1 to 8 of 8 literature results

• Evolutionarily conserved amino acids that control TCR-MHC interaction.

  The rules for the conserved reaction of alphabeta T cell receptors (TCRs) with major histocompatibility complex (MHC) proteins plus peptides are poorl…

  Authors: Philippa Marrack, James P Scott-Browne, Shaodong Dai, Laurent Gapin, John W Kappler

  Source: Annual review of immunology. 2008

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• Germline-encoded amino acids in the alphabeta T-cell receptor control thymic selection.

  An alphabeta T-cell response depends on the recognition of antigen plus major histocompatibility complex (MHC) proteins by its antigen receptor (TCR).…

  Authors: James P Scott-Browne, Janice White, John W Kappler, Laurent Gapin, Philippa Marrack

  Source: Nature. 2009 Apr 23

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• Germline-encoded recognition of diverse glycolipids by natural killer T cells.

  Natural killer T cells expressing 'invariant' T cell receptor alpha-chains (TCRalpha chains) containing variable (V) and joining (J) region V(alpha)14…

  Authors: James P Scott-Browne, Jennifer L Matsuda, Thierry Mallevaey, Janice White, Natalie A Borg, James McCluskey, Jamie Rossjohn, John Kappler, Philippa Marrack, Laurent Gapin

  Source: Nature immunology. 2007 Oct

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• T cell receptor CDR2 beta and CDR3 beta loops collaborate functionally to shape the iNKT cell repertoire.

  Mouse type I natural killer T cell receptors (iNKT TCRs) use a single V alpha 14-J alpha 18 sequence and V beta s that are almost always V beta 8.2, V…

  Authors: Thierry Mallevaey, James P Scott-Browne, Jennifer L Matsuda, Mary H Young, Daniel G Pellicci, Onisha Patel, Meena Thakur, Lars Kjer-Nielsen, Stewart K Richardson, Vincenzo Cerundolo,…

  Source: Immunity. 2009 Jul 17

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• A knock-in mouse model of gastrointestinal stromal tumor harboring kit K641E.

  A mouse model of gastrointestinal stromal tumor (GIST) has been developed by a knock-in gene targeting strategy, which introduced a Kit gene K641E mut…

  Authors: Brian P Rubin, Cristina R Antonescu, James P Scott-Browne, Melissa L Comstock, Yansong Gu, Munir R Tanas, Carol B Ware, Jessica Woodell

  Source: Cancer research. 2005 Aug 1

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• Many different Vbeta CDR3s can reveal the inherent MHC reactivity of germline-encoded TCR V regions.

  We have hypothesized that in the prenegative selection TCR repertoire, many somatically generated complementary-determining region (CDR) 3 loops combi…

  Authors: Kira Rubtsova, James P Scott-Browne, Frances Crawford, Shaodong Dai, Philippa Marrack, John W Kappler

  Source: Proceedings of the National Academy of Sciences of the United States of America. 2009 May 12

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• A minimal binding footprint on CD1d-glycolipid is a basis for selection of the unique human NKT TCR.

  Although it has been established how CD1 binds a variety of lipid antigens (Ag), data are only now emerging that show how alphabeta T cell receptors (…

  Authors: Kwok S Wun, Natalie A Borg, Lars Kjer-Nielsen, Travis Beddoe, Ruide Koh, Stewart K Richardson, Meena Thakur, Amy R Howell, James P Scott-Browne, Laurent Gapin,…

  Source: The Journal of experimental medicine. 2008 Apr 14

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• Expansion and function of Foxp3-expressing T regulatory cells during tuberculosis.

  Mycobacterium tuberculosis (Mtb) frequently establishes persistent infections that may be facilitated by mechanisms that dampen immunity. T regulatory…

  Authors: James P Scott-Browne, Shahin Shafiani, Glady's Tucker-Heard, Kumiko Ishida-Tsubota, Jason D Fontenot, Alexander Y Rudensky, Michael J Bevan, Kevin B Urdahl

  Source: The Journal of experimental medicine. 2007 Sep 3

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