…
Authors: Anette Hübner, Julie Cavanagh-Kyros, Mercedes Rincon, Richard A Flavell, Roger J Davis
Source: Molecular and cellular biology. 2010 Jan
View Full TextJIP scaffold proteins are implicated in the regulation of protein kinase signal transduction pathways. To test the physiological role of these scaffol…
Authors: Norman J Kennedy, Gilles Martin, Anka G Ehrhardt, Julie Cavanagh-Kyros, Chia-Yi Kuan, Pasko Rakic, Richard A Flavell, Steven N Treistman, Roger J Davis
Source: Genes & development. 2007 Sep 15
View Free Full TextObesity caused by feeding of a high-fat diet (HFD) is associated with an increased activation of c-Jun NH(2)-terminal kinase 1 (JNK1). Activated JNK1 …
Authors: Guadalupe Sabio, Norman J Kennedy, Julie Cavanagh-Kyros, Dae Young Jung, Hwi Jin Ko, Helena Ong, Tamera Barrett, Jason K Kim, Roger J Davis
Source: Molecular and cellular biology. 2010 Jan
View Full TextNonalcoholic steatosis (fatty liver) is a major cause of liver dysfunction that is associated with insulin resistance and metabolic syndrome. The cJun…
Authors: Guadalupe Sabio, Julie Cavanagh-Kyros, Hwi Jin Ko, Dae Young Jung, Susan Gray, John Y Jun, Tamera Barrett, Alfonso Mora, Jason K Kim, Roger J Davis
Source: Cell metabolism. 2009 Dec
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