Click on one of these terms to refine your search
1 to 10 of 12 literature results
Notch signaling is an area of great interest in oncology. RO4929097 is a potent and selective inhibitor of gamma-secretase, producing inhibitory activ…
Authors: Leopoldo Luistro, Wei He, Melissa Smith, Kathryn Packman, Maria Vilenchik, Daisy Carvajal, John Roberts, James Cai, Windy Berkofsky-Fessler, Holly Hilton,…
Source: Cancer research. 2009 Oct 1
View Full TextRegions of hypoxia are a hallmark of solid tumors. Tumor cells modulate the regulation of specific genes allowing adaptation and survival in the harsh…
Authors: Alex J Bowers, Sheila Scully, John F Boylan
Source: Oncogene. 2003 May 8
View Full TextDeliberate induction of prophylactic hypercapnic acidosis protects against lung injury after in vivo ischemia-reperfusion and ventilation-induced lung…
Authors: John G Laffey, Dave Honan, Natalie Hopkins, Jean-Marc Hyvelin, John F Boylan, Paul McLoughlin
Source: American journal of respiratory and critical care medicine. 2004 Jan 1
View Full TextThe family of human Nek (NIMA Related Kinase) kinases currently contains 11 members. We have identified Nek8 as a new member of the Nek kinase family.…
Authors: Alex J Bowers, John F Boylan
Source: Gene. 2004 Mar 17
View Full TextAuthors: John F Boylan, Brian P Kavanagh
Source: Anesthesiology. 2008 Oct
View Full TextOBJECTIVE: Deliberate induction of hypercapnic acidosis protects against lung injury after ischemia-reperfusion, endotoxin-induced, and ventilation-in…
Authors: Donall F O'Croinin, Natalie O Hopkins, Michael M Moore, John F Boylan, Paul McLoughlin, John G Laffey
Source: Critical care medicine. 2005 Nov
View Full TextAuthors: John F Boylan, Brian P Kavanagh
Source: Anesthesiology. 2008 Dec
View Full TextIt may be required to ensure patency of the airway in the lateral position in certain circumstances. We performed a prospective randomized clinical tr…
Authors: Conan L McCaul, Donal Harney, Margaret Ryan, Ciaran Moran, Brian P Kavanagh, John F Boylan
Source: Anesthesia and analgesia. 2005 Oct
View Full TextThe identification of indeno[1,2-c]pyrazol-4-ones as inhibitors of cyclin-dependent kinases (CDKs) has led to the discovery of a series of novel and p…
Authors: Eddy W Yue, C Anne Higley, Susan V DiMeo, David J Carini, David A Nugiel, Carrie Benware, Pamela A Benfield, Catherine R Burton, Sarah Cox, Robert H Grafstrom,…
Source: Journal of medicinal chemistry. 2002 Nov 21
View Full TextAuthors: John J Magner, Kieran J Crowley, John F Boylan
Source: Journal of cardiothoracic and vascular anesthesia. 2007 Jun
View Full Text