1 to 10 of 15 literature results

• Signaling and epigenetic regulation of pituitary development.

  The developing pituitary gland provides an instructive model system for elucidating the molecular mechanisms by which distinct cell types arise from a…

  Authors: Xiaoyan Zhu, Jianxun Wang, Bong-Gun Ju, Michael G Rosenfeld

  Source: Current opinion in cell biology. 2007 Dec

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• Histone methylation-dependent mechanisms impose ligand dependency for gene activation by nuclear receptors.

  Nuclear receptors undergo ligand-dependent conformational changes that are required for corepressor-coactivator exchange, but whether there is an actu…

  Authors: Ivan Garcia-Bassets, Young-Soo Kwon, Francesca Telese, Gratien G Prefontaine, Kasey R Hutt, Christine S Cheng, Bong-Gun Ju, Kenneth A Ohgi, Jianxun Wang, Laure Escoubet-Lozach,…

  Source: Cell. 2007 Feb 9

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• Opposing LSD1 complexes function in developmental gene activation and repression programmes.

  Precise control of transcriptional programmes underlying metazoan development is modulated by enzymatically active co-regulatory complexes, coupled wi…

  Authors: Jianxun Wang, Kathleen Scully, Xiaoyan Zhu, Ling Cai, Jie Zhang, Gratien G Prefontaine, Anna Krones, Kenneth A Ohgi, Ping Zhu, Ivan Garcia-Bassets,…

  Source: Nature. 2007 Apr 19

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• Histone H2A monoubiquitination represses transcription by inhibiting RNA polymerase II transcriptional elongation.

  Solving the biological roles of covalent histone modifications, including monoubiquitination of histone H2A, and the molecular mechanisms by which the…

  Authors: Wenlai Zhou, Ping Zhu, Jianxun Wang, Gabriel Pascual, Kenneth A Ohgi, Jean Lozach, Christopher K Glass, Michael G Rosenfeld

  Source: Molecular cell. 2008 Jan 18

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• A histone H2A deubiquitinase complex coordinating histone acetylation and H1 dissociation in transcriptional regulation.

  Deciphering the epigenetic "code" remains a central issue in transcriptional regulation. Here, we report the identification of a JAMM/MPN(+) domain-co…

  Authors: Ping Zhu, Wenlai Zhou, Jianxun Wang, Janusz Puc, Kenneth A Ohgi, Hediye Erdjument-Bromage, Paul Tempst, Christopher K Glass, Michael G Rosenfeld

  Source: Molecular cell. 2007 Aug 17

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• Cardioprotection during the final stage of the late phase of ischemic preconditioning is mediated by neuronal NO synthase in concert with cyclooxygenase-2.

  The infarct-sparing effect of the late phase of ischemic preconditioning (late PC) lasts for 72 hours. Upregulation of both cyclooxygenase-2 (COX-2) a…

  Authors: Yang Wang, Eitaro Kodani, Jianxun Wang, Shelley X Zhang, Hitoshi Takano, Xian-Liang Tang, Roberto Bolli

  Source: Circulation research. 2004 Jul 9

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• Inhibition of superoxide generation and associated nitrosative damage is involved in metallothionein prevention of diabetic cardiomyopathy.

  The mechanisms of metallothionein prevention of diabetic cardiomyopathy are largely unknown. The present study was performed to test whether inhibitio…

  Authors: Lu Cai, Jianxun Wang, Yan Li, Xuihua Sun, Lipeng Wang, Zhanxiang Zhou, Y James Kang

  Source: Diabetes. 2005 Jun

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• Cardiac metallothionein induction plays the major role in the prevention of diabetic cardiomyopathy by zinc supplementation.

  BACKGROUND: Our previous studies showed that transgenic mice that overexpress cardiac-specific metallothionein (MT) are highly resistant to diabetes-i…

  Authors: Jianxun Wang, Ye Song, Laila Elsherif, Zhenyuan Song, Guihua Zhou, Sumanth D Prabhu, Jack T Saari, Lu Cai

  Source: Circulation. 2006 Jan 31

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• Ischemic preconditioning upregulates inducible nitric oxide synthase in cardiac myocyte.

  Recent evidence has shown that the cardioprotection afforded by the late phase of ischemic preconditioning (PC) is mediated by upregulation of inducib…

  Authors: Yang Wang, Yiru Guo, Shelley X Zhang, Wen-Jian Wu, Jianxun Wang, Weike Bao, Roberto Bolli

  Source: Journal of molecular and cellular cardiology. 2002 Jan

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• Cardiac phosphatase-deficient 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase increases glycolysis, hypertrophy, and myocyte resistance to hypoxia.

  During ischemia and heart failure, there is an increase in cardiac glycolysis. To understand if this is beneficial or detrimental to the heart, we chr…

  Authors: Qianwen Wang, Rajakumar V Donthi, Jianxun Wang, Alex J Lange, Lewis J Watson, Steven P Jones, Paul N Epstein

  Source: American journal of physiology. Heart and circulatory physiology. 2008 Jun

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