1 to 10 of 97 literature results

• TMPRSS2-ERG and PTEN loss in prostate cancer.

  Two studies show that the common recurrent gene fusion between TMPRSS2 and ERG promotes prostate cancer in both mouse and humans when PTEN is concurre…

  Authors: Jeremy A Squire

  Source: Nature genetics. 2009 May

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• Identification of human brain tumour initiating cells.

  The cancer stem cell (CSC) hypothesis suggests that neoplastic clones are maintained exclusively by a rare fraction of cells with stem cell properties…

  Authors: Sheila K Singh, Cynthia Hawkins, Ian D Clarke, Jeremy A Squire, Jane Bayani, Takuichiro Hide, R Mark Henkelman, Michael D Cusimano, Peter B Dirks

  Source: Nature. 2004 Nov 18

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• Identification of interactive networks of gene expression associated with osteosarcoma oncogenesis by integrated molecular profiling.

  Altered gene expression in tumors can be caused by copy number alterations to DNA or mutation affecting coding or regulatory regions of genes. However…

  Authors: Bekim Sadikovic, Maisa Yoshimoto, Susan Chilton-MacNeill, Paul Thorner, Jeremy A Squire, Maria Zielenska

  Source: Human molecular genetics. 2009 Jun 1

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• The interval between Ins2 and Ascl2 is dispensable for imprinting centre function in the murine Beckwith-Wiedemann region.

  Imprinted genes are commonly clustered in domains across the mammalian genome, suggesting a degree of coregulation via long-range coordination of thei…

  Authors: Louis Lefebvre, Lynn Mar, Aaron Bogutz, Rosemary Oh-McGinnis, Mohammad Mandegar, Jana Paderova, Marina Gertsenstein, Jeremy A Squire, Andras Nagy

  Source: Human molecular genetics. 2009 Aug 14

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• Reduced tumorigenesis in p53 knockout mice exposed in utero to low-dose vitamin E.

  BACKGROUND: The limited antioxidative capacity of the fetus renders it more susceptible to reactive oxygen species (ROS), and possibly to ROS-mediated…

  Authors: Connie S Chen, Jeremy A Squire, Peter G Wells

  Source: Cancer. 2009 Apr 1

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• Loss of RB1 induces non-proliferative retinoma: increasing genomic instability correlates with progression to retinoblastoma.

  Retinoblastoma clinical observations revealed the role of tumor suppressor genes in human cancer, Knudson's 'two-hit' model of cancer induction. We no…

  Authors: Helen Dimaras, Vikas Khetan, William Halliday, Marija Orlic, Nadia L Prigoda, Beata Piovesan, Paula Marrano, Timothy W Corson, Ralph C Eagle, Jeremy A Squire,…

  Source: Human molecular genetics. 2008 May 15

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• Epigenetic and phenotypic consequences of a truncation disrupting the imprinted domain on distal mouse chromosome 7.

  The distal end of mouse chromosome 7 (Chr 7) contains a large cluster of imprinted genes. In this region two cis-acting imprinting centers, IC1 (H19 D…

  Authors: Rosemary Oh, Rita Ho, Lynn Mar, Marina Gertsenstein, Jana Paderova, John Hsien, Jeremy A Squire, Michael J Higgins, Andras Nagy, Louis Lefebvre

  Source: Molecular and cellular biology. 2008 Feb

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• ASAP1, a gene at 8q24, is associated with prostate cancer metastasis.

  Metastatic prostate cancer is a terminal disease, and the development of reliable prognostic tools and more effective therapy is critically important …

  Authors: Dong Lin, Akira Watahiki, Jane Bayani, Fang Zhang, Lin Liu, Victor Ling, Marianne D Sadar, John English, Ladan Fazli, Alan So,…

  Source: Cancer research. 2008 Jun 1

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• Stem cell enrichment approaches.

  Adult somatic tissue, and the tumours that arise therein, are maintained by a small population of stem cells. In addition to the self-renewal potentia…

  Authors: Paul C Park, Shamini Selvarajah, Jane Bayani, Maria Zielenska, Jeremy A Squire

  Source: Seminars in cancer biology. 2007 Jun

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• The RAG-1/2 endonuclease causes genomic instability and controls CNS complications of lymphoblastic leukemia in p53/Prkdc-deficient mice.

  Double-strand DNA breaks (DSB) induce chromosomal translocations and gene amplification in cell culture, but mechanisms by which DSB cause genomic ins…

  Authors: Rebecca A Gladdy, Michael D Taylor, Christine J Williams, Ildiko Grandal, Jana Karaskova, Jeremy A Squire, James T Rutka, Cynthia J Guidos, Jayne S Danska

  Source: Cancer cell. 2003 Jan

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