10 literature results

• Regulatory T cells and the PD-L1/PD-1 pathway mediate immune suppression in malignant human brain tumors.

  The brain is a specialized immune site representing a unique tumor microenvironment. The availability of fresh brain tumor material for ex vivo analys…

  Authors: Joannes F M Jacobs, Albert J Idema, Kalijn F Bol, Stefan Nierkens, Oliver M Grauer, Pieter Wesseling, J André Grotenhuis, Peter M Hoogerbrugge, I Jolanda M de Vries, Gosse J Adema

  Source: Neuro-oncology. 2009 Aug

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• Toll-like receptor signalling on Tregs: to suppress or not to suppress?

  To balance self-tolerance and immunity against pathogens or tumours, the immune system depends on both activation mechanisms and down-regulatory mecha…

  Authors: Wendy W C van Maren, Joannes F M Jacobs, I Jolanda M de Vries, Stefan Nierkens, Gosse J Adema

  Source: Immunology. 2008 Aug

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• Regulation of MYCN expression in human neuroblastoma cells.

  BACKGROUND: Amplification of the MYCN gene in neuroblastoma (NB) is associated with a poor prognosis. However, MYCN-amplification does not automatical…

  Authors: Joannes F M Jacobs, Hans van Bokhoven, Frank N van Leeuwen, Christina A Hulsbergen-van de Kaa, I Jolanda M de Vries, Gosse J Adema, Peter M Hoogerbrugge, Arjan P M de Brouwer

  Source: BMC cancer. 2009

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• Selective cancer-germline gene expression in pediatric brain tumors.

  Cancer-germline genes (CGGs) code for immunogenic antigens that are present in various human tumors and can be targeted by immunotherapy. Their expres…

  Authors: Joannes F M Jacobs, Oliver M Grauer, Francis Brasseur, Peter M Hoogerbrugge, Pieter Wesseling, Corrie E Gidding, Mandy W M M van de Rakt, Carl G Figdor, Pierre G Coulie, I Jolanda M de Vries,…

  Source: Journal of neuro-oncology. 2008 Jul

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• Vaccine-specific local T cell reactivity in immunotherapy-associated vitiligo in melanoma patients.

  The occurrence of vitiligo in patients with melanoma is especially reported for patients undergoing immunotherapy. While vitiligo in these patients is…

  Authors: Joannes F M Jacobs, Erik H J G Aarntzen, Lenny A G Sibelt, Willeke A Blokx, Anna C I Boullart, Marie-Jeanne Gerritsen, Peter M Hoogerbrugge, Carl G Figdor, Gosse J Adema, Cornelis J A Punt,…

  Source: Cancer immunology, immunotherapy : CII. 2009 Jan

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• Elimination of regulatory T cells is essential for an effective vaccination with tumor lysate-pulsed dendritic cells in a murine glioma model.

  Both melanoma and glioma cells are of neuroectodermal origin and share common tumor associated antigens. In this article, we report that the melanocyt…

  Authors: Oliver M Grauer, Roger P M Sutmuller, Wendy van Maren, Joannes F M Jacobs, Erik Bennink, Liza W J Toonen, Stefan Nierkens, Gosse J Adema

  Source: International journal of cancer. Journal international du cancer. 2008 Apr 15

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• Phenotypic and functional characterization of mature dendritic cells from pediatric cancer patients.

  BACKGROUND: Dendritic cells (DCs) are the most potent antigen-presenting cells of the immune system. Clinical trials have demonstrated that mature DCs…

  Authors: Joannes F M Jacobs, Peter M Hoogerbrugge, Mandy W M M van de Rakt, Erik H J G Aarntzen, Carl G Figdor, Gosse J Adema, I Jolanda M de Vries

  Source: Pediatric blood & cancer. 2007 Dec

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• Limited amounts of dendritic cells migrate into the T-cell area of lymph nodes but have high immune activating potential in melanoma patients.

  PURPOSE: The success of immunotherapy with dendritic cells (DC) to treat cancer is dependent on effective migration to the lymph nodes and subsequent …

  Authors: Pauline Verdijk, Erik H J G Aarntzen, W Joost Lesterhuis, A C Inge Boullart, Ellemieke Kok, Michelle M van Rossum, Simon Strijk, Femke Eijckeler, Johannes J Bonenkamp, Joannes F M Jacobs,…

  Source: Clinical cancer research : an official journal of the American Association for Cancer Research. 2009 Apr 1

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• Maturation of monocyte-derived dendritic cells with Toll-like receptor 3 and 7/8 ligands combined with prostaglandin E2 results in high interleukin-12 production and cell migration.

  Dendritic cells (DC) are professional antigen-presenting cells of the immune system that play a key role in regulating T cell-based immunity. In vivo,…

  Authors: A C Inge Boullart, Erik H J G Aarntzen, Pauline Verdijk, Joannes F M Jacobs, Danita H Schuurhuis, Daniel Benitez-Ribas, Gerty Schreibelt, Mandy W M M van de Rakt, Nicole M Scharenborg, Annemiek de Boer,…

  Source: Cancer immunology, immunotherapy : CII. 2008 Nov

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• Cancer-germline gene expression in pediatric solid tumors using quantitative real-time PCR.

  Cancer-germline genes (CGGs) code for immunogenic antigens that are present on various human tumors but not on normal tissues. The importance of CGGs …

  Authors: Joannes F M Jacobs, Francis Brasseur, Christina A Hulsbergen-van de Kaa, Mandy W M M van de Rakt, Carl G Figdor, Gosse J Adema, Peter M Hoogerbrugge, Pierre G Coulie, I Jolanda M de Vries

  Source: International journal of cancer. Journal international du cancer. 2007 Jan 1

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