1 to 10 of 38 literature results

• Norrin, frizzled-4, and Lrp5 signaling in endothelial cells controls a genetic program for retinal vascularization.

  Disorders of vascular structure and function play a central role in a wide variety of CNS diseases. Mutations in the Frizzled-4 (Fz4) receptor, Lrp5 c…

  Authors: Xin Ye, Yanshu Wang, Hugh Cahill, Minzhong Yu, Tudor C Badea, Philip M Smallwood, Neal S Peachey, Jeremy Nathans

  Source: Cell. 2009 Oct 16

  View Full Text

• Estrogen-related receptor beta/NR3B2 controls epithelial cell fate and endolymph production by the stria vascularis.

  In the mammalian inner ear, endolymph is produced and resorbed by a complex series of epithelia. We show here that estrogen-related receptor beta (ERR…

  Authors: Jichao Chen, Jeremy Nathans

  Source: Developmental cell. 2007 Sep

  View Full Text

• Distinct roles of transcription factors brn3a and brn3b in controlling the development, morphology, and function of retinal ganglion cells.

  Transcriptional regulatory networks that control the morphologic and functional diversity of mammalian neurons are still largely undefined. Here we di…

  Authors: Tudor C Badea, Hugh Cahill, Jen Ecker, Samer Hattar, Jeremy Nathans

  Source: Neuron. 2009 Mar 26

  View Free Full Text

• Effects of L1 retrotransposon insertion on transcript processing, localization and accumulation: lessons from the retinal degeneration 7 mouse and implications for the genomic ecology of L1 elements.

  The retinal degeneration 7 (rd7) mouse is a naturally occurring model of enhanced S-cone syndrome, Goldman-Favre syndrome and clumped pigmentary retin…

  Authors: Jichao Chen, Amir Rattner, Jeremy Nathans

  Source: Human molecular genetics. 2006 Jul 1

  View Full Text

• Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair.

  Incomplete retinal vascularization occurs in both Norrie disease and familial exudative vitreoretinopathy (FEVR). Norrin, the protein product of the N…

  Authors: Qiang Xu, Yanshu Wang, Alain Dabdoub, Philip M Smallwood, John Williams, Chad Woods, Matthew W Kelley, Li Jiang, William Tasman, Kang Zhang,…

  Source: Cell. 2004 Mar 19

  View Full Text

• Genetic ablation of cone photoreceptors eliminates retinal folds in the retinal degeneration 7 (rd7) mouse.

  PURPOSE: Folds or pseudorosettes in the outer retina are commonly observed in animals with genetic, viral, or chemically induced retinal degeneration.…

  Authors: Jichao Chen, Jeremy Nathans

  Source: Investigative ophthalmology & visual science. 2007 Jun

  View Full Text

• An evolutionary perspective on the photoreceptor damage response.

  PURPOSE: To review recent advances related to the response to photoreceptor damage and to place this knowledge in an evolutionary context. DESIGN: Syn…

  Authors: Amir Rattner, Jeremy Nathans

  Source: American journal of ophthalmology. 2006 Mar

  View Full Text

• The evolution of Primate color vision.

  Authors: Gerald H Jacobs, Jeremy Nathans

  Source: Scientific American. 2009 Apr

  View Full Text

• An essential role for frizzled 5 in mammalian ocular development.

  Microphthalmia, coloboma and persistent fetal vasculature within the vitreous cavity are among the most common human congenital ocular anomalies, and …

  Authors: Chunqiao Liu, Jeremy Nathans

  Source: Development (Cambridge, England). 2008 Nov

  View Full Text

• The optokinetic reflex as a tool for quantitative analyses of nervous system function in mice: application to genetic and drug-induced variation.

  The optokinetic reflex (OKR), which serves to stabilize a moving image on the retina, is a behavioral response that has many favorable attributes as a…

  Authors: Hugh Cahill, Jeremy Nathans

  Source: PloS one. 2008

  View Full Text