1 to 10 of 236 literature results

• Human amyloid-beta synthesis and clearance rates as measured in cerebrospinal fluid in vivo.

  Certain disease states are characterized by disturbances in production, accumulation or clearance of protein. In Alzheimer disease, accumulation of am…

  Authors: Randall J Bateman, Ling Y Munsell, John C Morris, Robert Swarm, Kevin E Yarasheski, David M Holtzman

  Source: Nature medicine. 2006 Jul

  View Full Text

• Interleukin-15 and its receptor augment dendritic cell vaccination against the neu oncogene through the induction of antibodies partially independent of CD4 help.

  Interleukin-15 (IL-15) stimulates the diffrentiation and proliferation of T, B, and natural killer cells; enhances CD8(+) cytolytic T-ceII activity; h…

  Authors: Jason C Steel, Charmaine A Ramlogan, Ping Yu, Yoshio Sakai, Guido Forni, Thomas A Waldmann, John C Morris

  Source: Cancer research. 2010 Feb 1

  View Full Text

• APOE predicts amyloid-beta but not tau Alzheimer pathology in cognitively normal aging.

  OBJECTIVE: To examine interactions of apolipoprotein E (APOE) genotype with age and with in vivo measures of preclinical Alzheimer disease (AD) in cog…

  Authors: John C Morris, Catherine M Roe, Chengjie Xiong, Anne M Fagan, Alison M Goate, David M Holtzman, Mark A Mintun

  Source: Annals of neurology. 2010 Jan

  View Full Text

• Amyloid plaques disrupt resting state default mode network connectivity in cognitively normal elderly.

  BACKGROUND: Important functional connections within the default mode network (DMN) are disrupted in Alzheimer's disease (AD), likely from amyloid-beta…

  Authors: Yvette I Sheline, Marcus E Raichle, Abraham Z Snyder, John C Morris, Denise Head, Suzhi Wang, Mark A Mintun

  Source: Biological psychiatry. 2010 Mar 15

  View Full Text

• Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions.

  Frontotemporal lobar degeneration (FTLD) is the second most common cause of presenile dementia. The predominant neuropathology is FTLD with TAR DNA-bi…

  Authors: Vivianna M Van Deerlin, Patrick M A Sleiman, Maria Martinez-Lage, Alice Chen-Plotkin, Li-San Wang, Neill R Graff-Radford, Dennis W Dickson, Rosa Rademakers, Bradley F Boeve, Murray Grossman,…

  Source: Nature genetics. 2010 Mar

  View Full Text

• Cortical binding of pittsburgh compound B, an endophenotype for genetic studies of Alzheimer's disease.

  BACKGROUND: To date, all known Alzheimer's disease genes influence amyloid beta (Abeta). Imaging of Abeta deposition in the human brain using Pittsbur…

  Authors: Anthony L Hinrichs, Mark A Mintun, Denise Head, Anne M Fagan, David M Holtzman, John C Morris, Alison M Goate

  Source: Biological psychiatry. 2010 Mar 15

  View Full Text

• Decreased cerebrospinal fluid Abeta(42) correlates with brain atrophy in cognitively normal elderly.

  OBJECTIVE: For therapies for Alzheimer's disease (AD) to have the greatest impact, it will likely be necessary to treat individuals in the "preclinica…

  Authors: Anne M Fagan, Denise Head, Aarti R Shah, Daniel Marcus, Mark Mintun, John C Morris, David M Holtzman

  Source: Annals of neurology. 2009 Feb

  View Full Text

• Development of antibodies and chimeric molecules for cancer immunotherapy.

  Monoclonal antibodies are among the most rapidly expanding class of therapeutics for cancer treatment. Monoclonal antibodies targeting non-Hodgkin's l…

  Authors: Thomas A Waldmann, John C Morris

  Source: Advances in immunology. 2006

  View Full Text

• The cortical signature of prodromal AD: regional thinning predicts mild AD dementia.

  OBJECTIVE: We previously used exploratory analyses across the entire cortex to determine that mild Alzheimer disease (AD) is reliably associated with …

  Authors: Akram Bakkour, John C Morris, Bradford C Dickerson

  Source: Neurology. 2009 Mar 24

  View Full Text

• How do you approach the problem of TSH elevation in a patient on high-dose thyroid hormone replacement?

  Persistent elevation of TSH levels in patients under treatment for hypothyroidism is a relatively common clinical problem in endocrinology practice. T…

  Authors: John C Morris

  Source: Clinical endocrinology. 2009 May

  View Full Text