1 to 10 of 35 literature results

• Fly stem cell research gets infectious.

  To maintain tissue homeostasis, stem cells need to increase their proliferation rate to repair tissue damage caused by stress or infection. In this is…

  Authors: Ryan Conder, Juergen A Knoblich

  Source: Cell. 2009 Jun 26

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• Mechanisms of asymmetric stem cell division.

  Stem cells self-renew but also give rise to daughter cells that are committed to lineage-specific differentiation. To achieve this remarkable task, th…

  Authors: Juergen A Knoblich

  Source: Cell. 2008 Feb 22

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• The TRIM-NHL protein TRIM32 activates microRNAs and prevents self-renewal in mouse neural progenitors.

  In the mouse neocortex, neural progenitor cells generate both differentiating neurons and daughter cells that maintain progenitor fate. Here, we show …

  Authors: Jens C Schwamborn, Eugene Berezikov, Juergen A Knoblich

  Source: Cell. 2009 Mar 6

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• Dividing cellular asymmetry: asymmetric cell division and its implications for stem cells and cancer.

  Cell division is commonly thought to involve the equal distribution of cellular components into the two daughter cells. During many cell divisions, ho…

  Authors: Ralph A Neumüller, Juergen A Knoblich

  Source: Genes & development. 2009 Dec 1

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• Linking cell cycle to asymmetric division: Aurora-A phosphorylates the Par complex to regulate Numb localization.

  Drosophila neural precursor cells divide asymmetrically by segregating the Numb protein into one of the two daughter cells. Numb is uniformly cortical…

  Authors: Frederik Wirtz-Peitz, Takashi Nishimura, Juergen A Knoblich

  Source: Cell. 2008 Oct 3

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• Genome-wide analysis of Notch signalling in Drosophila by transgenic RNAi.

  Genome-wide RNA interference (RNAi) screens have identified near-complete sets of genes involved in cellular processes. However, this methodology has …

  Authors: Jennifer L Mummery-Widmer, Masakazu Yamazaki, Thomas Stoeger, Maria Novatchkova, Sheetal Bhalerao, Doris Chen, Georg Dietzl, Barry J Dickson, Juergen A Knoblich

  Source: Nature. 2009 Apr 23

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• Mei-P26 regulates microRNAs and cell growth in the Drosophila ovarian stem cell lineage.

  Drosophila neuroblasts and ovarian stem cells are well characterized models for stem cell biology. In both cell types, one daughter cell self-renews c…

  Authors: Ralph A Neumüller, Joerg Betschinger, Anja Fischer, Natascha Bushati, Ingrid Poernbacher, Karl Mechtler, Stephen M Cohen, Juergen A Knoblich

  Source: Nature. 2008 Jul 10

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• Asymmetric segregation of the tumor suppressor brat regulates self-renewal in Drosophila neural stem cells.

  How stem cells generate both differentiating and self-renewing daughter cells is unclear. Here, we show that Drosophila larval neuroblasts-stem cell-l…

  Authors: Joerg Betschinger, Karl Mechtler, Juergen A Knoblich

  Source: Cell. 2006 Mar 24

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• Endosome dynamics during development.

  Endocytosis has traditionally been studied in isolated cells. More recently, however, the analysis of protein trafficking in whole organisms has revea…

  Authors: Gregory Emery, Juergen A Knoblich

  Source: Current opinion in cell biology. 2006 Aug

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• Heterotrimeric G proteins: new tricks for an old dog.

  Heterotrimeric G proteins are well known for their function in signal transduction downstream of seven transmembrane receptors. More recently, however…

  Authors: Bernhard Hampoelz, Juergen A Knoblich

  Source: Cell. 2004 Nov 12

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