1 to 10 of 243 literature results

• Sunburned skin activates inflammasomes.

  Ultraviolet (UV) irradiation injures the epidermis, resulting in sunburn and inflammation. UV-irradiated keratinocytes secrete interleukin-1beta throu…

  Authors: Benjamin Faustin, John C Reed

  Source: Trends in cell biology. 2008 Jan

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• Daxx represses RelB target promoters via DNA methyltransferase recruitment and DNA hypermethylation.

  The apoptosis-modulating protein Daxx functions as a transcriptional repressor that binds to and suppresses the activity of nuclear factor-kappaB memb…

  Authors: Lorena A Puto, John C Reed

  Source: Genes & development. 2008 Apr 15

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• Bcl-2-family proteins and hematologic malignancies: history and future prospects.

  BCL-2 was the first antideath gene discovered, a milestone that effectively launched a new era in cell death research. Since its discovery more than 2…

  Authors: John C Reed

  Source: Blood. 2008 Apr 1

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• Birc2 (cIap1) regulates endothelial cell integrity and blood vessel homeostasis.

  Integrity of the blood vessel wall is essential for vascular homeostasis and organ function. A dynamic balance between endothelial cell survival and a…

  Authors: Massimo M Santoro, Temesgen Samuel, Tracy Mitchell, John C Reed, Didier Y R Stainier

  Source: Nature genetics. 2007 Nov

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• The Patched dependence receptor triggers apoptosis through a DRAL-caspase-9 complex.

  Sonic hedgehog (Shh) and its main receptor, Patched (Ptc), are implicated in both neural development and tumorigenesis. Besides its classic morphogeni…

  Authors: Frédéric Mille, Chantal Thibert, Joanna Fombonne, Nicolas Rama, Catherine Guix, Hideki Hayashi, Véronique Corset, John C Reed, Patrick Mehlen

  Source: Nature cell biology. 2009 Jun

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• Inhibition of tumor growth using salmonella expressing Fas ligand.

  Intravenous administration of bacteria leads to their accumulation in tumors and to sporadic tumor regression. We therefore explored the hypothesis th…

  Authors: Markus Loeffler, Gaelle Le'Negrate, Maryla Krajewska, John C Reed

  Source: Journal of the National Cancer Institute. 2008 Aug 6

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• BAX inhibitor-1 is a negative regulator of the ER stress sensor IRE1alpha.

  Adaptation to endoplasmic reticulum (ER) stress depends on the activation of an integrated signal transduction pathway known as the unfolded protein r…

  Authors: Fernanda Lisbona, Diego Rojas-Rivera, Peter Thielen, Sebastian Zamorano, Derrick Todd, Fabio Martinon, Alvaro Glavic, Christina Kress, Jonathan H Lin, Peter Walter,…

  Source: Molecular cell. 2009 Mar 27

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• Simultaneous activation of p53 and inhibition of XIAP enhance the activation of apoptosis signaling pathways in AML.

  Activation of p53 by murine double minute (MDM2) antagonist nutlin-3a or inhibition of X-linked inhibitor of apoptosis (XIAP) induces apoptosis in acu…

  Authors: Bing Z Carter, Duncan H Mak, Wendy D Schober, Erich Koller, Clemencia Pinilla, Lyubomir T Vassilev, John C Reed, Michael Andreeff

  Source: Blood. 2010 Jan 14

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• Bcl-2 and Bcl-XL regulate proinflammatory caspase-1 activation by interaction with NALP1.

  Caspases are intracellular proteases that cleave substrates involved in apoptosis or inflammation. In C. elegans, a paradigm for caspase regulation ex…

  Authors: Jean-Marie Bruey, Nathalie Bruey-Sedano, Frederic Luciano, Dayong Zhai, Ruchi Balpai, Chunyan Xu, Christina L Kress, Beatrice Bailly-Maitre, Xiaoqing Li, Andrei Osterman,…

  Source: Cell. 2007 Apr 6

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• Lymphocyte-specific TRAF3 transgenic mice have enhanced humoral responses and develop plasmacytosis, autoimmunity, inflammation, and cancer.

  Tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3) regulates both innate and adaptive immunity by modulating signaling by Toll-like rece…

  Authors: Juan M Zapata, David Llobet, Maryla Krajewska, Sophie Lefebvre, Christina L Kress, John C Reed

  Source: Blood. 2009 May 7

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