1 to 10 of 96 literature results

• A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1).

  We conducted a three-stage genome-wide association study (GWAS) of breast cancer in 9,770 cases and 10,799 controls in the Cancer Genetic Markers of S…

  Authors: Gilles Thomas, Kevin B Jacobs, Peter Kraft, Meredith Yeager, Sholom Wacholder, David G Cox, Susan E Hankinson, Amy Hutchinson, Zhaoming Wang, Kai Yu,…

  Source: Nature genetics. 2009 May

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• A genome-wide association study identifies a new ovarian cancer susceptibility locus on 9p22.2.

  Epithelial ovarian cancer has a major heritable component, but the known susceptibility genes explain less than half the excess familial risk. We perf…

  Authors: Honglin Song, Susan J Ramus, Jonathan Tyrer, Kelly L Bolton, Aleksandra Gentry-Maharaj, Eva Wozniak, Hoda Anton-Culver, Jenny Chang-Claude, Daniel W Cramer, Richard DiCioccio,…

  Source: Nature genetics. 2009 Sep

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• Multiple ADH genes are associated with upper aerodigestive cancers.

  Alcohol is an important risk factor for upper aerodigestive cancers and is principally metabolized by alcohol dehydrogenase (ADH) enzymes. We have inv…

  Authors: Mia Hashibe, James D McKay, Maria Paula Curado, Jose Carlos Oliveira, Sergio Koifman, Rosalina Koifman, David Zaridze, Oxana Shangina, Victor Wünsch-Filho, Jose Eluf-Neto,…

  Source: Nature genetics. 2008 Jun

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• A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25.

  Lung cancer is the most common cause of cancer death worldwide, with over one million cases annually. To identify genetic factors that modify disease …

  Authors: Rayjean J Hung, James D McKay, Valerie Gaborieau, Paolo Boffetta, Mia Hashibe, David Zaridze, Anush Mukeria, Neonilia Szeszenia-Dabrowska, Jolanta Lissowska, Peter Rudnai,…

  Source: Nature. 2008 Apr 3

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• Lung cancer susceptibility locus at 5p15.33.

  We carried out a genome-wide association study of lung cancer (3,259 cases and 4,159 controls), followed by replication in 2,899 cases and 5,573 contr…

  Authors: James D McKay, Rayjean J Hung, Valerie Gaborieau, Paolo Boffetta, Amelie Chabrier, Graham Byrnes, David Zaridze, Anush Mukeria, Neonilia Szeszenia-Dabrowska, Jolanta Lissowska,…

  Source: Nature genetics. 2008 Dec

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• Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2.

  Genome-wide association studies (GWAS) have identified seven breast cancer susceptibility loci, but these explain only a small fraction of the familia…

  Authors: Shahana Ahmed, Gilles Thomas, Maya Ghoussaini, Catherine S Healey, Manjeet K Humphreys, Radka Platte, Jonathan Morrison, Melanie Maranian, Karen A Pooley, Robert Luben,…

  Source: Nature genetics. 2009 May

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• A functional polymorphism of toll-like receptor 4 gene increases risk of gastric carcinoma and its precursors.

  BACKGROUND AND AIMS: TLR4 is a cell-surface signaling receptor involved in the recognition and host response to Helicobacter pylori. The TLR4+896A>G p…

  Authors: Georgina L Hold, Charles S Rabkin, Wong-Ho Chow, Malcolm G Smith, Marilie D Gammon, Harvey A Risch, Thomas L Vaughan, Kenneth E L McColl, Jolanta Lissowska, Witold Zatonski,…

  Source: Gastroenterology. 2007 Mar

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• Effect of cruciferous vegetables on lung cancer in patients stratified by genetic status: a mendelian randomisation approach.

  Whether consumption of cruciferous vegetables protects against lung cancer is unclear, largely because of potential confounding factors. We therefore …

  Authors: Paul Brennan, Charles C Hsu, Norman Moullan, Neonilia Szeszenia-Dabrowska, Jolanta Lissowska, David Zaridze, Peter Rudnai, Eleonora Fabianova, Dana Mates, Vladimir Bencko,…

  Source: Lancet. 2005 Oct 29-Nov 4

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• Genome-wide association study identifies novel breast cancer susceptibility loci.

  Breast cancer exhibits familial aggregation, consistent with variation in genetic susceptibility to the disease. Known susceptibility genes account fo…

  Authors: Douglas F Easton, Karen A Pooley, Alison M Dunning, Paul D P Pharoah, Deborah Thompson, Dennis G Ballinger, Jeffery P Struewing, Jonathan Morrison, Helen Field, Robert Luben,…

  Source: Nature. 2007 Jun 28

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• A common coding variant in CASP8 is associated with breast cancer risk.

  The Breast Cancer Association Consortium (BCAC) has been established to conduct combined case-control analyses with augmented statistical power to try…

  Authors: Angela Cox, Alison M Dunning, Montserrat Garcia-Closas, Sabapathy Balasubramanian, Malcolm W R Reed, Karen A Pooley, Serena Scollen, Caroline Baynes, Bruce A J Ponder, Stephen Chanock,…

  Source: Nature genetics. 2007 Mar

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