1 to 10 of 12 literature results

• ETS rearrangements and prostate cancer initiation.

  The first recurrent translocation event in prostate cancer has been recently described; it results in the translocation of an ETS (E26 transformation …

  Authors: Brett S Carver, Jennifer Tran, Zhenbang Chen, Arkaitz Carracedo-Perez, Andrea Alimonti, Caterina Nardella, Anuradha Gopalan, Peter T Scardino, Carlos Cordon-Cardo, William Gerald,…

  Source: Nature. 2009 Feb 12

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• Aberrant ERG expression cooperates with loss of PTEN to promote cancer progression in the prostate.

  Chromosomal translocations involving the ERG locus are frequent events in human prostate cancer pathogenesis; however, the biological role of aberrant…

  Authors: Brett S Carver, Jennifer Tran, Anuradha Gopalan, Zhenbang Chen, Safa Shaikh, Arkaitz Carracedo, Andrea Alimonti, Caterina Nardella, Shohreh Varmeh, Peter T Scardino,…

  Source: Nature genetics. 2009 May

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• A unique autophosphorylation site on Tie2/Tek mediates Dok-R phosphotyrosine binding domain binding and function.

  Tie2/Tek is an endothelial cell receptor tyrosine kinase that induces signal transduction pathways involved in cell migration upon angiopoietin-1 (Ang…

  Authors: Nina Jones, Stephen H Chen, Celina Sturk, Zubin Master, Jennifer Tran, Robert S Kerbel, Daniel J Dumont

  Source: Molecular and cellular biology. 2003 Apr

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• Design at the atomic level: design of biaryloxazolidinones as potent orally active antibiotics.

  We have developed a first generation of hybrid sparsomycin-linezolid compounds into a new family of orally bioavailable biaryloxazolidinones that have…

  Authors: Jiacheng Zhou, Ashoke Bhattacharjee, Shili Chen, Yi Chen, Erin Duffy, Jay Farmer, Joel Goldberg, Roger Hanselmann, Joseph A Ippolito, Rongliang Lou,…

  Source: Bioorganic & medicinal chemistry letters. 2008 Dec 1

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• Design at the atomic level: generation of novel hybrid biaryloxazolidinones as promising new antibiotics.

  From the X-ray crystal structures of linezolid and the non-selective antibiotic sparsomycin, we have derived a new family of hybrid oxazolidinones. Fr…

  Authors: Jiacheng Zhou, Ashoke Bhattacharjee, Shili Chen, Yi Chen, Erin Duffy, Jay Farmer, Joel Goldberg, Roger Hanselmann, Joseph A Ippolito, Rongliang Lou,…

  Source: Bioorganic & medicinal chemistry letters. 2008 Dec 1

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• Wound care for persons with diabetes.

  This article addresses local wound care in people with diabetes mellitus. An approach is proposed that uses wound depth and color to determine the goa…

  Authors: Evonne M Fowler, Noreen Vesely, Vivian Johnson, Judy Harwood, Jennifer Tran, Thomas Amberry

  Source: Home healthcare nurse. 2003 Aug

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• A cyclosporine-sensitive psoriasis-like disease produced in Tie2 transgenic mice.

  Psoriasis is a common, persistent skin disorder characterized by recurrent erythematous lesions thought to arise as a result of inflammatory cell infi…

  Authors: Daniel Voskas, Nina Jones, Paul Van Slyke, Celina Sturk, Wing Chang, Alex Haninec, Yael Olya Babichev, Jennifer Tran, Zubin Master, Stephen Chen,…

  Source: The American journal of pathology. 2005 Mar

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• Dok-R binds c-Abl and regulates Abl kinase activity and mediates cytoskeletal reorganization.

  Dok-R, also known as Dok-2/FRIP, belongs to the DOK family of signaling molecules that become tyrosine-phosphorylated by several different receptor an…

  Authors: Zubin Master, Jennifer Tran, Aseem Bishnoi, Stephen H Chen, John M L Ebos, Paul Van Slyke, Robert S Kerbel, Daniel J Dumont

  Source: The Journal of biological chemistry. 2003 Aug 8

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• A role for survivin in chemoresistance of endothelial cells mediated by VEGF.

  Although standard anticancer chemotherapeutic drugs have been designed to inhibit the survival or growth of rapidly dividing tumor cells, it is possib…

  Authors: Jennifer Tran, Zubin Master, Joanne L Yu, Janusz Rak, Daniel J Dumont, Robert S Kerbel

  Source: Proceedings of the National Academy of Sciences of the United States of America. 2002 Apr 2

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• Imatinib mesylate (STI-571) reduces Bcr-Abl-mediated vascular endothelial growth factor secretion in chronic myelogenous leukemia.

  A large and diverse spectrum of oncogenes has been implicated as a contributor to angiogenesis in solid tumors based, in part, on its ability to induc…

  Authors: John M L Ebos, Jennifer Tran, Zubin Master, Daniel Dumont, Junia V Melo, Elisabeth Buchdunger, Robert S Kerbel

  Source: Molecular cancer research : MCR. 2002 Dec

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