1 to 10 of 11 literature results

• A method for quantifying normal human mammary epithelial stem cells with in vivo regenerative ability.

  Previous studies have demonstrated that normal mouse mammary tissue contains a rare subset of mammary stem cells. We now describe a method for detecti…

  Authors: Peter Eirew, John Stingl, Afshin Raouf, Gulisa Turashvili, Samuel Aparicio, Joanne T Emerman, Connie J Eaves

  Source: Nature medicine. 2008 Dec

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• Purification and unique properties of mammary epithelial stem cells.

  Elucidation of the cellular and molecular mechanisms that maintain mammary epithelial tissue integrity is of broad interest and paramount to the desig…

  Authors: John Stingl, Peter Eirew, Ian Ricketson, Mark Shackleton, François Vaillant, David Choi, Haiyan I Li, Connie J Eaves

  Source: Nature. 2006 Feb 23

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• Generation of a functional mammary gland from a single stem cell.

  The existence of mammary stem cells (MaSCs) has been postulated from evidence that the mammary gland can be regenerated by transplantation of epitheli…

  Authors: Mark Shackleton, François Vaillant, Kaylene J Simpson, John Stingl, Gordon K Smyth, Marie-Liesse Asselin-Labat, Li Wu, Geoffrey J Lindeman, Jane E Visvader

  Source: Nature. 2006 Jan 5

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• Steroid hormone receptor status of mouse mammary stem cells.

  The estrogen receptor alpha (ERalpha), progesterone receptor (PR), and erbB2 (Her2 in humans) are important prognostic markers of human breast cancer,…

  Authors: Marie-Liesse Asselin-Labat, Mark Shackleton, John Stingl, François Vaillant, Natasha C Forrest, Connie J Eaves, Jane E Visvader, Geoffrey J Lindeman

  Source: Journal of the National Cancer Institute. 2006 Jul 19

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• Epithelial progenitors in the normal human mammary gland.

  The human mammary gland is organized developmentally as a hierarchy of progenitor cells that become progressively restricted in their proliferative ab…

  Authors: John Stingl, Afshin Raouf, Joanne T Emerman, Connie J Eaves

  Source: Journal of mammary gland biology and neoplasia. 2005 Jan

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• Molecular heterogeneity of breast carcinomas and the cancer stem cell hypothesis.

  Human breast cancers are heterogeneous, both in their pathology and in their molecular profiles. This suggests the hypothesis that breast cancers can …

  Authors: John Stingl, Carlos Caldas

  Source: Nature reviews. Cancer. 2007 Oct

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• Characterisation of microRNA expression in post-natal mouse mammary gland development.

  BACKGROUND: The differential expression pattern of microRNAs (miRNAs) during mammary gland development might provide insights into their role in regul…

  Authors: Stefanie Avril-Sassen, Leonard D Goldstein, John Stingl, Cherie Blenkiron, John Le Quesne, Inmaculada Spiteri, Konstantina Karagavriilidou, Christine J Watson, Simon Tavaré, Eric A Miska,…

  Source: BMC genomics. 2009

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• Deciphering the mammary epithelial cell hierarchy.

  Clonal assays offer a powerful approach to dissecting the many events involved in the generation and maintenance of complex tissues from an undifferen…

  Authors: John Stingl, Afshin Raouf, Peter Eirew, Connie J Eaves

  Source: Cell cycle (Georgetown, Tex.). 2006 Jul

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• PML depletion disrupts normal mammary gland development and skews the composition of the mammary luminal cell progenitor pool.

  Nuclear domains of promyelocytic leukemia protein (PML) are known to act as signaling nodes in many cellular processes. Although the impact of PML exp…

  Authors: Wenjing Li, Brian J Ferguson, Walid T Khaled, Maxine Tevendale, John Stingl, Valeria Poli, Tina Rich, Paolo Salomoni, Christine J Watson

  Source: Proceedings of the National Academy of Sciences of the United States of America. 2009 Mar 24

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• Enzymatic dissociation and culture of normal human mammary tissue to detect progenitor activity.

  Normal human mammary tissue is composed of a glandular epithelium embedded within a fibrous and fatty stroma. Collagenase and hyaluronidase digestion …

  Authors: John Stingl, Joanne T Emerman, Connie J Eaves

  Source: Methods in molecular biology (Clifton, N.J.). 2005

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