1 to 5 of 5 literature results

• Salt-sensitive blood pressure in mice with increased expression of aldosterone synthase.

  To study the effects of modestly increased expression of aldosterone synthase (AS), we generated mice (AS(hi/hi)) by replacing the 3' untranslated reg…

  Authors: Natalia Makhanova, John Hagaman, Hyung-Suk Kim, Oliver Smithies

  Source: Hypertension. 2008 Jan

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• Anatomical differences and atherosclerosis in apolipoprotein E-deficient mice with 129/SvEv and C57BL/6 genetic backgrounds.

  There are well-known genetic background effects on atherosclerosis susceptibility in mice. To study the basis of these effects, we have generated the …

  Authors: Nobuyo Maeda, Lance Johnson, Shinja Kim, John Hagaman, Morton Friedman, Robert Reddick

  Source: Atherosclerosis. 2007 Nov

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• Adrenomedullin gene expression differences in mice do not affect blood pressure but modulate hypertension-induced pathology in males.

  Adrenomedullin (AM) is a potent vasodilator peptide in plasma at picomolar levels. Polymorphisms in the human AM gene have been associated with geneti…

  Authors: Kathleen Caron, John Hagaman, Toshio Nishikimi, Hyung-Suk Kim, Oliver Smithies

  Source: Proceedings of the National Academy of Sciences of the United States of America. 2007 Feb 27

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• Discordant on/off switching of gene expression in myocytes during cardiac hypertrophy in vivo.

  To determine whether the expression of cardiac genes changes in a graded manner or by on/off switching when cardiac myocytes change genetic programs i…

  Authors: Kumar Pandya, John Cowhig, Joe Brackhan, Hyung Suk Kim, John Hagaman, Mauricio Rojas, Charles W Carter, Lan Mao, Howard A Rockman, Nobuyo Maeda,…

  Source: Proceedings of the National Academy of Sciences of the United States of America. 2008 Sep 2

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• Aortic constriction exacerbates atherosclerosis and induces cardiac dysfunction in mice lacking apolipoprotein E.

  Despite considerable evidence suggesting that hypertension contributes to the development and progression of atherosclerosis, the causative links rema…

  Authors: Jiao-Hui Wu, John Hagaman, Shinja Kim, Robert L Reddick, Nobuyo Maeda

  Source: Arteriosclerosis, thrombosis, and vascular biology. 2002 Mar 1

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