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1 to 10 of 23 literature results
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Phosphoinositide signalling links O-GlcNAc transferase to insulin resistance.
Glucose flux through the hexosamine biosynthetic pathway leads to the post-translational modification of cytoplasmic and nuclear proteins by O-linked …
Authors: Xiaoyong Yang, Pat P Ongusaha, Philip D Miles, Joyce C Havstad, Fengxue Zhang, W Venus So, Jeffrey E Kudlow, Robert H Michell, Jerrold M Olefsky, Seth J Field,…
Source: Nature. 2008 Feb 21
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Recruitment of O-GlcNAc transferase to promoters by corepressor mSin3A: coupling protein O-GlcNAcylation to transcriptional repression.
Transcription factors and RNA polymerase II can be modified by O-linked N-acetylglucosamine (O-GlcNAc) monosaccharides at serine or threonine residues…
Authors: Xiaoyong Yang, Fengxue Zhang, Jeffrey E Kudlow
Source: Cell. 2002 Jul 12
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O-GlcNAc modification is an endogenous inhibitor of the proteasome.
The ubiquitin proteasome system classically selects its substrates for degradation by tagging them with ubiquitin. Here, we describe another means of …
Authors: Fengxue Zhang, Kaihong Su, Xiaoyong Yang, Damon B Bowe, Andrew J Paterson, Jeffrey E Kudlow
Source: Cell. 2003 Dec 12
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Post-translational modification by O-GlcNAc: another way to change protein function.
Modification of intracellular proteins by the beta-linkage of the monosaccharide, N-acetylglucosamine to serine or threonine hydroxyls (O-GlcNAc) is a…
Authors: Jeffrey E Kudlow
Source: Journal of cellular biochemistry. 2006 Aug 1
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O-GlcNAcylation enhances FOXO4 transcriptional regulation in response to stress.
The FOXO4 transcription factor plays an important role in cell survival in response to oxidative stress. The regulation of FOXO4 is orchestrated by po…
Authors: Shiuh-Rong Ho, Kai Wang, Thomas R Whisenhunt, Ping Huang, Xiaolin Zhu, Jeffrey E Kudlow, Andrew J Paterson
Source: FEBS letters. 2010 Jan 4
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O-GlcNAc integrates the proteasome and transcriptome to regulate nuclear hormone receptors.
Mechanisms controlling nuclear hormone receptors are a central question to mammalian developmental and disease processes. Herein, we show that a subtl…
Authors: Damon B Bowe, Andrea Sadlonova, Clifford A Toleman, Zdenek Novak, Yong Hu, Ping Huang, Shibani Mukherjee, Timothy Whitsett, Andra R Frost, Andrew J Paterson,…
Source: Molecular and cellular biology. 2006 Nov
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Streptozotocin inhibits O-GlcNAcase via the production of a transition state analog.
Streptozotocin (STZ) is a 2-deoxy-d-glucopyranose derivative of a class of drugs known as alkylnitrosoureas, and is an established diabetogenic agent …
Authors: Clifford Toleman, Andrew J Paterson, Ronald Shin, Jeffrey E Kudlow
Source: Biochemical and biophysical research communications. 2006 Feb 10
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Disrupting the enzyme complex regulating O-GlcNAcylation blocks signaling and development.
Although the knowledge that nuclear and cytoplasmic proteins are modified with N-acetylglucosamine has existed for decades, little has been shown as t…
Authors: Thomas R Whisenhunt, Xiaoyong Yang, Damon B Bowe, Andrew J Paterson, Brian A Van Tine, Jeffrey E Kudlow
Source: Glycobiology. 2006 Jun
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Increased O-GlcNAc causes disrupted lens fiber cell differentiation and cataracts.
Diminished proteolytic functionality in the lens may cause cataracts. We have reported that O-GlcNAc is an endogenous inhibitor of the proteasome. We …
Authors: Kai Wang, Shiuh-Rong Ho, Weiming Mao, Ping Huang, Fengxue Zhang, Erik M Schwiebert, Jeffrey E Kudlow, Andrew J Paterson
Source: Biochemical and biophysical research communications. 2009 Sep 11
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Induction of KLF4 in basal keratinocytes blocks the proliferation-differentiation switch and initiates squamous epithelial dysplasia.
KLF4/GKLF normally functions in differentiating epithelial cells, but also acts as a transforming oncogene in vitro. To examine the role of this zinc …
Authors: K Wade Foster, Zhaoli Liu, Clinton D Nail, Xingnan Li, Thomas J Fitzgerald, Sarah K Bailey, Andra R Frost, Iuri D Louro, Tim M Townes, Andrew J Paterson,…
Source: Oncogene. 2005 Feb 24
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