1 to 9 of 9 literature results

• Antiangiogenic compounds interfere with chemotherapy of brain tumors due to vessel normalization.

  Glioblastomas are highly aggressive primary brain tumors. Curative treatment by surgery and radiotherapy is generally impossible due to the presence o…

  Authors: An Claes, Pieter Wesseling, Judith Jeuken, Cathy Maass, Arend Heerschap, William P J Leenders

  Source: Molecular cancer therapeutics. 2008 Jan

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• RAS/RAF pathway activation in gliomas: the result of copy number gains rather than activating mutations.

  Aberrant RAS/RAF signaling has been reported to be important for many tumor types including gliomas. Activation of the RAS/RAF pathway can result from…

  Authors: Judith Jeuken, Caroline van den Broecke, Sabine Gijsen, Sandra Boots-Sprenger, Pieter Wesseling

  Source: Acta neuropathologica. 2007 Aug

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• No preferential loss of paternal 19q alleles in oligodendroglial tumors.

  Recently, exclusive loss of paternal 19q alleles in six of six oligodendrogliomas has been reported, indicating that parental imprinting plays a role …

  Authors: Christian Hartmann, Wolf Mueller, Ulrike Lass, Florian Stockhammer, Kajetan von Eckardstein, Julian Veelken, Judith Jeuken, Wolfgang Wick, Andreas von Deimling

  Source: Annals of neurology. 2003 Aug

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• Evaluation of the efficiency of chemotherapy in in vivo orthotopic models of human glioma cells with and without 1p19q deletions and in C6 rat orthotopic allografts serving for the evaluation of surgery combined with chemotherapy.

  BACKGROUND: Malignant gliomas of the central nervous system remain associated with dismal prognoses because of their diffuse invasion of the brain par…

  Authors: Fabrice Branle, Florence Lefranc, Isabelle Camby, Judith Jeuken, Anneke Geurts-Moespot, Sandra Sprenger, Fred Sweep, Robert Kiss, Isabelle Salmon

  Source: Cancer. 2002 Aug 1

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• Robust detection of EGFR copy number changes and EGFR variant III: technical aspects and relevance for glioma diagnostics.

  Epidermal growth factor receptor (EGFR) is commonly affected in cancer, generally in the form of an increase in DNA copy number and/or as mutation var…

  Authors: Judith Jeuken, Angelique Sijben, Cristina Alenda, Jos Rijntjes, Marieke Dekkers, Sandra Boots-Sprenger, Roger McLendon, Pieter Wesseling

  Source: Brain pathology (Zurich, Switzerland). 2009 Oct

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• Multiplex ligation-dependent probe amplification: a diagnostic tool for simultaneous identification of different genetic markers in glial tumors.

  Genetic aberrations in tumors are predictive for chemosensitivity and survival. A test is needed that allows simultaneous detection of multiple change…

  Authors: Judith Jeuken, Sandra Cornelissen, Sandra Boots-Sprenger, Sabine Gijsen, Pieter Wesseling

  Source: The Journal of molecular diagnostics : JMD. 2006 Sep

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• Chromosome 1p loss evaluation in anaplastic oligodendrogliomas.

  The chromosome (chr) 1p deletion is a favorable biomarker in oligodendroglial tumors and is even more powerful a marker when combined with chr 19q los…

  Authors: Ahmed Idbaih, Mathilde Kouwenhoven, Judith Jeuken, Catherine Carpentier, Thierry Gorlia, Johan M Kros, Pim French, Johannes L Teepen, Olivier Delattre, Jean-Yves Delattre,…

  Source: Neuropathology : official journal of the Japanese Society of Neuropathology. 2008 Aug

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• Molecular analysis as a tool in the differential diagnosis of VHL disease-related tumors.

  Von Hippel-Lindau (VHL) disease is an autosomal dominant tumor syndrome, in which hemangioblastomas (HBs), clear cell renal cell carcinomas (RCCs), an…

  Authors: Johanna Gijtenbeek, Bram Jacobs, Sandra Boots-Sprenger, Anita Bonne, Jacques Lenders, Benno Küsters, Pieter Wesseling, Judith Jeuken

  Source: Diagnostic molecular pathology : the American journal of surgical pathology, part B. 2005 Jun

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• Distinct chromosomal aberrations in sinonasal mucosal melanoma as detected by comparative genomic hybridization.

  Sinonasal mucosal melanomas are the most frequent mucosal melanomas and arise from melanocytes located in the nasal cavity and the paranasal sinuses. …

  Authors: Marcory van Dijk, Sandra Sprenger, Paul Rombout, Henri Marres, Johannes Kaanders, Judith Jeuken, Dirk Ruiter

  Source: Genes, chromosomes & cancer. 2003 Feb

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