1 to 10 of 12 literature results

• Preclinical profile of a potent gamma-secretase inhibitor targeting notch signaling with in vivo efficacy and pharmacodynamic properties.

  Notch signaling is an area of great interest in oncology. RO4929097 is a potent and selective inhibitor of gamma-secretase, producing inhibitory activ…

  Authors: Leopoldo Luistro, Wei He, Melissa Smith, Kathryn Packman, Maria Vilenchik, Daisy Carvajal, John Roberts, James Cai, Windy Berkofsky-Fessler, Holly Hilton,…

  Source: Cancer research. 2009 Oct 1

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• SKIP3, a novel Drosophila tribbles ortholog, is overexpressed in human tumors and is regulated by hypoxia.

  Regions of hypoxia are a hallmark of solid tumors. Tumor cells modulate the regulation of specific genes allowing adaptation and survival in the harsh…

  Authors: Alex J Bowers, Sheila Scully, John F Boylan

  Source: Oncogene. 2003 May 8

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• Hypercapnic acidosis attenuates endotoxin-induced acute lung injury.

  Deliberate induction of prophylactic hypercapnic acidosis protects against lung injury after in vivo ischemia-reperfusion and ventilation-induced lung…

  Authors: John G Laffey, Dave Honan, Natalie Hopkins, Jean-Marc Hyvelin, John F Boylan, Paul McLoughlin

  Source: American journal of respiratory and critical care medicine. 2004 Jan 1

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• Nek8, a NIMA family kinase member, is overexpressed in primary human breast tumors.

  The family of human Nek (NIMA Related Kinase) kinases currently contains 11 members. We have identified Nek8 as a new member of the Nek kinase family.…

  Authors: Alex J Bowers, John F Boylan

  Source: Gene. 2004 Mar 17

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• The name of the game: no transfusion (or nontransfusion) by cookbook.

  Authors: John F Boylan, Brian P Kavanagh

  Source: Anesthesiology. 2008 Oct

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• Hypercapnic acidosis does not modulate the severity of bacterial pneumonia-induced lung injury.

  OBJECTIVE: Deliberate induction of hypercapnic acidosis protects against lung injury after ischemia-reperfusion, endotoxin-induced, and ventilation-in…

  Authors: Donall F O'Croinin, Natalie O Hopkins, Michael M Moore, John F Boylan, Paul McLoughlin, John G Laffey

  Source: Critical care medicine. 2005 Nov

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• Emergency airway management: competence versus expertise?

  Authors: John F Boylan, Brian P Kavanagh

  Source: Anesthesiology. 2008 Dec

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• Airway management in the lateral position: a randomized controlled trial.

  It may be required to ensure patency of the airway in the lateral position in certain circumstances. We performed a prospective randomized clinical tr…

  Authors: Conan L McCaul, Donal Harney, Margaret Ryan, Ciaran Moran, Brian P Kavanagh, John F Boylan

  Source: Anesthesia and analgesia. 2005 Oct

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• Synthesis and evaluation of indenopyrazoles as cyclin-dependent kinase inhibitors. 3. Structure activity relationships at C3(1,2).

  The identification of indeno[1,2-c]pyrazol-4-ones as inhibitors of cyclin-dependent kinases (CDKs) has led to the discovery of a series of novel and p…

  Authors: Eddy W Yue, C Anne Higley, Susan V DiMeo, David J Carini, David A Nugiel, Carrie Benware, Pamela A Benfield, Catherine R Burton, Sarah Cox, Robert H Grafstrom,…

  Source: Journal of medicinal chemistry. 2002 Nov 21

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• Fatal fibrinolysis during orthotopic liver transplantation in patients receiving solvent/detergent-treated plasma (Octaplas).

  Authors: John J Magner, Kieran J Crowley, John F Boylan

  Source: Journal of cardiothoracic and vascular anesthesia. 2007 Jun

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