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Certain disease states are characterized by disturbances in production, accumulation or clearance of protein. In Alzheimer disease, accumulation of am…
Authors: Randall J Bateman, Ling Y Munsell, John C Morris, Robert Swarm, Kevin E Yarasheski, David M Holtzman
Source: Nature medicine. 2006 Jul
View Full TextInterleukin-15 (IL-15) stimulates the diffrentiation and proliferation of T, B, and natural killer cells; enhances CD8(+) cytolytic T-ceII activity; h…
Authors: Jason C Steel, Charmaine A Ramlogan, Ping Yu, Yoshio Sakai, Guido Forni, Thomas A Waldmann, John C Morris
Source: Cancer research. 2010 Feb 1
View Full TextOBJECTIVE: To examine interactions of apolipoprotein E (APOE) genotype with age and with in vivo measures of preclinical Alzheimer disease (AD) in cog…
Authors: John C Morris, Catherine M Roe, Chengjie Xiong, Anne M Fagan, Alison M Goate, David M Holtzman, Mark A Mintun
Source: Annals of neurology. 2010 Jan
View Full TextBACKGROUND: Important functional connections within the default mode network (DMN) are disrupted in Alzheimer's disease (AD), likely from amyloid-beta…
Authors: Yvette I Sheline, Marcus E Raichle, Abraham Z Snyder, John C Morris, Denise Head, Suzhi Wang, Mark A Mintun
Source: Biological psychiatry. 2010 Mar 15
View Full TextFrontotemporal lobar degeneration (FTLD) is the second most common cause of presenile dementia. The predominant neuropathology is FTLD with TAR DNA-bi…
Authors: Vivianna M Van Deerlin, Patrick M A Sleiman, Maria Martinez-Lage, Alice Chen-Plotkin, Li-San Wang, Neill R Graff-Radford, Dennis W Dickson, Rosa Rademakers, Bradley F Boeve, Murray Grossman,…
Source: Nature genetics. 2010 Mar
View Full TextBACKGROUND: To date, all known Alzheimer's disease genes influence amyloid beta (Abeta). Imaging of Abeta deposition in the human brain using Pittsbur…
Authors: Anthony L Hinrichs, Mark A Mintun, Denise Head, Anne M Fagan, David M Holtzman, John C Morris, Alison M Goate
Source: Biological psychiatry. 2010 Mar 15
View Full TextOBJECTIVE: For therapies for Alzheimer's disease (AD) to have the greatest impact, it will likely be necessary to treat individuals in the "preclinica…
Authors: Anne M Fagan, Denise Head, Aarti R Shah, Daniel Marcus, Mark Mintun, John C Morris, David M Holtzman
Source: Annals of neurology. 2009 Feb
View Full TextMonoclonal antibodies are among the most rapidly expanding class of therapeutics for cancer treatment. Monoclonal antibodies targeting non-Hodgkin's l…
Authors: Thomas A Waldmann, John C Morris
Source: Advances in immunology. 2006
View Full TextOBJECTIVE: We previously used exploratory analyses across the entire cortex to determine that mild Alzheimer disease (AD) is reliably associated with …
Authors: Akram Bakkour, John C Morris, Bradford C Dickerson
Source: Neurology. 2009 Mar 24
View Full TextPersistent elevation of TSH levels in patients under treatment for hypothyroidism is a relatively common clinical problem in endocrinology practice. T…
Authors: John C Morris
Source: Clinical endocrinology. 2009 May
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