1 to 10 of 26 literature results

• Rb loss causes cancer by driving mitosis mad.

  Aneuploidy is a hallmark of most human cancers, but whether it is a cause or a consequence of cellular transformation remains a subject of debate. The…

  Authors: Jan M van Deursen

  Source: Cancer cell. 2007 Jan

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• Whole chromosome instability caused by Bub1 insufficiency drives tumorigenesis through tumor suppressor gene loss of heterozygosity.

  Genetic alterations that promote chromosome missegregation have been proposed to drive tumorigenesis through loss of whole chromosomes containing key …

  Authors: Darren J Baker, Fang Jin, Karthik B Jeganathan, Jan M van Deursen

  Source: Cancer cell. 2009 Dec 8

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• The Rae1-Nup98 complex prevents aneuploidy by inhibiting securin degradation.

  Cdc20 and Cdh1 are the activating subunits of the anaphase-promoting complex (APC), an E3 ubiquitin ligase that drives cells into anaphase by inducing…

  Authors: Karthik B Jeganathan, Liviu Malureanu, Jan M van Deursen

  Source: Nature. 2005 Dec 15

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• Resolution of sister centromeres requires RanBP2-mediated SUMOylation of topoisomerase IIalpha.

  RanBP2 is a nucleoporin with SUMO E3 ligase activity that functions in both nucleocytoplasmic transport and mitosis. However, the biological relevance…

  Authors: Meelad M Dawlaty, Liviu Malureanu, Karthik B Jeganathan, Esther Kao, Claudio Sustmann, Samuel Tahk, Ke Shuai, Rudolf Grosschedl, Jan M van Deursen

  Source: Cell. 2008 Apr 4

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• BubR1 N terminus acts as a soluble inhibitor of cyclin B degradation by APC/C(Cdc20) in interphase.

  BubR1 is an essential mitotic checkpoint protein with multiple functional domains. It has been implicated in mitotic checkpoint control, as an active …

  Authors: Liviu A Malureanu, Karthik B Jeganathan, Masakazu Hamada, Lisa Wasilewski, James Davenport, Jan M van Deursen

  Source: Developmental cell. 2009 Jan

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• Plk1-dependent phosphorylation of FoxM1 regulates a transcriptional programme required for mitotic progression.

  Proper control of entry into and progression through mitosis is essential for normal cell proliferation and the maintenance of genome stability. The m…

  Authors: Zheng Fu, Liviu Malureanu, Jun Huang, Wei Wang, Hao Li, Jan M van Deursen, Donald J Tindall, Junjie Chen

  Source: Nature cell biology. 2008 Sep

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• Plk1-dependent phosphorylation of FoxM1 regulates a transcriptional programme required for mitotic progression.

  Proper control of entry into and progression through mitosis is essential for normal cell proliferation and the maintenance of genome stability. The m…

  Authors: Zheng Fu, Liviu Malureanu, Jun Huang, Wei Wang, Hao Li, Jan M van Deursen, Donald J Tindall, Junjie Chen

  Source: Nature cell biology. 2008 Aug 10

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• Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency.

  Expression of p16(Ink4a) and p19(Arf) increases with age in both rodent and human tissues. However, whether these tumour suppressors are effectors of …

  Authors: Darren J Baker, Carmen Perez-Terzic, Fang Jin, Kevin Pitel, Nicolas J Niederländer, Karthik Jeganathan, Satsuki Yamada, Santiago Reyes, Lois Rowe, H Jay Hiddinga,…

  Source: Nature cell biology. 2008 Jul

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• Induction of prostatic intraepithelial neoplasia and modulation of androgen receptor by ETS variant 1/ETS-related protein 81.

  ETS variant 1 (ETV1), also known as ETS-related protein 81, is overexpressed in prostate tumors, but whether and how this transcription factor affects…

  Authors: Sook Shin, Tae-Dong Kim, Fang Jin, Jan M van Deursen, Scott M Dehm, Donald J Tindall, Joseph P Grande, Jan-Marie Munz, George Vasmatzis, Ralf Janknecht

  Source: Cancer research. 2009 Oct 15

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• BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice.

  Faithful segregation of replicated chromosomes is essential for maintenance of genetic stability and seems to be monitored by several mitotic checkpoi…

  Authors: Darren J Baker, Karthik B Jeganathan, J Douglas Cameron, Michael Thompson, Subhash Juneja, Alena Kopecka, Rajiv Kumar, Robert B Jenkins, Piet C de Groen, Patrick Roche,…

  Source: Nature genetics. 2004 Jul

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