1 to 10 of 82 literature results

• An essential function of the SRC-3 coactivator in suppression of cytokine mRNA translation and inflammatory response.

  Steroid receptor coactivator-3 (SRC-3) is a transcriptional coactivator for nuclear receptors and other transcription factors. Although multiple physi…

  Authors: Chundong Yu, Brian York, Shu Wang, Qin Feng, Jianming Xu, Bert W O'Malley

  Source: Molecular cell. 2007 Mar 9

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• The steroid receptor coactivator-1 regulates twist expression and promotes breast cancer metastasis.

  In breast cancer, steroid receptor coactivator-1 (SRC-1) expression positively correlates with HER2 expression and poor prognosis. In mouse mammary tu…

  Authors: Li Qin, Zhaoliang Liu, Hongwu Chen, Jianming Xu

  Source: Cancer research. 2009 May 1

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• Tissue- and nuclear receptor-specific function of the C-terminal LXXLL motif of coactivator NCoA6/AIB3 in mice.

  Although the LXXLL motif of nuclear receptor (NR) coactivators is essential for interaction with NRs, its role has not been assessed in unbiased anima…

  Authors: Qingtian Li, Mei-Jin Chu, Jianming Xu

  Source: Molecular and cellular biology. 2007 Dec

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• Steroid receptor coactivator 3 maintains circulating insulin-like growth factor I (IGF-I) by controlling IGF-binding protein 3 expression.

  Steroid receptor coactivator 3 (SRC-3/AIB1/ACTR/NCoA-3) is a transcriptional coactivator for nuclear receptors including vitamin D receptor (VDR). Gro…

  Authors: Lan Liao, Xian Chen, Shu Wang, Albert F Parlow, Jianming Xu

  Source: Molecular and cellular biology. 2008 Apr

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• The nuclear receptor coactivator amplified in breast cancer-1 is required for Neu (ErbB2/HER2) activation, signaling, and mammary tumorigenesis in mice.

  Overexpression of the oncogene amplified in breast cancer 1 (AIB1)/steroid receptor coactivator-3 (SRC-3) induces mammary tumorigenesis in mice. In br…

  Authors: Mark P Fereshteh, Maddalena T Tilli, Sung Eun Kim, Jianming Xu, Bert W O'Malley, Anton Wellstein, Priscilla A Furth, Anna T Riegel

  Source: Cancer research. 2008 May 15

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• Genetic screening reveals an essential role of p27kip1 in restriction of breast cancer progression.

  The genetic changes and mechanisms underlying the progression of estrogen-dependent breast cancers to estrogen-independent, antiestrogen-resistant, an…

  Authors: Yuhui Yuan, Li Qin, Dan Liu, Ray-Chang Wu, Paola Mussi, Suoling Zhou, Zhou Songyang, Jianming Xu

  Source: Cancer research. 2007 Sep 1

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• Genetic ablation of the amplified-in-breast cancer 1 inhibits spontaneous prostate cancer progression in mice.

  Although the amplified-in-breast cancer 1 (AIB1; SRC-3, ACTR, or NCoA3) was defined as a coactivator for androgen receptor (AR) by in vitro studies, i…

  Authors: Arthur C-K Chung, Suoling Zhou, Lan Liao, Jean Ching-Yi Tien, Norman M Greenberg, Jianming Xu

  Source: Cancer research. 2007 Jun 15

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• The AIB1 oncogene promotes breast cancer metastasis by activation of PEA3-mediated matrix metalloproteinase 2 (MMP2) and MMP9 expression.

  Amplified-in-breast cancer 1 (AIB1) is an overexpressed transcriptional coactivator in breast cancer. Although overproduced AIB1 is oncogenic, its rol…

  Authors: Li Qin, Lan Liao, Aisling Redmond, Leonie Young, Yuhui Yuan, Hongwu Chen, Bert W O'Malley, Jianming Xu

  Source: Molecular and cellular biology. 2008 Oct

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• Tyrosine phosphorylation of the nuclear receptor coactivator AIB1/SRC-3 is enhanced by Abl kinase and is required for its activity in cancer cells.

  Overexpression and activation of the steroid receptor coactivator amplified in breast cancer 1 (AIB1)/steroid receptor coactivator-3 (SRC-3) have been…

  Authors: Annabell S Oh, John T Lahusen, Christopher D Chien, Mark P Fereshteh, Xiaolong Zhang, Sivanesan Dakshanamurthy, Jianming Xu, Benjamin L Kagan, Anton Wellstein, Anna T Riegel

  Source: Molecular and cellular biology. 2008 Nov

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• Altered mammary gland development in the p53+/m mouse, a model of accelerated aging.

  The tumor suppressor p53 is important for inhibiting the development of breast carcinomas. However, little is known about the effects of increased p53…

  Authors: Catherine E Gatza, Melissa Dumble, Frances Kittrell, David G Edwards, Robert K Dearth, Adrian V Lee, Jianming Xu, Daniel Medina, Lawrence A Donehower

  Source: Developmental biology. 2008 Jan 1

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