1 to 10 of 25 literature results

• Further evidence for BRCA1 communication with the inactive X chromosome.

  BRCA1, a breast and ovarian cancer-suppressor gene, exerts tumor-suppressing functions that appear to be associated, at least in part, with its DNA re…

  Authors: Daniel P Silver, Stoil D Dimitrov, Jean Feunteun, Rebecca Gelman, Ronny Drapkin, Shihua D Lu, Elena Shestakova, Soundarapandian Velmurugan, Nicholas Denunzio, Serban Dragomir,…

  Source: Cell. 2007 Mar 9

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• High frequency of TP53 mutation in BRCA1 and sporadic basal-like carcinomas but not in BRCA1 luminal breast tumors.

  Breast tumors with a germ-line mutation of BRCA1 (BRCA1 tumors) and basal-like carcinoma (BLC) are associated with a high rate of TP53 mutation. Becau…

  Authors: Elodie Manié, Anne Vincent-Salomon, Jacqueline Lehmann-Che, Gaelle Pierron, Elisabeth Turpin, Mathilde Warcoin, Nadège Gruel, Ingrid Lebigot, Xavier Sastre-Garau, Rosette Lidereau,…

  Source: Cancer research. 2009 Jan 15

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• BRCA1 supports XIST RNA concentration on the inactive X chromosome.

  BRCA1, a breast and ovarian tumor suppressor, colocalizes with markers of the inactive X chromosome (Xi) on Xi in female somatic cells and associates …

  Authors: Shridar Ganesan, Daniel P Silver, Roger A Greenberg, Dror Avni, Ronny Drapkin, Alexander Miron, Samuel C Mok, Voahangy Randrianarison, Steven Brodie, Jennifer Salstrom,…

  Source: Cell. 2002 Nov 1

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• Thirteenth annual pezcoller symposium: focusing analytical tools on complexity in cancer.

  The physiopathology of cancer cells is the result of very complex signaling networks that represent in many cases distortions of the orderly networks …

  Authors: Enrico Mihich, Jean Feunteun, Stephen Friend

  Source: Cancer research. 2002 Jul 1

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• PML nuclear bodies are highly organised DNA-protein structures with a function in heterochromatin remodelling at the G2 phase.

  We have recently demonstrated that heterochromatin HP1 proteins are aberrantly distributed in lymphocytes of patients with immunodeficiency, centromer…

  Authors: Judith J Luciani, Danielle Depetris, Yves Usson, Catherine Metzler-Guillemain, Cecile Mignon-Ravix, Micheal J Mitchell, Andre Megarbane, Pierre Sarda, Huseyin Sirma, Anne Moncla,…

  Source: Journal of cell science. 2006 Jun 15

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• Megakaryocyte polyploidization is associated with a functional gene amplification.

  It is believed that polyploidy induces an orchestrated increase in gene expression. To know whether all alleles remain functional during megakaryocyte…

  Authors: Hana Raslova, Lydia Roy, Claire Vourc'h, Jean Pierre Le Couedic, Olivier Brison, Didier Metivier, Jean Feunteun, Guido Kroemer, Najet Debili, William Vainchenker

  Source: Blood. 2003 Jan 15

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• Down-regulation of BRCA1 in BCR-ABL-expressing hematopoietic cells.

  BCR-ABL fusion oncogene is the molecular hallmark of chronic myelogenous leukemia (CML), a condition characterized by a progression from a chronic to …

  Authors: Eric Deutsch, Sylvie Jarrousse, Dorothee Buet, Aymeric Dugray, Marie-Laure Bonnet, Marie-Catherine Vozenin-Brotons, Francois Guilhot, Ali G Turhan, Jean Feunteun, Jean Bourhis

  Source: Blood. 2003 Jun 1

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• Loss of FADD protein expression results in a biased Fas-signaling pathway and correlates with the development of tumoral status in thyroid follicular cells.

  Downregulation of proapoptotic molecules like Fas or caspase 8, or upregulation of antiapoptotic molecules like FLICE inhibitory protein has been sugg…

  Authors: Léa Tourneur, Sylvie Mistou, Francine-Marie Michiels, Valérie Devauchelle, Laurent Renia, Jean Feunteun, Gilles Chiocchia

  Source: Oncogene. 2003 May 8

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• Mitotic catastrophe constitutes a special case of apoptosis whose suppression entails aneuploidy.

  A conflict in cell cycle progression or DNA damage can lead to mitotic catastrophe when the DNA structure checkpoints are inactivated, for instance wh…

  Authors: Maria Castedo, Jean-Luc Perfettini, Thomas Roumier, Alexander Valent, Hana Raslova, Kenichi Yakushijin, David Horne, Jean Feunteun, Gilbert Lenoir, René Medema,…

  Source: Oncogene. 2004 May 27

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• Screening for TP53 rearrangements in families with the Li-Fraumeni syndrome reveals a complete deletion of the TP53 gene.

  The absence of detectable germline TP53 mutations in a fraction of families with Li-Fraumeni syndrome (LFS) has suggested the involvement of other gen…

  Authors: Gaëlle Bougeard, Laurence Brugières, Agnès Chompret, Paul Gesta, Françoise Charbonnier, Alexander Valent, Cosette Martin, Grégory Raux, Jean Feunteun, Brigitte Bressac-de Paillerets,…

  Source: Oncogene. 2003 Feb 13

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