1 to 10 of 81 literature results

• IKKepsilon: a bridge between obesity and inflammation.

  Obesity leads to tissue inflammation and insulin resistance, which are features of metabolic diseases such as type 2 diabetes. Chiang et al. (2009) no…

  Authors: Jerrold M Olefsky

  Source: Cell. 2009 Sep 4

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• Fat talks, liver and muscle listen.

  Fat metabolism and glucose homeostasis are processes that are highly interconnected. Cao et al. (2008) now take this concept a step further by identif…

  Authors: Jerrold M Olefsky

  Source: Cell. 2008 Sep 19

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• Regulation of receptor tyrosine kinase signaling by GRKs and beta-arrestins.

  Receptor tyrosine kinases (RTKs) are a unique family of cell surface receptors, each containing a common intracellular domain that has tyrosine kinase…

  Authors: Christopher J Hupfeld, Jerrold M Olefsky

  Source: Annual review of physiology. 2007

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• Phosphoinositide signalling links O-GlcNAc transferase to insulin resistance.

  Glucose flux through the hexosamine biosynthetic pathway leads to the post-translational modification of cytoplasmic and nuclear proteins by O-linked …

  Authors: Xiaoyong Yang, Pat P Ongusaha, Philip D Miles, Joyce C Havstad, Fengxue Zhang, W Venus So, Jeffrey E Kudlow, Robert H Michell, Jerrold M Olefsky, Seth J Field,…

  Source: Nature. 2008 Feb 21

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• Bone marrow-specific Cap gene deletion protects against high-fat diet-induced insulin resistance.

  Cbl-associated protein (Cap) is a member of a phosphatidylinositol 3-kinase-independent pathway for insulin-stimulated translocation of the glucose tr…

  Authors: Lisa A Lesniewski, Sarah E Hosch, Jaap G Neels, Carl de Luca, Mohammad Pashmforoush, Carey N Lumeng, Shian-Huey Chiang, Miriam Scadeng, Alan R Saltiel, Jerrold M Olefsky

  Source: Nature medicine. 2007 Apr

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• Insulin disrupts beta-adrenergic signalling to protein kinase A in adipocytes.

  Hormones mobilize intracellular second messengers and initiate signalling cascades involving protein kinases and phosphatases, which are often spatial…

  Authors: Jin Zhang, Christopher J Hupfeld, Susan S Taylor, Jerrold M Olefsky, Roger Y Tsien

  Source: Nature. 2005 Sep 22

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• Deletion of Gab1 in the liver leads to enhanced glucose tolerance and improved hepatic insulin action.

  Insulin receptor substrate-1 (IRS-1) and IRS-2 are known to transduce and amplify signals emanating from the insulin receptor. Here we show that Grb2-…

  Authors: Emilie A Bard-Chapeau, Andrea L Hevener, Shinong Long, Eric E Zhang, Jerrold M Olefsky, Gen-Sheng Feng

  Source: Nature medicine. 2005 May

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• Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes.

  Calorie restriction extends lifespan and produces a metabolic profile desirable for treating diseases of ageing such as type 2 diabetes. SIRT1, an NAD…

  Authors: Jill C Milne, Philip D Lambert, Simon Schenk, David P Carney, Jesse J Smith, David J Gagne, Lei Jin, Olivier Boss, Robert B Perni, Chi B Vu,…

  Source: Nature. 2007 Nov 29

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• Stressed out about obesity and insulin resistance.

  Authors: Carl de Luca, Jerrold M Olefsky

  Source: Nature medicine. 2006 Jan

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• FoxO1 haploinsufficiency protects against high-fat diet-induced insulin resistance with enhanced peroxisome proliferator-activated receptor gamma activation in adipose tissue.

  OBJECTIVE: Forkhead box O (FoxO) transcription factors represent evolutionarily conserved targets of insulin signaling, regulating metabolism and cell…

  Authors: Jane J Kim, Pingping Li, Jessica Huntley, Jeffrey P Chang, Karen C Arden, Jerrold M Olefsky

  Source: Diabetes. 2009 Jun

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